ENSMUSG00000001494


Mus musculus

Features
Gene ID: ENSMUSG00000001494
  
Biological name :Sost
  
Synonyms : sclerostin / Sost
  
Possible biological names infered from orthology : Q9BQB4
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 101962458
Gene end: 101967015
  
Corresponding Affymetrix probe sets: 10391508 (MoGene1.0st)   1421245_at (Mouse Genome 430 2.0 Array)   1450179_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001534
NCBI entrez gene - 74499     See in Manteia.
MGI - MGI:1921749
RefSeq - NM_024449
RefSeq Peptide - NP_077769
swissprot - B2RQA5
Ensembl - ENSMUSG00000001494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sostENSDARG00000061259Danio rerio
 SOSTENSGALG00000009929Gallus gallus
 SOSTENSG00000167941Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9CQN4 / Sostdc1 / Sclerostin domain-containing protein 1 / Q6X4U4* / sclerostin domain containing 1*ENSMUSG0000003616936


Protein motifs (from Interpro)
Interpro ID Name
 IPR008835  Sclerostin/Sclerostin domain-containing protein 1
 IPR015665  Sclerostin
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0071374 cellular response to parathyroid hormone stimulus IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0008134 transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Negative regulation of TCF-dependent signaling by WNT ligand antagonists


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm2.1Vlcg,Tg(Nanog-cre)#Vlcg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1.1Vlcg/Sirt1tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm2.1Vlcg,Tg(Nanog-cre)#Vlcg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0004149 increased bone strength "increased ability of bone to endure the application of force without yielding or breaking" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0004348 long femur "increased length of the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0010872 increased trabecular bone mass "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm2.1Vlcg,Tg(Nanog-cre)#Vlcg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0010932 increased trabecular bone connectivity density "increase in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
Show

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0010961 increased compact bone mass 
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0010964 increased compact bone volume 
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010967 increased compact bone area "increase in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0013640 increased bone stiffness "increase in material stiffness (N/mm) during elastic deformation" [MGI:jwhite]
Show

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0030442 decreased osteoblast apoptosis "reduction in the number of osteoblasts undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0030480 decreased osteocyte apoptosis "reduction in the number of osteocytes undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0030482 increased osteocyte number "greater than average number of mature osteoblasts that have become embedded in the bone matrix (osteoid) in small cavities called lacunae and that extend cytoplasmic (dendritic) processes away from the cell body toward other osteocytes and neighboring cells in small channels called canaliculi" [MGI:anna]
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Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / reaction / complex






 

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