Manteia - Molecule gene

ENSMUSG00000034394

Mus musculus

Features

Gene ID:	ENSMUSG00000034394

Biological name :	Lif

Synonyms :	Leukemia inhibitory factor / Lif / P09056

Possible biological names infered from orthology :	LIF, interleukin 6 family cytokine / P15018

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	A1
Gene start:	4257557
Gene end:	4272514

Corresponding Affymetrix probe sets:	10373918 (MoGene1.0st) 1421207_at (Mouse Genome 430 2.0 Array) 1450160_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000036853 Ensembl peptide - ENSMUSP00000067066 NCBI entrez gene - 16878 See in Manteia. MGI - MGI:96787 RefSeq - XM_006514544 RefSeq - NM_001039537 RefSeq - NM_008501 RefSeq - XM_006514542 RefSeq - XM_006514543 RefSeq Peptide - NP_001034626 RefSeq Peptide - NP_032527 swissprot - P09056 swissprot - F8WH42 Ensembl - ENSMUSG00000034394

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
LIF	ENSGALG00000008028	Gallus gallus
LIF	ENSG00000128342	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001581	Leukemia inhibitory factor /oncostatin
IPR003624	Leukemia inhibitory factor
IPR009079	Four-helical cytokine-like, core
IPR019827	Leukemia inhibitory factor /oncostatin, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001974	blood vessel remodeling	IGI
biological_process	GO:0006955	immune response	IEA
biological_process	GO:0007260	tyrosine phosphorylation of STAT protein	IDA
biological_process	GO:0007566	embryo implantation	IMP
biological_process	GO:0008284	positive regulation of cell proliferation	IEA
biological_process	GO:0008285	negative regulation of cell proliferation	IGI
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0010628	positive regulation of gene expression	IGI
biological_process	GO:0019827	stem cell population maintenance	IGI
biological_process	GO:0030324	lung development	IGI
biological_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IEA
biological_process	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	IEA
biological_process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IEA
biological_process	GO:0043410	positive regulation of MAPK cascade	IEA
biological_process	GO:0045595	regulation of cell differentiation	IGI
biological_process	GO:0045651	positive regulation of macrophage differentiation	IEA
biological_process	GO:0045835	negative regulation of meiotic nuclear division	IDA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0046697	decidualization	IMP
biological_process	GO:0046888	negative regulation of hormone secretion	IEA
biological_process	GO:0048286	lung alveolus development	IGI
biological_process	GO:0048644	muscle organ morphogenesis	IMP
biological_process	GO:0048666	neuron development	IGI
biological_process	GO:0048711	positive regulation of astrocyte differentiation	IDA
biological_process	GO:0048861	leukemia inhibitory factor signaling pathway	IEA
biological_process	GO:0048863	stem cell differentiation	IDA
biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0060135	maternal process involved in female pregnancy	IMP
biological_process	GO:0060426	lung vasculature development	IGI
biological_process	GO:0060463	lung lobe morphogenesis	IGI
biological_process	GO:0060707	trophoblast giant cell differentiation	IGI
biological_process	GO:0060708	spongiotrophoblast differentiation	IGI
biological_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IGI
biological_process	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IEA
biological_process	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	IEA
biological_process	GO:1900182	positive regulation of protein localization to nucleus	IEA
biological_process	GO:1901676	positive regulation of histone H3-K27 acetylation	IEA
biological_process	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	IDA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005829	cytosol	IEA
molecular_function	GO:0005102	signaling receptor binding	IEA
molecular_function	GO:0005125	cytokine activity	IEA
molecular_function	GO:0005146	leukemia inhibitory factor receptor binding	IEA
molecular_function	GO:0008083	growth factor activity	ISO

Pathways (from Reactome)

