ENSGALG00000002301


Gallus gallus
regulationCNOT1complexccr-notmrnadomaintranscriptionbindingsubunitreceptornuclear-transcribedcatabolicprocesspathwayrepeatrnadeadenylation-dependentdecayestrogensignalingretinoicacidpolycellactivitycomponentc-terminalunknownfunctionduf

Features
Gene ID: ENSGALG00000002301
  
Biological name :CNOT1
  
Synonyms : CCR4-NOT transcription complex subunit 1 / CNOT1
  
Possible biological names infered from orthology : A5YKK6 / Q6ZQ08
  
Species: Gallus gallus
  
Chr. number: 11
Strand: -1
Band:
Gene start: 1472262
Gene end: 1525501
  
Corresponding Affymetrix probe sets: Gga.10535.1.S1_s_at (Chicken Array)   Gga.10535.2.S1_a_at (Chicken Array)   Gga.10535.2.S1_s_at (Chicken Array)   Gga.3127.1.S1_at (Chicken Array)   GgaAffx.25443.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000003612
NCBI entrez gene - 100858397     See in Manteia.
RefSeq - XM_015279115
RefSeq - NM_001277133
RefSeq - XM_015279113
RefSeq - XM_015279114
RefSeq - XM_015279106
RefSeq - XM_015279107
RefSeq - XM_015279109
RefSeq - XM_015279110
RefSeq - XM_015279111
RefSeq - XM_015279112
RefSeq Peptide - NP_001264062
swissprot - E1C1B8
Ensembl - ENSGALG00000002301
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot1ENSDARG00000004174Danio rerio
 CNOT1ENSG00000125107Homo sapiens
 Cnot1ENSMUSG00000036550Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007196  CCR4-Not complex component, Not1, C-terminal
 IPR024557  CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819
 IPR032191  CCR4-NOT transcription complex subunit 1, CAF1-binding domain
 IPR032193  CCR4-NOT transcription complex subunit 1, TTP binding domain
 IPR032194  CCR4-NOT transcription complex subunit 1, HEAT repeat


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular component organizationcellular component biogenesiscell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusmaintenance of cell numbernitrogen cnitrogen compound metabolic processbiosynthetbiosynthetic processcellular mcellular metabolic processprimary meprimary metabolic processorganic suorganic substance metabolic processcatabolic catabolic processcellular ccellular component organizationcellular ccellular component biogenesiscell commucell communicationresponse tresponse to endogenous stimulusresponse tresponse to chemicalcellular rcellular response to stimulusmaintenancmaintenance of cell number
hydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activitycatalytic activity, acting on RNAprotein bindinghydrolase activityhydrolase activitycatalytic activity, acting on RNAcatalytic activity, acting on RNAprotein bindingprotein binding
cellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellcellprotein-containing complexprotein-containing complexorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
 biological_processGO:0010606 positive regulation of cytoplasmic mRNA processing body assembly IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0035195 gene silencing by miRNA IEA
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IEA
 biological_processGO:0061014 positive regulation of mRNA catabolic process IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
 biological_processGO:2000036 regulation of stem cell population maintenance IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030014 CCR4-NOT complex IEA
 cellular_componentGO:0030015 CCR4-NOT core complex IBA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA
 molecular_functionGO:0042974 retinoic acid receptor binding IEA
 molecular_functionGO:0070016 armadillo repeat domain binding IEA


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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