ENSGALG00000004523


Gallus gallus

Features
Gene ID: ENSGALG00000004523
  
Biological name :MFN2
  
Synonyms : MFN2 / mitofusin 2
  
Possible biological names infered from orthology : Mus musculus mitofusin 2 (Mfn2), transcript variant 7, mRNA. / O95140 / Q80U63
  
Species: Gallus gallus
  
Chr. number: 21
Strand: -1
Band:
Gene start: 5503613
Gene end: 5512548
  
Corresponding Affymetrix probe sets: Gga.15218.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000007187
Ensembl peptide - ENSGALP00000060569
Ensembl peptide - ENSGALP00000044867
NCBI entrez gene - 419484     See in Manteia.
RefSeq - XM_015297205
RefSeq - XM_015297206
swissprot - E1BSH7
swissprot - A0A1L1RP47
swissprot - A0A1D5NWX4
Ensembl - ENSGALG00000004523
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mfn2ENSDARG00000079504Danio rerio
 MFN2ENSG00000116688Homo sapiens
 Mfn2ENSMUSG00000029020Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MFN1 / mitofusin-1 / Q811U4* / Q8IWA4*ENSGALG0000004187367


Protein motifs (from Interpro)
Interpro ID Name
 IPR006884  Fzo/mitofusin HR2 domain
 IPR022812  Dynamin superfamily
 IPR027089  Mitofusin-2
 IPR027094  Mitofusin family
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001825 blastocyst formation IEA
 biological_processGO:0006626 protein targeting to mitochondrion IEA
 biological_processGO:0007006 mitochondrial membrane organization IEA
 biological_processGO:0008053 mitochondrial fusion IEA
 biological_processGO:0034497 protein localization to phagophore assembly site IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051646 mitochondrion localization IEA
 biological_processGO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031306 intrinsic component of mitochondrial outer membrane IBA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
Pink/Parkin Mediated Mitophagy
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004523 MFN2 / mitofusin 2 / O95140* / Q80U63* / Mus musculus mitofusin 2 (Mfn2), transcript variant 7, mRNA.*  / complex / reaction






 

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