ENSGALG00000001764


Gallus gallus

Features
Gene ID: ENSGALG00000001764
  
Biological name :HCN4
  
Synonyms : HCN4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4
  
Possible biological names infered from orthology : Q9Y3Q4
  
Species: Gallus gallus
  
Chr. number: 10
Strand: -1
Band:
Gene start: 1953570
Gene end: 2049857
  
Corresponding Affymetrix probe sets: GgaAffx.1155.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002705
NCBI entrez gene - 427478     See in Manteia.
RefSeq - XM_425050
swissprot - F1NGZ9
Ensembl - ENSGALG00000001764
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01086574.1ENSDARG00000116404Danio rerio
 hcn4ENSDARG00000061685Danio rerio
 hcn4lENSDARG00000074419Danio rerio
 HCN4ENSG00000138622Homo sapiens
 Hcn4ENSMUSG00000032338Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HCN2 / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 / O88703* / Q9UL51* / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 *ENSGALG0000000134247
HCN1 / hyperpolarization activated cyclic nucleotide gated potassium channel 1 / O60741* / O88704* / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 *ENSGALG0000001487547
HCN3 / hyperpolarization activated cyclic nucleotide gated potassium channel 3 / O88705* / Q9P1Z3* / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 *ENSGALG0000003365346
CNGA1 / Q90980 / Cyclic nucleotide-gated channel rod photoreceptor subunit alpha / P29973* / P29974* / cGMP-gated cation channel alpha-1 * / cyclic nucleotide gated channel alpha 1*ENSGALG0000001413613
CNGA3 / cyclic nucleotide-gated channel cone photoreceptor subunit alpha / Q16281* / Q9JJZ8* / cyclic nucleotide gated channel alpha 3* / Cyclic nucleotide-gated cation channel alpha-3 *ENSGALG0000003982613
CNGB1 / cyclic nucleotide gated channel beta 1 / Q14028*ENSGALG0000004264712
CNGA2 / cyclic nucleotide gated channel alpha 2 / Q16280* / Q62398* / Cyclic nucleotide-gated olfactory channel *ENSGALG0000000728210
CNGB3 / cyclic nucleotide gated channel beta 3 / Q9JJZ9* / Q9NQW8* / Cyclic nucleotide-gated cation channel beta-3 *ENSGALG0000003764410
CNGA4 / cyclic nucleotide gated channel alpha 4 / Q3UW12* / Q8IV77* / Cyclic nucleotide-gated cation channel alpha-4 *ENSGALG000000227048


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR005821  Ion transport domain
 IPR013621  Ion transport N-terminal
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR030173  Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0003254 regulation of membrane depolarization IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071321 cellular response to cGMP IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0086015 SA node cell action potential IEA
 biological_processGO:0086046 membrane depolarization during SA node cell action potential IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IEA
 biological_processGO:0098719 sodium ion import across plasma membrane IEA
 biological_processGO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction IEA
 biological_processGO:1990573 potassium ion import across plasma membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0098855 HCN channel complex IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005222 intracellular cAMP activated cation channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0086041 voltage-gated potassium channel activity involved in SA node cell action potential depolarization IEA


Pathways (from Reactome)
Pathway description
HCN channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001764 HCN4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4 / Q9Y3Q4*  / complex






 

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