ENSGALG00000007963


Gallus gallus

Features
Gene ID: ENSGALG00000007963
  
Biological name :NFATC2
  
Synonyms : NFATC2 / nuclear factor of activated T cells 2
  
Possible biological names infered from orthology : nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 / Q13469 / Q60591
  
Species: Gallus gallus
  
Chr. number: 20
Strand: 1
Band:
Gene start: 13405791
Gene end: 13471470
  
Corresponding Affymetrix probe sets: GgaAffx.4982.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000012917
Ensembl peptide - ENSGALP00000052605
NCBI entrez gene - 419346     See in Manteia.
RefSeq - XM_417509
RefSeq - XM_004947259
RefSeq - XM_015296517
RefSeq - XM_004947255
RefSeq - XM_004947256
swissprot - E1C473
swissprot - A0A1D5PIH2
Ensembl - ENSGALG00000007963
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfatc2aENSDARG00000100927Danio rerio
 nfatc2bENSDARG00000079972Danio rerio
 NFATC2ENSG00000101096Homo sapiens
 Nfatc2ENSMUSG00000027544Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFATC1 / nuclear factor of activated T cells 1 / O95644* / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1*ENSGALG0000004253450
NFATC3 / nuclear factor of activated T cells 3 / Q12968* / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3*ENSGALG0000000339643
NFAT5 / nuclear factor of activated T-cells 5 / O94916* / Q9WV30*ENSGALG0000003930028


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR008366  Nuclear factor of activated T cells (NFAT)
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR032397  Rel homology dimerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014904 myotube cell development IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:1901741 positive regulation of myoblast fusion IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0044798 nuclear transcription factor complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
FCERI mediated Ca+2 mobilization
CLEC7A (Dectin-1) induces NFAT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005243 PPP3CB / Gallus gallus protein phosphatase 3 catalytic subunit beta (PPP3CB), mRNA. / P48453* / P16298* / protein phosphatase 3 catalytic subunit beta* / protein phosphatase 3, catalytic su...  / complex
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / complex
 ENSGALG00000039498 PPP3CA / protein phosphatase 3 catalytic subunit alpha / P63328* / Q08209* / protein phosphatase 3, catalytic subunit, alpha isoform*  / complex






 

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