ENSGALG00000004721


Gallus gallus

Features
Gene ID: ENSGALG00000004721
  
Biological name :
  
Synonyms : ATP-sensitive inward rectifier potassium channel 12 / F1NHE9
  
Possible biological names infered from orthology : B7U540 / KCNJ12 / KCNJ18 / P52187 / potassium voltage-gated channel subfamily J member 12 / potassium voltage-gated channel subfamily J member 18 / Q14500
  
Species: Gallus gallus
  
Chr. number: 14
Strand: -1
Band:
Gene start: 4461703
Gene end: 4462992
  
Corresponding Affymetrix probe sets: GgaAffx.2927.1.A1_at (Chicken Array)   GgaAffx.2927.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000007506
NCBI entrez gene - 427662     See in Manteia.
RefSeq - XM_004945170
RefSeq - XM_015294379
RefSeq - XM_004945169
swissprot - R9PXL9
swissprot - F1NHE9
Ensembl - ENSGALG00000004721
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnj12aENSDARG00000104965Danio rerio
 B7U540ENSG00000260458Homo sapiens
 KCNJ12ENSG00000184185Homo sapiens
 Kcnj12ENSMUSG00000042529Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNJ2 / inward rectifier potassium channel 2 / P35561* / P63252* / potassium voltage-gated channel subfamily J member 2* / potassium inwardly-rectifying channel, subfamily J, member 2*ENSGALG0000000437671
KCNJ4 / potassium voltage-gated channel subfamily J member 4 / P48050*ENSGALG0000001225471
KCNJ5 / potassium voltage-gated channel subfamily J member 5 / P48544* / P48545* / G protein-activated inward rectifier potassium channel 4 *ENSGALG0000000118146
ENSGALG0000000993545
KCNJ6 / potassium voltage-gated channel subfamily J member 6 / P48051* / G protein-activated inward rectifier potassium channel 2 isoform Girk2B *ENSGALG0000001605445
KCNJ3 / G protein-activated inward rectifier potassium channel 1 / P48549* / P63250* / potassium voltage-gated channel subfamily J member 3*ENSGALG0000001253744
KCNJ11 / potassium voltage-gated channel subfamily J member 11 / Q14654* / Q61743* / ATP-sensitive inward rectifier potassium channel 11 *ENSGALG0000002050542
KCNJ8 / ATP-sensitive inward rectifier potassium channel 8 / P97794* / Q15842* / potassium voltage-gated channel subfamily J member 8* / potassium inwardly-rectifying channel, subfamily J, member 8*ENSGALG0000002637341
ENSGALG0000000692238
KCNJ1 / potassium voltage-gated channel subfamily J member 1 / O88335* / P48048* / ATP-sensitive inward rectifier potassium channel 1 *ENSGALG0000000116737
KCNJ15 / potassium voltage-gated channel subfamily J member 15 / O88932* / Q99712* / ATP-sensitive inward rectifier potassium channel 15 *ENSGALG0000001605531


Protein motifs (from Interpro)
Interpro ID Name
 IPR003272  Potassium channel, inwardly rectifying, Kir2.2
 IPR013518  Potassium channel, inwardly rectifying, Kir, cytoplasmic
 IPR013673  Potassium channel, inwardly rectifying, Kir, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR016449  Potassium channel, inwardly rectifying, Kir


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IDA
 biological_processGO:0010107 potassium ion import IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031224 intrinsic component of membrane IDA
 molecular_functionGO:0005242 inward rectifier potassium channel activity IDA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Classical Kir channels
Phase 4 - resting membrane potential
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001334 GNB1 / G protein subunit beta 1 / P62873* / P62874* / guanine nucleotide binding protein (G protein), beta 1*  / complex
 ENSGALG00000004373 KCNJ16 / potassium voltage-gated channel subfamily J member 16 / Q9NPI9* / Q9Z307* / Inward rectifier potassium channel 16 *  / complex
 ENSGALG00000004721 F1NHE9 / ATP-sensitive inward rectifier potassium channel 12 / KCNJ18* / P52187* / Q14500* / B7U540* / KCNJ12* / potassium voltage-gated channel subfamily J member 18* / potassium voltage-...  / complex
 ENSGALG00000013200 GABBR2 / gamma-aminobutyric acid type B receptor subunit 2 / O75899* / Q80T41*  / complex






 

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