ENSGALG00000008162


Gallus gallus
dnaFBXO18helicasebindingactivityregulationrepairresponsedamagehydrolasedouble-strandbreakviahomologousrecombinationproteinreplicationforkchromatinsignalinguvrdreptypef-boxdomainuvrd-likec-terminalp-loopcontainingnucleosidetriphosphate

Features
Gene ID: ENSGALG00000008162
  
Biological name :FBXO18
  
Synonyms : F1ND48 / F-box DNA helicase 1 / FBXO18
  
Possible biological names infered from orthology : F-box protein, helicase, 18 / Mus musculus F-box protein 18 (Fbxo18), transcript variant 5, mRNA. / Q8K2I9 / Q8NFZ0
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 1020496
Gene end: 1042028
  
Corresponding Affymetrix probe sets: GgaAffx.5116.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013249
NCBI entrez gene - 416687     See in Manteia.
RefSeq - XM_015283696
RefSeq - NM_001080210
RefSeq - XM_015283583
RefSeq - XM_015283640
RefSeq - XM_015283532
RefSeq Peptide - NP_001073679
swissprot - F1ND48
Ensembl - ENSGALG00000008162
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxo18ENSDARG00000062983Danio rerio
 FBXO18ENSG00000134452Homo sapiens
 Fbxo18ENSMUSG00000058594Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000212  DNA helicase, UvrD/REP type
 IPR001810  F-box domain
 IPR014017  UvrD-like DNA helicase, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
nitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscatabolic processcell deathbiosynthetic processcellular component organizationregulation of molecular functionresponse to endogenous stimulusresponse to biotic stimuluscell communicationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscatabolic processcell deathbiosynthetic processcellular component organizationregulation of molecular functionresponse to endogenous stimulusresponse to biotic stimuluscell communicationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscatabolic processcell deathbiosynthetic processcellular component organizationregulation of molecular functionresponse to endogenous stimulusresponse to biotic stimuluscell communicationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscatabolic processcell deathbiosynthetic processcellular component organizationregulation of molecular functionresponse to endogenous stimulusresponse to biotic stimuluscell communicationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscatabolic processcell deathbiosynthetic processcellular component organizationregulation of molecular functionresponse to endogenous stimulusresponse to biotic stimuluscell communicationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscatabolic processcell deathbiosynthetic processcellular component organizationregulation of molecular functionresponse to endogenous stimulusresponse to biotic stimuluscell communicationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscatabolic processcell deathbiosynthetic processcellular component organizationregulation of molecular functionresponse to endogenous stimulusresponse to biotic stimuluscell communicationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscatabolic processcell deathbiosynthetic processcellular component organizationregulation of molecular functionresponse to endogenous stimulusresponse to biotic stimuluscell communicationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscatabolic processcell deathbiosynthetic processcellular component organizationregulation of molecular functionresponse to endogenous stimulusresponse to biotic stimuluscell communicationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscatabolic processcell deathbiosynthetic processcellular component organizationregulation of molecular functionresponse to endogenous stimulusresponse to biotic stimuluscell communicationnitrogen cnitrogen compound metabolic processresponse tresponse to stresscellular mcellular metabolic processprimary meprimary metabolic processorganic suorganic substance metabolic processcellular rcellular response to stimuluscatabolic catabolic processcell deathcell deathbiosynthetbiosynthetic processcellular ccellular component organizationregulationregulation of molecular functionresponse tresponse to endogenous stimulusresponse tresponse to biotic stimuluscell commucell communication
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on DNAhydrolase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on DNAhydrolase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on DNAhydrolase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on DNAhydrolase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on DNAhydrolase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on DNAhydrolase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on DNAhydrolase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on DNAhydrolase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on DNAhydrolase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on DNAhydrolase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic coorganic cyclic compound bindingheterocyclic compheterocyclic compound bindingsmall molecule bismall molecule bindingcatalytic activitcatalytic activity, acting on DNAhydrolase activithydrolase activityion bindingion bindingcarbohydrate dericarbohydrate derivative bindingdrug bindingdrug binding
cellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellcellorganelleorganelleprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0000737 DNA catabolic process, endonucleolytic IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0008219 cell death IEA
 biological_processGO:0016567 protein ubiquitination ISS
 biological_processGO:0031297 replication fork processing IMP
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0035562 negative regulation of chromatin binding IEA
 biological_processGO:0048478 replication fork protection IEA
 biological_processGO:0072429 response to intra-S DNA damage checkpoint signaling IEA
 biological_processGO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:2000042 negative regulation of double-strand break repair via homologous recombination IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015616 DNA translocase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043138 3"-5" DNA helicase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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