ENSGALG00000002203


Gallus gallus

Features
Gene ID: ENSGALG00000002203
  
Biological name :FGF18
  
Synonyms : FGF18 / fibroblast growth factor 18
  
Possible biological names infered from orthology : O76093 / O89101
  
Species: Gallus gallus
  
Chr. number: 13
Strand: -1
Band:
Gene start: 3197465
Gene end: 3262685
  
Corresponding Affymetrix probe sets: Gga.245.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000003444
Ensembl peptide - ENSGALP00000054695
NCBI entrez gene - 395453     See in Manteia.
RefSeq - XM_015293588
RefSeq - NM_204714
RefSeq Peptide - NP_990045
swissprot - Q9I950
swissprot - F6RRS5
Ensembl - ENSGALG00000002203
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf18aENSDARG00000088048Danio rerio
 fgf18bENSDARG00000043962Danio rerio
 FGF18ENSG00000156427Homo sapiens
 Fgf18ENSMUSG00000057967Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF8 / fibroblast growth factor 8 precursor / P37237* / P55075* / fibroblast growth factor 8*ENSGALG0000000770646


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028289  Fibroblast growth factor 18


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001957 intramembranous ossification IEA
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0002063 chondrocyte development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005730 nucleolus IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005105 type 1 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005111 type 2 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR2c ligand binding and activation
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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