ENSGALG00000008028


Gallus gallus

Features
Gene ID: ENSGALG00000008028
  
Biological name :LIF
  
Synonyms : LIF / LIF, interleukin 6 family cytokine
  
Possible biological names infered from orthology : Leukemia inhibitory factor / P09056 / P15018
  
Species: Gallus gallus
  
Chr. number: 15
Strand: 1
Band:
Gene start: 10920686
Gene end: 10925689
  
Corresponding Affymetrix probe sets: GgaAffx.21379.1.S1_at (Chicken Array)   GgaAffx.5026.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013010
swissprot - F1N9H9
Ensembl - ENSGALG00000008028
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LIFENSG00000128342Homo sapiens
 LifENSMUSG00000034394Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001581  Leukemia inhibitory factor /oncostatin
 IPR003624  Leukemia inhibitory factor
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045651 positive regulation of macrophage differentiation IEA
 biological_processGO:0045835 negative regulation of meiotic nuclear division IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0046888 negative regulation of hormone secretion IEA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0048644 muscle organ morphogenesis IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0048861 leukemia inhibitory factor signaling pathway IEA
 biological_processGO:0048863 stem cell differentiation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0060426 lung vasculature development IEA
 biological_processGO:0060463 lung lobe morphogenesis IEA
 biological_processGO:0060707 trophoblast giant cell differentiation IEA
 biological_processGO:0060708 spongiotrophoblast differentiation IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
 biological_processGO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1901676 positive regulation of histone H3-K27 acetylation IEA
 biological_processGO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005146 leukemia inhibitory factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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