ENSGALG00000008415


Gallus gallus
activityALS2proteinregulationexchangedomainguanyl-nucleotidefactorendosomegtpasekinaserabhomologyregulatorchromosomecondensationresponseorganizationvesiclerhoserinethreoninedbldhrccpleckstrinvpsmornmotifbeta-lactamase-inhibitorii

Features
Gene ID: ENSGALG00000008415
  
Biological name :ALS2
  
Synonyms : ALS2 / ALS2, alsin Rho guanine nucleotide exchange factor
  
Possible biological names infered from orthology : Alsin / Q920R0 / Q96Q42
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 11598549
Gene end: 11631574
  
Corresponding Affymetrix probe sets: Gga.11075.1.S1_at (Chicken Array)   Gga.13545.1.S1_at (Chicken Array)   GgaAffx.22565.2.S1_at (Chicken Array)   GgaAffx.22565.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013692
NCBI entrez gene - 424085     See in Manteia.
RefSeq - XM_004942618
RefSeq - XM_015289451
RefSeq - XM_015289452
RefSeq - XM_015289453
RefSeq - XM_015289454
RefSeq - XM_015289455
RefSeq - XM_421940
RefSeq - XM_004942617
swissprot - E1BX75
Ensembl - ENSGALG00000008415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 als2aENSDARG00000075111Danio rerio
 als2bENSDARG00000076924Danio rerio
 ALS2ENSG00000003393Homo sapiens
 Als2ENSMUSG00000026024Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ALS2CL / ALS2 C-terminal like / Q60I27*ENSGALG0000000543020
P0C881* / B2RC85* / RSPH10B* / RSPH10B2* / radial spoke head 10 homolog B* / radial spoke head 10 homolog B2* / radial spoke head 10 homolog B (Chlamydomonas)*ENSGALG000000453766
MORN3 / MORN repeat containing 3 / Q6PF18* / Q8C5T4* / Mus musculus MORN repeat containing 3 (Morn3), transcript variant 2, mRNA.*ENSGALG000000042474
RSPH1 / radial spoke head 1 homolog / Q8VIG3* / Q8WYR4* / radial spoke head 1 homolog (Chlamydomonas)*ENSGALG000000439764


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR001849  Pleckstrin homology domain
 IPR003123  VPS9 domain
 IPR003409  MORN motif
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
response to stresscellular metabolic processorganic substance metabolic processcellular component organizationlocomotory behaviormacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processprimary metabolic processanatomical structure developmentcellular developmental processregulation of biological qualityresponse to stresscellular metabolic processorganic substance metabolic processcellular component organizationlocomotory behaviormacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processprimary metabolic processanatomical structure developmentcellular developmental processregulation of biological qualityresponse to stresscellular metabolic processorganic substance metabolic processcellular component organizationlocomotory behaviormacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processprimary metabolic processanatomical structure developmentcellular developmental processregulation of biological qualityresponse to stresscellular metabolic processorganic substance metabolic processcellular component organizationlocomotory behaviormacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processprimary metabolic processanatomical structure developmentcellular developmental processregulation of biological qualityresponse to stresscellular metabolic processorganic substance metabolic processcellular component organizationlocomotory behaviormacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processprimary metabolic processanatomical structure developmentcellular developmental processregulation of biological qualityresponse to stresscellular metabolic processorganic substance metabolic processcellular component organizationlocomotory behaviormacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processprimary metabolic processanatomical structure developmentcellular developmental processregulation of biological qualityresponse to stresscellular metabolic processorganic substance metabolic processcellular component organizationlocomotory behaviormacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processprimary metabolic processanatomical structure developmentcellular developmental processregulation of biological qualityresponse to stresscellular metabolic processorganic substance metabolic processcellular component organizationlocomotory behaviormacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processprimary metabolic processanatomical structure developmentcellular developmental processregulation of biological qualityresponse to stresscellular metabolic processorganic substance metabolic processcellular component organizationlocomotory behaviormacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processprimary metabolic processanatomical structure developmentcellular developmental processregulation of biological qualityresponse to stresscellular metabolic processorganic substance metabolic processcellular component organizationlocomotory behaviormacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processprimary metabolic processanatomical structure developmentcellular developmental processregulation of biological qualityresponseresponse to stresscellularcellular metabolic processorganic organic substance metabolic processcellularcellular component organizationlocomotolocomotory behaviormacromolmacromolecule localizationestablisestablishment of localizationcellularcellular localizationcell comcell communicationcellularcellular response to stimulusregulatiregulation of molecular functionnitrogennitrogen compound metabolic processprimary primary metabolic processanatomicanatomical structure developmentcellularcellular developmental processregulatiregulation of biological quality
protein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingprotein bindingenzyme regulator activityenzyme regulator activity
cellorganellesynapseprotein-containing complexcellorganellesynapseprotein-containing complexcellorganellesynapseprotein-containing complexcellorganellesynapseprotein-containing complexcellorganellesynapseprotein-containing complexcellorganellesynapseprotein-containing complexcellorganellesynapseprotein-containing complexcellorganellesynapseprotein-containing complexcellorganellesynapseprotein-containing complexcellorganellesynapseprotein-containing complexcellcellorganelleorganellesynapsesynapseprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0001881 receptor recycling IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0007528 neuromuscular junction development IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0008104 protein localization IEA
 biological_processGO:0016050 vesicle organization IEA
 biological_processGO:0016197 endosomal transport IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0051036 regulation of endosome size IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043197 dendritic spine IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008415 ALS2 / ALS2, alsin Rho guanine nucleotide exchange factor / Alsin * / Q920R0* / Q96Q42*  / complex






 

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