ENSGALG00000008253


Gallus gallus
transcriptionTBX5bindingdevelopmentregulationmorphogenesisfactorrnapolymeraseiidnacardiaccellsequence-specificmuscleproliferationseptumdna-templatedlimbactivityt-boxdna-bindingformationventricularatrialheartembryonicforelimbcardioblastdifferentiationactin

Features
Gene ID: ENSGALG00000008253
  
Biological name :TBX5
  
Synonyms : Q9PWE8 / T-box transcription factor TBX5 / TBX5
  
Possible biological names infered from orthology : P70326 / Q99593 / T-box 5
  
Species: Gallus gallus
  
Chr. number: 15
Strand: 1
Band:
Gene start: 12344444
Gene end: 12421127
  
Corresponding Affymetrix probe sets: Gga.961.1.S1_at (Chicken Array)   Gga.961.2.S1_at (Chicken Array)   Gga.961.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000062598
Ensembl peptide - ENSGALP00000013419
NCBI entrez gene - 373988     See in Manteia.
RefSeq - XM_015294832
RefSeq - NM_204173
RefSeq - XM_015294830
RefSeq - XM_015294831
RefSeq Peptide - NP_989504
swissprot - R9PXM9
swissprot - A0A1L1RUU6
swissprot - Q9PWE8
Ensembl - ENSGALG00000008253
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbx5aENSDARG00000024894Danio rerio
 tbx5bENSDARG00000092060Danio rerio
 TBX5ENSG00000089225Homo sapiens
 Tbx5ENSMUSG00000018263Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TBX4 / T-box 4 / P57082* / P70325*ENSGALG0000000528555
TBX2 / T-box 2 / Q13207* / Q60707* / T-box transcription factor TBX2 *ENSGALG0000003429731
TBX3 / T-box 3 / O15119* / P70324*ENSGALG0000003604331
TBX20 / Q8UW76 / T-box transcription factor TBX20 / Q9UMR3* / Q9ES03* / T-box 20*ENSGALG0000003209727
TBX18 / T-box transcription factor TBX18 / O95935* / T-box 18*ENSGALG0000003278927
TBX1 / T-box 1 / O43435*ENSGALG0000004118227
TBX6 / T-box-containing protein TBX6L / O95947* / P70327* / T-box 6* / T-box transcription factor TBX6 *ENSGALG0000000637425
TBX22 / T-box 22 / Q8K402* / Q9Y458*ENSGALG0000000409324
TBX10* / O75333* / Q810F8* / T-box 10* / T-box transcription factor TBX10 *ENSGALG0000003876722
TBX15 / T-box 15 / O70306* / Q96SF7* / T-box transcription factor TBX15 *ENSGALG0000001477618


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site


Gene Ontology (GO)
anatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationlocalization of cellmovement of cell or subcellular componentresponse to chemicalcellular developmental processmuscle cell proliferationdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationlocalization of cellmovement of cell or subcellular componentresponse to chemicalcellular developmental processmuscle cell proliferationdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationlocalization of cellmovement of cell or subcellular componentresponse to chemicalcellular developmental processmuscle cell proliferationdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationlocalization of cellmovement of cell or subcellular componentresponse to chemicalcellular developmental processmuscle cell proliferationdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationlocalization of cellmovement of cell or subcellular componentresponse to chemicalcellular developmental processmuscle cell proliferationdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationlocalization of cellmovement of cell or subcellular componentresponse to chemicalcellular developmental processmuscle cell proliferationdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationlocalization of cellmovement of cell or subcellular componentresponse to chemicalcellular developmental processmuscle cell proliferationdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationlocalization of cellmovement of cell or subcellular componentresponse to chemicalcellular developmental processmuscle cell proliferationdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationlocalization of cellmovement of cell or subcellular componentresponse to chemicalcellular developmental processmuscle cell proliferationdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationlocalization of cellmovement of cell or subcellular componentresponse to chemicalcellular developmental processmuscle cell proliferationdevelopmental growthanatomicalanatomical structure developmentnitrogen cnitrogen compound metabolic processbiosynthetbiosynthetic processcellular mcellular metabolic processprimary meprimary metabolic processorganic suorganic substance metabolic processcell commucell communicationlocalizatilocalization of cellmovement omovement of cell or subcellular componentresponse tresponse to chemicalcellular dcellular developmental processmuscle celmuscle cell proliferationdevelopmendevelopmental growth
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor acDNA-binding transcription factor activityprotein bindingprotein binding
cellorganellesupramolecular complexprotein-containing complexcellorganellesupramolecular complexprotein-containing complexcellorganellesupramolecular complexprotein-containing complexcellorganellesupramolecular complexprotein-containing complexcellorganellesupramolecular complexprotein-containing complexcellorganellesupramolecular complexprotein-containing complexcellorganellesupramolecular complexprotein-containing complexcellorganellesupramolecular complexprotein-containing complexcellorganellesupramolecular complexprotein-containing complexcellorganellesupramolecular complexprotein-containing complexcellcellorganelleorganellesupramolecular complexsupramolecular complexprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0002009 morphogenesis of an epithelium IEA
 biological_processGO:0003166 bundle of His development IEA
 biological_processGO:0003181 atrioventricular valve morphogenesis IEA
 biological_processGO:0003197 endocardial cushion development IEA
 biological_processGO:0003218 cardiac left ventricle formation IEP
 biological_processGO:0003229 ventricular cardiac muscle tissue development IEA
 biological_processGO:0003281 ventricular septum development IEP
 biological_processGO:0003283 atrial septum development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0032526 response to retinoic acid TAS
 biological_processGO:0035115 embryonic forelimb morphogenesis IMP
 biological_processGO:0035136 forelimb morphogenesis IEA
 biological_processGO:0035137 hindlimb morphogenesis TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048513 animal organ development ISS
 biological_processGO:0051891 positive regulation of cardioblast differentiation IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0060039 pericardium development IEA
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060173 limb development TAS
 biological_processGO:0060174 limb bud formation IMP
 biological_processGO:0060413 atrial septum morphogenesis IEA
 biological_processGO:0072513 positive regulation of secondary heart field cardioblast proliferation IEA
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0030274 LIM domain binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0051087 chaperone binding IPI
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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