ENSGALG00000006562


Gallus gallus
domainMCF2rhohomologyregulationsignaltransductionintracellularguanyl-nucleotideexchangefactoractivitydbldhcral-triolipidbindingguanine-nucleotidedissociationstimulatorcdcconservedsiteshpleckstrinph-likesuperfamilyspectrinalpha-actininproteinmolecular

Features
Gene ID: ENSGALG00000006562
  
Biological name :MCF2
  
Synonyms : MCF2 / MCF.2 cell line derived transforming sequence
  
Possible biological names infered from orthology : P10911
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 5064752
Gene end: 5112915
  
Corresponding Affymetrix probe sets: GgaAffx.4086.1.S1_at (Chicken Array)   GgaAffx.4086.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000010580
Ensembl peptide - ENSGALP00000044178
NCBI entrez gene - 422253     See in Manteia.
RefSeq - XM_015278485
RefSeq - XM_015278484
swissprot - E1BWQ1
swissprot - A0A1D5NV05
Ensembl - ENSGALG00000006562
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcf2aENSDARG00000022895Danio rerio
 mcf2bENSDARG00000056603Danio rerio
 MCF2ENSG00000101977Homo sapiens
 Mcf2ENSMUSG00000031139Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MCF2L / MCF.2 cell line derived transforming sequence like / O15068*ENSGALG0000001683448
MCF2L2 / MCF.2 cell line derived transforming sequence-like 2 / Q86YR7*ENSGALG0000000874447
KALRN / kalirin RhoGEF kinase / A2CG49* / O60229* / Kalirin *ENSGALG0000001174426
TRIO / trio Rho guanine nucleotide exchange factor / O75962* / Q0KL02* / Triple functional domain protein *ENSGALG0000003149526
A1L390* / Q4VAC9* / PLEKHG3* / pleckstrin homology and RhoGEF domain containing G3* / Pleckstrin homology domain-containing family G member 3 *ENSGALG000000361999
PLEKHG1 / pleckstrin homology and RhoGEF domain containing G1 / Q9ULL1*ENSGALG000000123957
A1L390* / Q4VAC9* / PLEKHG3* / pleckstrin homology and RhoGEF domain containing G3* / Pleckstrin homology domain-containing family G member 3 *ENSGALG000000374097


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR018159  Spectrin/alpha-actinin


Gene Ontology (GO)
cell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcellular response to stimulusregulation of molecular functioncell communicationcell communicationcellular response to stimuluscellular response to stimulusregulation of molecular functionregulation of molecular function
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellcellcellcellcellcellcellcellcellcellcellcell
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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