ENSGALG00000000843


Gallus gallus

Features
Gene ID: ENSGALG00000000843
  
Biological name :DOT1L
  
Synonyms : DOT1L / DOT1 like histone lysine methyltransferase
  
Possible biological names infered from orthology : Q8TEK3
  
Species: Gallus gallus
  
Chr. number: 28
Strand: -1
Band:
Gene start: 2041020
Gene end: 2096657
  
Corresponding Affymetrix probe sets: Gga.2178.1.S1_at (Chicken Array)   Gga.2178.2.S1_at (Chicken Array)   Gga.2178.2.S1_a_at (Chicken Array)   Gga.6999.1.S1_at (Chicken Array)   GgaAffx.22303.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000001234
Ensembl peptide - ENSGALP00000054453
Ensembl peptide - ENSGALP00000047355
Ensembl peptide - ENSGALP00000046875
NCBI entrez gene - 420078     See in Manteia.
RefSeq - XM_015299869
RefSeq - XM_015299864
RefSeq - XM_015299865
RefSeq - XM_015299866
RefSeq - XM_015299868
swissprot - A0A1D5P3V0
swissprot - A0A1D5P2I0
swissprot - F1NDF2
swissprot - A0A1D5PNL0
Ensembl - ENSGALG00000000843
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dot1lENSDARG00000061992Danio rerio
 DOT1LENSG00000104885Homo sapiens
 Dot1lENSMUSG00000061589Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR021169  Histone H3-K79 methyltransferase, metazoa
 IPR025789  Histone-lysine N-methyltransferase DOT1 domain
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR030445  Histone H3-K79 methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IBA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006342 chromatin silencing IEA
 biological_processGO:0006348 chromatin silencing at telomere IBA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034729 histone H3-K79 methylation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046425 regulation of JAK-STAT cascade IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:2000677 regulation of transcription regulatory region DNA binding IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0031151 histone methyltransferase activity (H3-K79 specific) IEA
 molecular_functionGO:0042054 histone methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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