ENSGALG00000005237


Gallus gallus
zincfingerFGD3domainfyverhohomologyphd-typeregulationdbldhpleckstrinph-likesuperfamilyringfyve-relatedproteinsignaltransductionmolecularfunctionguanyl-nucleotideexchangefactoractivitymetalionbindingnragesignalsdeath

Features
Gene ID: ENSGALG00000005237
  
Biological name :FGD3
  
Synonyms : FGD3 / FYVE, RhoGEF and PH domain containing 3
  
Possible biological names infered from orthology : Q5JSP0
  
Species: Gallus gallus
  
Chr. number: 12
Strand: -1
Band:
Gene start: 6711763
Gene end: 6813985
  
Corresponding Affymetrix probe sets: Gga.11591.1.S1_at (Chicken Array)   Gga.7018.1.S1_s_at (Chicken Array)   GgaAffx.21135.1.S1_s_at (Chicken Array)   GgaAffx.26455.1.A1_at (Chicken Array)   GgaAffx.26456.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044425
Ensembl peptide - ENSGALP00000008399
NCBI entrez gene - 415989     See in Manteia.
RefSeq - XM_414331
RefSeq - XM_015293410
RefSeq - XM_015293411
RefSeq - XM_004944555
RefSeq - XM_004944556
RefSeq - XM_004944557
RefSeq - XM_015293407
RefSeq - XM_015293408
RefSeq - XM_015293409
swissprot - F1P409
swissprot - A0A1D5NVP9
Ensembl - ENSGALG00000005237
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01079663.1ENSDARG00000099650Danio rerio
 FGD3ENSG00000127084Homo sapiens
 Fgd3ENSMUSG00000037946Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGD4 / FYVE, RhoGEF and PH domain containing 4 / Q91ZT5* / Q96M96* / FYVE, RhoGEF and PH domain-containing protein 4 *ENSGALG0000001293231
FGD6 / FYVE, RhoGEF and PH domain containing 6 / Q69ZL1* / Q6ZV73* / FYVE, RhoGEF and PH domain-containing protein 6 *ENSGALG0000001134221
FGD5 / FYVE, RhoGEF and PH domain containing 5 / Q6ZNL6*ENSGALG0000000854617
PLEKHF1 / pleckstrin homology and FYVE domain containing 1 / Q3TB82* / Q96S99* / Pleckstrin homology domain-containing family F member 1 *ENSGALG000000044746
PLEKHF2 / pleckstrin homology domain-containing family F member 2 / Q91WB4* / Q9H8W4* / pleckstrin homology and FYVE domain containing 2*ENSGALG000000402486


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000306  FYVE zinc finger
 IPR001849  Pleckstrin homology domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related


Gene Ontology (GO)
cell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcell communicationcellular response to stimuluscellular response to stimulusregulation of molecular functionregulation of molecular function
protein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingprotein bindingion bindingion binding
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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