ENSGALG00000005637


Gallus gallus
golgiGBF1celltransportproteinregulationlocalizationendoplasmicretrogradenetworkmembranesecdomainexchangefactorresponsevesicle-mediatedendosomeorganizationarfapparatusvesiclereticulumreticulum-golgiintermediatecompartmentphosphatidylinositol-bindingarmadillo-typefoldc-terminal

Features
Gene ID: ENSGALG00000005637
  
Biological name :GBF1
  
Synonyms : GBF1 / golgi brefeldin A resistant guanine nucleotide exchange factor 1
  
Possible biological names infered from orthology : Q92538
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 16830027
Gene end: 16931260
  
Corresponding Affymetrix probe sets: Gga.6986.1.S1_at (Chicken Array)   GgaAffx.26551.1.S1_s_at (Chicken Array)   GgaAffx.26551.2.S1_at (Chicken Array)   GgaAffx.26551.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009030
NCBI entrez gene - 423758     See in Manteia.
RefSeq - XM_015288459
RefSeq - XM_015288460
RefSeq - XM_015288461
RefSeq - XM_015288462
RefSeq - XM_015288458
swissprot - F1NGJ3
Ensembl - ENSGALG00000005637
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gbf1ENSDARG00000027016Danio rerio
 GBF1ENSG00000107862Homo sapiens
 Gbf1ENSMUSG00000025224Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PSD / pleckstrin and Sec7 domain containing / A5PKW4* / Q5DTT2* / Mus musculus pleckstrin and Sec7 domain containing (Psd), transcript variant 2, mRNA.*ENSGALG000000425519
ENSGALG000000154288
PSD2 / pleckstrin and Sec7 domain containing 2 / Q6P1I6* / Q9BQI7* / PH and SEC7 domain-containing protein 2 *ENSGALG000000308367


Protein motifs (from Interpro)
Interpro ID Name
 IPR000904  Sec7 domain
 IPR016024  Armadillo-type fold
 IPR023394  Sec7, C-terminal domain superfamily
 IPR032691  Guanine nucleotide exchange factor, N-terminal


Gene Ontology (GO)
immune responsecell activationimmune effector processestablishment of localizationcellular localizationcellular component organizationcell cycleresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimuluscell communicationmacromolecule localizationestablishment or maintenance of cell polarityregulation of molecular functionresponse to biotic stimulusbiosynthetic processcellular metabolic processimmune responsecell activationimmune effector processestablishment of localizationcellular localizationcellular component organizationcell cycleresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimuluscell communicationmacromolecule localizationestablishment or maintenance of cell polarityregulation of molecular functionresponse to biotic stimulusbiosynthetic processcellular metabolic processimmune responsecell activationimmune effector processestablishment of localizationcellular localizationcellular component organizationcell cycleresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimuluscell communicationmacromolecule localizationestablishment or maintenance of cell polarityregulation of molecular functionresponse to biotic stimulusbiosynthetic processcellular metabolic processimmune responsecell activationimmune effector processestablishment of localizationcellular localizationcellular component organizationcell cycleresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimuluscell communicationmacromolecule localizationestablishment or maintenance of cell polarityregulation of molecular functionresponse to biotic stimulusbiosynthetic processcellular metabolic processimmune responsecell activationimmune effector processestablishment of localizationcellular localizationcellular component organizationcell cycleresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimuluscell communicationmacromolecule localizationestablishment or maintenance of cell polarityregulation of molecular functionresponse to biotic stimulusbiosynthetic processcellular metabolic processimmune responsecell activationimmune effector processestablishment of localizationcellular localizationcellular component organizationcell cycleresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimuluscell communicationmacromolecule localizationestablishment or maintenance of cell polarityregulation of molecular functionresponse to biotic stimulusbiosynthetic processcellular metabolic processimmune responsecell activationimmune effector processestablishment of localizationcellular localizationcellular component organizationcell cycleresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimuluscell communicationmacromolecule localizationestablishment or maintenance of cell polarityregulation of molecular functionresponse to biotic stimulusbiosynthetic processcellular metabolic processimmune responsecell activationimmune effector processestablishment of localizationcellular localizationcellular component organizationcell cycleresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimuluscell communicationmacromolecule localizationestablishment or maintenance of cell polarityregulation of molecular functionresponse to biotic stimulusbiosynthetic processcellular metabolic processimmune responsecell activationimmune effector processestablishment of localizationcellular localizationcellular component organizationcell cycleresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimuluscell communicationmacromolecule localizationestablishment or maintenance of cell polarityregulation of molecular functionresponse to biotic stimulusbiosynthetic processcellular metabolic processimmune responsecell activationimmune effector processestablishment of localizationcellular localizationcellular component organizationcell cycleresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentcellular response to stimuluscell communicationmacromolecule localizationestablishment or maintenance of cell polarityregulation of molecular functionresponse to biotic stimulusbiosynthetic processcellular metabolic processimmune immune responsecell accell activationimmune immune effector processestabliestablishment of localizationcellulacellular localizationcellulacellular component organizationcell cycell cycleresponsresponse to external stimulusresponsresponse to chemicallocalizlocalization of cellmovemenmovement of cell or subcellular componentcellulacellular response to stimuluscell cocell communicationmacromomacromolecule localizationestabliestablishment or maintenance of cell polarityregulatregulation of molecular functionresponsresponse to biotic stimulusbiosyntbiosynthetic processcellulacellular metabolic process
protein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindingprotein bindinglipid bindinglipid bindingion bindingion binding
cellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellcellmembranemembraneorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0002263 cell activation involved in immune response IEA
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER IEA
 biological_processGO:0006895 Golgi to endosome transport IEA
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0016192 vesicle-mediated transport IBA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0034067 protein localization to Golgi apparatus IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IEA
 biological_processGO:0048205 COPI coating of Golgi vesicle IEA
 biological_processGO:0061162 establishment of monopolar cell polarity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070973 protein localization to endoplasmic reticulum exit site IEA
 biological_processGO:0090166 Golgi disassembly IEA
 biological_processGO:0097111 endoplasmic reticulum-Golgi intermediate compartment organization IEA
 biological_processGO:0098586 cellular response to virus IEA
 biological_processGO:1903409 reactive oxygen species biosynthetic process IEA
 biological_processGO:1903420 protein localization to endoplasmic reticulum tubular network IEA
 biological_processGO:2000008 regulation of protein localization to cell surface IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005801 cis-Golgi network IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031252 cell leading edge IEA
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IBA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Clathrin derived vesicle budding
VxPx cargo-targeting to cilium
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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