Pathway description

IL-6-type cytokine receptor ligand interactions

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1 Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0000061	fragile skeleton	"easily damaged or broken bones" [J:14208]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0000382	underdeveloped hair follicles	"arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0000734	muscle hypoplasia	"underdevelopment or atrophy of muscle" [J:15108]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0000875	abnormal cerebellar Purkinje cell layer	"any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv
MP:0000939	reduced motor neuron number	"fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Cacna1a^tg-rol/Cacna1a⁺ Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv
MP:0000952	abnormal CNS glia	"anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001120	abnormal uterus morphology	"malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il11ra1^tm2Gos/Il11ra1^tm2Gos Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Lif^tm1Cgre/Lif^tm1Cgre Genetic Background: involves: MF1
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0001177	atelectasis	"collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0001179	thicker alveolar septa		Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0001218	thin epidermis	"reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Il11ra1^tm2Gos/Il11ra1^tm2Gos Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1 Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Itga2b^tm1Tlr/Itga2b^tm1Tlr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/c) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) Allelic Composition: Lif^tm1Phb/Lif⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0001492	piloerection	"the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0001541	abnormal osteoclast function	"reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Fosl2^tm2Wag/Fosl2^tm2Wag,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001654	hepatic necrosis	"pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0001728	failure of implantation	"inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]	Show Allelic Composition: Il11ra1^tm2Gos/Il11ra1^tm2Gos Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Lif^tm1Phb/Lif^tm1Phb Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il11ra1^tm2Gos/Il11ra1^tm2Gos Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0001881	abnormal mammary gland physiology	"aberrant function of of the milk-secreting gland that lies within the breast" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cacna1a^tg-rol/Cacna1a⁺ Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Il11ra1^tm2Gos/Il11ra1^tm2Gos Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Lif^tm1Phb/Lif^tm1Phb Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0002182	abnormal astrocyte morphology	"anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002270	abnormal alveoli morphology	"any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0002275	abnormal type II pneumocyte morphology	"any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0002446	abnormal macrophage morphology	"anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lif^tm1Cgre/Lif^tm1Cgre Genetic Background: involves: MF1
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ptgs2^tm1Jed/Ptgs2^tm1Jed Genetic Background: involves: 129S7/SvEvBrd * CD-1
MP:0002655	abnormal keratinocyte morphology	"structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0002664	decreased circulating adrenocorticotropin level	"decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cacna1a^tg-rol/Cacna1a⁺ Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII
MP:0002792	abnormal retinal vascularization	"malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002941	increased circulating alanine transaminase level	"increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0003634	abnormal glia	"malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6
MP:0003651	abnormal axon outgrowth	"defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]	Show Allelic Composition: Cntf^tm1Mpin/Cntf^tm1Mpin,Lif^tm1Phb/Lif^tm1Phb Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003658	abnormal capillaries	"malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]	Show Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0003723	abnormal long bone morphology	"malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0003888	liver hemorrhage	"bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0004702	increased circulating insulin-like growth factor I level	"increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptgs2^tm1Jed/Ptgs2^tm1Jed Genetic Background: involves: 129S7/SvEvBrd * CD-1 Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0004810	decreased hematopoietic stem cell number	"reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lif^tm1Phb/Lif^tm1Phb Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Lif^tm1Phb/Lif⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0004950	abnormal brain vasculature	"any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0004982	abnormal osteoclast morphology	"any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fosl2^tm2Wag/Fosl2^tm2Wag,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004984	increased osteoclast cell number	"greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fosl2^tm2Wag/Fosl2^tm2Wag,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004992	increased bone resorption	"greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fosl2^tm2Wag/Fosl2^tm2Wag,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005011	increased eosinophil count	"greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lif^tm1Cgre/Lif^tm1Cgre Genetic Background: involves: MF1
MP:0005036	diarrhea	"abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0005039	hypoxia	"reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fosl2^tm2Wag/Fosl2^tm2Wag,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005088	increased acute inflammation	"greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0005095	decreased T cell proliferation	"reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lif^tm1Phb/Lif^tm1Phb Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Lif^tm1Phb/Lif⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0005137	increased growth hormone level	"greater than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1 Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0005165	increased susceptibility to injury	"greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cntf^tm1Mpin/Cntf^tm1Mpin,Lif^tm1Phb/Lif^tm1Phb Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005166	decreased susceptiblity to injury	"less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6
