ENSGALG00000006602


Gallus gallus
bindingSYT8vesiclemembraneexocytosiscalciumendocytosissynaptotagminsynapticcalcium-dependentclathrin-mediatedcdomainfusionacrosomereactionregulationion-dependention-regulatedneurotransmittercytoplasmplasmaintegralcomponentionphospholipidsyntaxinclathrinproteincargorecognition

Features
Gene ID: ENSGALG00000006602
  
Biological name :SYT8
  
Synonyms : synaptotagmin 8 / SYT8
  
Possible biological names infered from orthology : Q8NBV8 / Q9R0N6 / synaptotagmin VIII
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 14108059
Gene end: 14112076
  
Corresponding Affymetrix probe sets: Gga.12005.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000010643
NCBI entrez gene - 423095     See in Manteia.
RefSeq - XM_015286685
swissprot - F1P4J5
Ensembl - ENSGALG00000006602
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SYT8ENSG00000149043Homo sapiens
 Syt8ENSMUSG00000031098Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SYT2 / synaptotagmin 2 / Q8N9I0* / synaptotagmin II*ENSGALG0000002603353
SYT1 / P47191 / Synaptotagmin-1 / P46096* / P21579* / synaptotagmin I*ENSGALG0000004109452
SYT9 / synaptotagmin 9 / Q86SS6* / Q9R0N9*ENSGALG0000000526533
SYT10 / synaptotagmin 10 / Q6XYQ8* / Q9R0N4* / synaptotagmin X*ENSGALG0000001291133
SYT7 / synaptotagmin 7 / O43581* / Q9R0N7*ENSGALG0000004313933
SYT6 / synaptotagmin 6 / Q5T7P8* / Q9R0N8* / synaptotagmin VI*ENSGALG0000000196832
SYT4 / synaptotagmin 4 / P40749* / Q9H2B2*ENSGALG0000004262630
SYT11 / synaptotagmin 11 / Q9BT88* / Q9R0N3*ENSGALG0000001464629


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR015428  Synaptotagmin 1/2


Gene Ontology (GO)
establishment of localizationcellular component organizationcellular localizationcell communicationregulation of biological qualityestablishment of localizationcellular component organizationcellular localizationcell communicationregulation of biological qualityestablishment of localizationcellular component organizationcellular localizationcell communicationregulation of biological qualityestablishment of localizationcellular component organizationcellular localizationcell communicationregulation of biological qualityestablishment of localizationcellular component organizationcellular localizationcell communicationregulation of biological qualityestablishment of localizationcellular component organizationcellular localizationcell communicationregulation of biological qualityestablishment of localizationcellular component organizationcellular localizationcell communicationregulation of biological qualityestablishment of localizationcellular component organizationcellular localizationcell communicationregulation of biological qualityestablishment of localizationcellular component organizationcellular localizationcell communicationregulation of biological qualityestablishment of localizationcellular component organizationcellular localizationcell communicationregulation of biological qualityestablishment of localizatioestablishment of localizationcellular component organizatcellular component organizationcellular localizationcellular localizationcell communicationcell communicationregulation of biological quaregulation of biological quality
ion bindinglipid bindingprotein bindingion bindinglipid bindingprotein bindingion bindinglipid bindingprotein bindingion bindinglipid bindingprotein bindingion bindinglipid bindingprotein bindingion bindinglipid bindingprotein bindingion bindinglipid bindingprotein bindingion bindinglipid bindingprotein bindingion bindinglipid bindingprotein bindingion bindinglipid bindingprotein bindingion bindingion bindinglipid bindinglipid bindingprotein bindingprotein binding
cellmembranesynapseorganellecellmembranesynapseorganellecellmembranesynapseorganellecellmembranesynapseorganellecellmembranesynapseorganellecellmembranesynapseorganellecellmembranesynapseorganellecellmembranesynapseorganellecellmembranesynapseorganellecellmembranesynapseorganellecellcellmembranemembranesynapsesynapseorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0007340 acrosome reaction IEA
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IBA
 biological_processGO:0048488 synaptic vesicle endocytosis IBA
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IBA
 cellular_componentGO:0031982 vesicle IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IBA
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0030276 clathrin binding IBA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006602 SYT8 / synaptotagmin 8 / Q8NBV8* / Q9R0N6* / synaptotagmin VIII*  / complex






 

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