ENSGALG00000009929


Gallus gallus

Features
Gene ID: ENSGALG00000009929
  
Biological name :SOST
  
Synonyms : sclerostin / SOST
  
Possible biological names infered from orthology : Q9BQB4
  
Species: Gallus gallus
  
Chr. number: 27
Strand: 1
Band:
Gene start: 3504160
Gene end: 3508692
  
Corresponding Affymetrix probe sets: Gga.14173.1.S1_at (Chicken Array)   GgaAffx.6239.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052124
NCBI entrez gene - 429784     See in Manteia.
RefSeq - XM_004948551
RefSeq - XM_427339
swissprot - A0A1D5PH47
Ensembl - ENSGALG00000009929
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sostENSDARG00000061259Danio rerio
 SOSTENSG00000167941Homo sapiens
 SostENSMUSG00000001494Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6VYA3 / SOSTDC1 / Sclerostin domain-containing protein 1 / Q9CQN4* / Q6X4U4* / sclerostin domain containing 1*ENSGALG0000003683641
Q6X4U4* / Q9CQN4* / SOSTDC1* / sclerostin domain containing 1* / Sclerostin domain-containing protein 1 *ENSGALG0000003468538


Protein motifs (from Interpro)
Interpro ID Name
 IPR006207  Cystine knot, C-terminal
 IPR008835  Sclerostin/Sclerostin domain-containing protein 1
 IPR015665  Sclerostin
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0071374 cellular response to parathyroid hormone stimulus IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0008134 transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Negative regulation of TCF-dependent signaling by WNT ligand antagonists


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000031503 LRP6 / LDL receptor related protein 6 / O75581*  / complex / reaction






 

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