MP:0005343	increased circulating aspartate transaminase level	"greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0005669	increased circulating leptin level	"greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Ptgs2^tm1Jed/Ptgs2^tm1Jed Genetic Background: involves: 129S7/SvEvBrd * CD-1 Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0006086	decreased body mass index	"less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0006269	abnormal mammary gland growth during pregnancy	"anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Cacna1a^tg-rol/Cacna1a⁺ Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII
MP:0006271	abnormal involution of the mammary gland	"anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Cacna1a^tg-rol/Cacna1a⁺ Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII
MP:0008396	abnormal osteoclast differentiation	"atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fosl2^tm2Wag/Fosl2^tm2Wag,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0008596	increased circulating interleukin-6 level	"increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0008641	increased circulating interleukin-1 beta level	"increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0008661	decreased interleukin-10 secretion	"reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0008735	increased susceptibility to endotoxin shock	"more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0008813	decreased common myeloid progenitor cell number	"reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lif^tm1Phb/Lif^tm1Phb Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0008973	decreased erythroid progenitor cell number	"reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lif^tm1Phb/Lif^tm1Phb Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Lif^tm1Phb/Lif⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0009117	abnormal white fat cell morphology	"any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0009283	decreased gonadal fat pad weight	"less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0009394	increased uterine NK cell number	"increased number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; uNK cells contribute to uterine decidualization and are recruited to implantation sites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lif^tm1Cgre/Lif^tm1Cgre Genetic Background: involves: MF1
MP:0009503	abnormal mammary gland duct morphology	"any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cacna1a^tg-rol/Cacna1a⁺ Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII
MP:0009506	abnormal mammary gland alveolus morphology	"any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cacna1a^tg-rol/Cacna1a⁺ Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII
MP:0009660	abnormal induced retinal neovascularization	"any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0009662	abnormal uterine receptivity	"any alteration in the time sensitive process of uterine differentiation that occurs in response to implantation competent blastocysts and precedes and is necessary for embryo implantation" [PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]	Show Allelic Composition: Lif^tm1Phb/Lif^tm1Phb Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0009665	abnormal embryo apposition	"any anomaly that prevents the initial positioning of the blastocyst trophoblast and uterine luminal epithelium causing the blastocyst to fail to orientate correctly along the uterine wall" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]	Show Allelic Composition: Lif^tm1Phb/Lif^tm1Phb Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0009666	abnormal embryo attachment	"any anomaly in the process whereby the blastocyst anchors to the uterine luminal epithelium and cannot be dislodged by flushing" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]	Show Allelic Composition: Lif^tm1Phb/Lif^tm1Phb Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0009788	increased susceptibility to bacterial infection induced morbidity/mortality	"increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0009946	abnormal olfactory bulb layer morphology	"any structural anomaly of the laminar structure of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0009947	abnormal olfactory bulb external plexiform layer morphology	"any structural anomaly of the part of the olfactory bulb, lying superior to the mitral cell layer and inferior to the glomerular layer, which is mostly neuropil composed almost entirely of mitral and tufted cell dendrites, granule cell dendrites and their synaptic inputs" [NLX:nlx_96 "NeuroLex.org"]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0009951	abnormal olfactory bulb mitral cell layer morphology		Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0009954	abnormal mitral cell morphology	"any structural anomaly of the large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0010019	liver vascular congestion	"obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0010180	increased susceptibility to weight loss	"greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0010214	abnormal circulating serum amyloid protein level	"deviation from the normal blood levels of an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis" [MESH:D12.776.049.790, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1^tm1Arge/Igf1⁺,Lif^tm1Stw/Lif⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1
MP:0010810	increased type II pneumocyte number	"greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0010817	absent type I pneumocytes	"absence of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0010876	decreased bone volume	"reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fosl2^tm2Wag/Fosl2^tm2Wag,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge,Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1
MP:0020161	increased vascular endothelial cell proliferation	"increase in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Lif^tm1Stw/Lif^tm1Stw Genetic Background: involves: 129S1/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000024789	Jak2 / Janus kinase 2 / O60674*	/ complex / reaction
ENSMUSG00000054263	Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*	/ complex / reaction
ENSMUSG00000021756	Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*	/ complex / reaction
ENSMUSG00000028530	Jak1 / Janus kinase 1 / P23458*	/ complex / reaction

0 s.

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