ENSGALG00000008666


Gallus gallus

Features
Gene ID: ENSGALG00000008666
  
Biological name :CTLA4
  
Synonyms : CTLA4 / cytotoxic T-lymphocyte associated protein 4
  
Possible biological names infered from orthology : P16410
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 13461800
Gene end: 13465952
  
Corresponding Affymetrix probe sets: GgaAffx.5458.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000014096
NCBI entrez gene - 424106     See in Manteia.
RefSeq - NM_001040091
RefSeq Peptide - NP_001035180
swissprot - Q1XDY5
Ensembl - ENSGALG00000008666
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd28ENSDARG00000095070Danio rerio
 CTLA4ENSG00000163599Homo sapiens
 Ctla4ENSMUSG00000026011Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CD28 / P31043 / T-cell-specific surface glycoprotein CD28 homolog / P31041* / P10747* / CD28 molecule* / T-cell-specific surface glycoprotein CD28 *ENSGALG0000000866929


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008096  Cytotoxic T-lymphocyte antigen 4
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045590 negative regulation of regulatory T cell differentiation IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0098636 protein complex involved in cell adhesion IEA


Pathways (from Reactome)
Pathway description
CTLA4 inhibitory signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000008666 CTLA4 / cytotoxic T-lymphocyte associated protein 4 / P16410*  / complex
 ENSGALG00000014362 CD86 / CD86 molecule / P42081* / P42082* / T-lymphocyte activation antigen CD86 *  / complex / reaction






 

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