ENSDARG00000027016


Danio rerio

Features
Gene ID: ENSDARG00000027016
  
Biological name :gbf1
  
Synonyms : gbf1 / golgi brefeldin A resistant guanine nucleotide exchange factor 1
  
Possible biological names infered from orthology : Q92538
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 7575563
Gene end: 7749222
  
Corresponding Affymetrix probe sets: Dr.5933.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000046791
Ensembl peptide - ENSDARP00000143759
Ensembl peptide - ENSDARP00000120536
NCBI entrez gene - 566350     See in Manteia.
swissprot - A0A286Y9X1
swissprot - A0A0R4I9G6
swissprot - A0A0R4I9B8
ZFIN ID - ZDB-GENE-081107-54
Ensembl - ENSDARG00000027016
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GBF1ENSGALG00000005637Gallus gallus
 GBF1ENSG00000107862Homo sapiens
 Gbf1ENSMUSG00000025224Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
psd2 / pleckstrin and Sec7 domain containing 2 / Q6P1I6* / Q9BQI7* / PH and SEC7 domain-containing protein 2 *ENSDARG000000630368
psd3l / pleckstrin and Sec7 domain containing 3, likeENSDARG000001048208
si:ch211-150i13.1 / PSD* / Q5DTT2* / A5PKW4* / pleckstrin and Sec7 domain containing* / Mus musculus pleckstrin and Sec7 domain containing (Psd), transcript variant 2, mRNA.*ENSDARG000000781026
CABZ01068356.1 / PSD* / A5PKW4* / pleckstrin and Sec7 domain containing*ENSDARG000000767023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000904  Sec7 domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR023394  Sec7, C-terminal domain superfamily
 IPR032691  Guanine nucleotide exchange factor, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000099 brain vasculature brain vasculature hemorrhagic , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0001058 caudal fin caudal fin decreased length , abnormal
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 ZFA:0001094 whole organism whole organism increased amount , abnormal
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 ZFA:0001114 head head has fewer parts of type melanocyte , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel malformed , abnormal
intersegmental vessel blood vessel endothelial cell apoptotic , abnormal
intersegmental vessel hemorrhagic , abnormal
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 ZFA:0005020 central artery central artery malformed , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature blood vessel endothelial cell apoptotic , abnormal
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 ZFA:0005092 mesencephalic vein mesencephalic vein malformed , abnormal
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 ZFA:0005249 vasculature vasculature hemorrhagic , abnormal
vasculature hemorrhagic , ameliorated
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 ZFA:0009065 endothelial cell endothelial cell increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019581 uso1 / USO1 vesicle transport factor / O60763* / Q9Z1Z0* / USO1 vesicle docking factor*  / complex / reaction
 ENSDARG00000002792 arcn1a / archain 1a / ARCN1* / P48444* / Q5XJY5* / archain 1* / Coatomer subunit delta *  / complex / reaction
 ENSDARG00000031214 arcn1b / archain 1b / ARCN1* / P48444* / Q5XJY5* / archain 1* / Coatomer subunit delta *  / complex / reaction
 ENSDARG00000034823 copg2 / Q9PUE4 / coatomer protein complex, subunit gamma 2 / Q9QXK3* / Q9UBF2* / Coatomer subunit gamma-2 *  / complex / reaction
 ENSDARG00000056557 copb1 / Q66HV4 / coatomer protein complex, subunit beta 1 / P53618* / Q9JIF7* / Coatomer subunit beta *  / complex / reaction






 

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