ENSGALG00000003580


Gallus gallus

Features
Gene ID: ENSGALG00000003580
  
Biological name :MMP2
  
Synonyms : 72 kDa type IV collagenase / MMP2 / Q90611
  
Possible biological names infered from orthology : 72 kDa type IV collagenase PEX / matrix metallopeptidase 2 / P08253 / P33434
  
Species: Gallus gallus
  
Chr. number: 11
Strand: -1
Band:
Gene start: 3807841
Gene end: 3842546
  
Corresponding Affymetrix probe sets: Gga.3199.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000062521
Ensembl peptide - ENSGALP00000005656
NCBI entrez gene - 386583     See in Manteia.
RefSeq - NM_204420
RefSeq Peptide - NP_989751
swissprot - Q90611
swissprot - A0A1L1RUM6
Ensembl - ENSGALG00000003580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp2ENSDARG00000017676Danio rerio
 MMP2ENSG00000087245Homo sapiens
 Mmp2ENSMUSG00000031740Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP9 / matrix metalloproteinase-9 precursor / P14780* / P41245* / matrix metallopeptidase 9* / Matrix metalloproteinase-9 *ENSGALG0000000699247
MMP28 / matrix metallopeptidase 28 / Q9H239* / matrix metallopeptidase 28 (epilysin)*ENSGALG0000000208122
MMP23B / matrix metallopeptidase 23B / Mmp23* / O75900* / O88676* / Matrix metalloproteinase-23 Matrix metalloproteinase-23, soluble form*ENSGALG0000000139214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000562  Fibronectin type II domain
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR013806  Kringle-like fold
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028708  72kDa type IV collagenase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0001955 blood vessel maturation IEA
 biological_processGO:0001957 intramembranous ossification IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0043408 regulation of MAPK cascade IMP
 biological_processGO:0045089 positive regulation of innate immune response IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0051895 negative regulation of focal adhesion assembly IMP
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0060346 bone trabecula formation IEA
 biological_processGO:0061037 negative regulation of cartilage development IMP
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904932 negative regulation of cartilage condensation IMP
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003554 OPTC / opticin precursor / Q9UBM4* / opticin* / opticin isoform 4 *  / reaction
 ENSGALG00000012755 IGF-I / P18254 / Insulin-like growth factor I / IGF1* / P05017* / P05019* / insulin like growth factor 1*  / reaction
 ENSGALG00000035282 IGF2 / P33717 / Insulin-like growth factor II / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / reaction
 ENSGALG00000037940 IGFBP3 / insulin like growth factor binding protein 3 / P17936* / P47878*  / reaction
 ENSGALG00000019061 MMP1* / MMP8* / Mmp1b* / Mmp1a* / P22894* / P03956* / O70138* / Neutrophil collagenase * / matrix metallopeptidase 1* / matrix metallopeptidase 8* / interstitial collagenase A preproprotein *  / reaction
 ENSGALG00000039080 CD44 / CD44 molecule (Indian blood group) / P16070*  / complex / reaction






 

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