ENSGALG00000004932


Gallus gallus
proteinATG7enzymeatgautophagyresponseactivityubiquitin-likecellularregulationprocessactivatingnadbindingmodifier-activatingassemblylipidationstarvationmacroautophagyvirushostthif-typefadfoldp-bindingdomainn-terminalautophagosomemitochondrionc-terminal

Features
Gene ID: ENSGALG00000004932
  
Biological name :ATG7
  
Synonyms : ATG7 / Q5ZKY2 / Ubiquitin-like modifier-activating enzyme ATG7
  
Possible biological names infered from orthology : autophagy related 7 / O95352 / Q9D906
  
Species: Gallus gallus
  
Chr. number: 12
Strand: 1
Band:
Gene start: 4379082
Gene end: 4468625
  
Corresponding Affymetrix probe sets: GgaAffx.12055.1.S1_at (Chicken Array)   GgaAffx.3074.1.S1_at (Chicken Array)   GgaAffx.3074.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000051055
Ensembl peptide - ENSGALP00000035497
NCBI entrez gene - 415961     See in Manteia.
RefSeq - XM_015293054
RefSeq - NM_001030592
RefSeq - XM_015293052
RefSeq - XM_015293053
RefSeq Peptide - NP_001025763
swissprot - A0A1I7Q439
swissprot - Q5ZKY2
Ensembl - ENSGALG00000004932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atg7ENSDARG00000102893Danio rerio
 ATG7ENSG00000197548Homo sapiens
 Atg7ENSMUSG00000030314Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000594  THIF-type NAD/FAD binding fold
 IPR006285  Ubiquitin-like modifier-activating enzyme Atg7
 IPR016040  NAD(P)-binding domain
 IPR032197  Ubiquitin-like modifier-activating enzyme Atg7, N-terminal


Gene Ontology (GO)
catabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationresponse to external stimuluscellular response to stimulusmacromolecule localizationestablishment of localizationinterspecies interaction between organismscell deathresponse to biotic stimulusimmune effector processresponse to chemicalresponse to abiotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationresponse to external stimuluscellular response to stimulusmacromolecule localizationestablishment of localizationinterspecies interaction between organismscell deathresponse to biotic stimulusimmune effector processresponse to chemicalresponse to abiotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationresponse to external stimuluscellular response to stimulusmacromolecule localizationestablishment of localizationinterspecies interaction between organismscell deathresponse to biotic stimulusimmune effector processresponse to chemicalresponse to abiotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationresponse to external stimuluscellular response to stimulusmacromolecule localizationestablishment of localizationinterspecies interaction between organismscell deathresponse to biotic stimulusimmune effector processresponse to chemicalresponse to abiotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationresponse to external stimuluscellular response to stimulusmacromolecule localizationestablishment of localizationinterspecies interaction between organismscell deathresponse to biotic stimulusimmune effector processresponse to chemicalresponse to abiotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationresponse to external stimuluscellular response to stimulusmacromolecule localizationestablishment of localizationinterspecies interaction between organismscell deathresponse to biotic stimulusimmune effector processresponse to chemicalresponse to abiotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationresponse to external stimuluscellular response to stimulusmacromolecule localizationestablishment of localizationinterspecies interaction between organismscell deathresponse to biotic stimulusimmune effector processresponse to chemicalresponse to abiotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationresponse to external stimuluscellular response to stimulusmacromolecule localizationestablishment of localizationinterspecies interaction between organismscell deathresponse to biotic stimulusimmune effector processresponse to chemicalresponse to abiotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationresponse to external stimuluscellular response to stimulusmacromolecule localizationestablishment of localizationinterspecies interaction between organismscell deathresponse to biotic stimulusimmune effector processresponse to chemicalresponse to abiotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationresponse to external stimuluscellular response to stimulusmacromolecule localizationestablishment of localizationinterspecies interaction between organismscell deathresponse to biotic stimulusimmune effector processresponse to chemicalresponse to abiotic stimuluscatabocatabolic processcellulcellular component organizationcellulcellular component biogenesiscellulcellular metabolic processprocesprocess utilizing autophagic mechanismnitrognitrogen compound metabolic processbiosynbiosynthetic processprimarprimary metabolic processorganiorganic substance metabolic processresponresponse to stresscell ccell communicationresponresponse to external stimuluscellulcellular response to stimulusmacrommacromolecule localizationestablestablishment of localizationintersinterspecies interaction between organismscell dcell deathresponresponse to biotic stimulusimmuneimmune effector processresponresponse to chemicalresponresponse to abiotic stimulus
protein bindingligase activitytransferase activityprotein bindingligase activitytransferase activityprotein bindingligase activitytransferase activityprotein bindingligase activitytransferase activityprotein bindingligase activitytransferase activityprotein bindingligase activitytransferase activityprotein bindingligase activitytransferase activityprotein bindingligase activitytransferase activityprotein bindingligase activitytransferase activityprotein bindingligase activitytransferase activityprotein bindingprotein bindingligase activityligase activitytransferase activitytransferase activity
cellcellcellcellcellcellcellcellcellcellcellcell
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IBA
 biological_processGO:0000422 autophagy of mitochondrion IEA
 biological_processGO:0006497 protein lipidation IEA
 biological_processGO:0006501 C-terminal protein lipidation IBA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006995 cellular response to nitrogen starvation IBA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016236 macroautophagy IEA
 biological_processGO:0031401 positive regulation of protein modification process IEA
 biological_processGO:0034727 piecemeal microautophagy of the nucleus IBA
 biological_processGO:0039521 suppression by virus of host autophagy IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0044805 late nucleophagy IBA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0071455 cellular response to hyperoxia IEA
 biological_processGO:0075044 autophagy of host cells involved in interaction with symbiont IEA
 cellular_componentGO:0000407 phagophore assembly site IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0019778 Atg12 activating enzyme activity ISS
 molecular_functionGO:0019779 Atg8 activating enzyme activity IBA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002345 ATG12 / autophagy related 12 / O94817* / Q9CQY1* / Ubiquitin-like protein ATG12 *  / complex / reaction
 ENSGALG00000004932 ATG7 / Q5ZKY2 / Ubiquitin-like modifier-activating enzyme ATG7 / O95352* / Q9D906* / autophagy related 7*  / complex
 ENSGALG00000015204 ATG3 / autophagy related 3 / Q9CPX6* / Q9NT62* / Ubiquitin-like-conjugating enzyme ATG3 *  / complex / reaction






 

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