Manteia

ENSGALG00000039498

Gallus gallus

Features

Gene ID:	ENSGALG00000039498

Biological name :	PPP3CA

Synonyms :	PPP3CA / protein phosphatase 3 catalytic subunit alpha

Possible biological names infered from orthology :	P63328 / protein phosphatase 3, catalytic subunit, alpha isoform / Q08209

Species:	Gallus gallus

Chr. number:	4
Strand:	-1
Band:
Gene start:	60690568
Gene end:	60796629

Corresponding Affymetrix probe sets:	Gga.1322.1.S1_at (Chicken Array) Gga.1322.1.S1_a_at (Chicken Array) Gga.1322.2.A1_at (Chicken Array) Gga.1322.2.S1_x_at (Chicken Array) Gga.3869.1.S1_at (Chicken Array)

Cross references:	Ensembl peptide - ENSGALP00000047388 NCBI entrez gene - 395113 See in Manteia. RefSeq - XM_015285619 RefSeq - XM_015285620 RefSeq - XM_015285621 RefSeq - XM_015285622 RefSeq - XM_015285623 RefSeq - XM_015285618 swissprot - A0A1D5P3Y2 Ensembl - ENSGALG00000039498

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ppp3ca	ENSDARG00000004988	Danio rerio
ppp3cb	ENSDARG00000025106	Danio rerio
PPP3CA	ENSG00000138814	Homo sapiens
P63328	ENSMUSG00000028161	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
PPP3CB / Gallus gallus protein phosphatase 3 catalytic subunit beta (PPP3CB), mRNA. / P48453* / P16298* / protein phosphatase 3 catalytic subunit beta* / protein phosphatase 3, catalytic su...	ENSGALG00000005243	82

Protein motifs (from Interpro)

Interpro ID	Name
IPR004843	Calcineurin-like phosphoesterase domain, ApaH type
IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052	Metallo-dependent phosphatase-like

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000082	G1/S transition of mitotic cell cycle	IEA
biological_process	GO:0006470	protein dephosphorylation	IEA
biological_process	GO:0006606	protein import into nucleus	IEA
biological_process	GO:0006816	calcium ion transport	IEA
biological_process	GO:0010613	positive regulation of cardiac muscle hypertrophy	IEA
biological_process	GO:0010628	positive regulation of gene expression	IEA
biological_process	GO:0010629	negative regulation of gene expression	IEA
biological_process	GO:0014883	transition between fast and slow fiber	IEA
biological_process	GO:0014898	cardiac muscle hypertrophy in response to stress	IEA
biological_process	GO:0016311	dephosphorylation	IEA
biological_process	GO:0019722	calcium-mediated signaling	IEA
biological_process	GO:0033173	calcineurin-NFAT signaling cascade	IEA
biological_process	GO:0033555	multicellular organismal response to stress	IEA
biological_process	GO:0035562	negative regulation of chromatin binding	IEA
biological_process	GO:0035690	cellular response to drug	IEA
biological_process	GO:0045807	positive regulation of endocytosis	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0048741	skeletal muscle fiber development	IEA
biological_process	GO:0050774	negative regulation of dendrite morphogenesis	IEA
biological_process	GO:0050804	modulation of chemical synaptic transmission	IEA
biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IEA
biological_process	GO:0051592	response to calcium ion	IEA
biological_process	GO:0060079	excitatory postsynaptic potential	IEA
biological_process	GO:1903244	positive regulation of cardiac muscle hypertrophy in response to stress	IEA
biological_process	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA	IEA
biological_process	GO:1905205	positive regulation of connective tissue replacement	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005955	calcineurin complex	IEA
cellular_component	GO:0009898	cytoplasmic side of plasma membrane	IEA
cellular_component	GO:0030018	Z disc	IEA
cellular_component	GO:0043197	dendritic spine	IEA
molecular_function	GO:0004721	phosphoprotein phosphatase activity	IEA
molecular_function	GO:0005516	calmodulin binding	IEA
molecular_function	GO:0008144	drug binding	IEA
molecular_function	GO:0016018	cyclosporin A binding	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0019899	enzyme binding	IEA
molecular_function	GO:0033192	calmodulin-dependent protein phosphatase activity	IEA
molecular_function	GO:0046983	protein dimerization activity	IEA

Pathways (from Reactome)

Pathway description

FCERI mediated Ca+2 mobilization

Ca2+ pathway

CLEC7A (Dectin-1) induces NFAT activation

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSGALG00000007963	NFATC2 / nuclear factor of activated T cells 2 / Q13469* / Q60591* / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2*	/ complex
ENSGALG00000010023	CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*	/ complex
ENSGALG00000042534	NFATC1 / nuclear factor of activated T cells 1 / O95644* / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1*	/ complex

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr