ENSMUSG00000030201


Mus musculus

Features
Gene ID: ENSMUSG00000030201
  
Biological name :Lrp6
  
Synonyms : LDL receptor related protein 6 / Lrp6
  
Possible biological names infered from orthology : O75581
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G1
Gene start: 134446476
Gene end: 134566965
  
Corresponding Affymetrix probe sets: 10548701 (MoGene1.0st)   1428500_at (Mouse Genome 430 2.0 Array)   1451022_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032322
Ensembl peptide - ENSMUSP00000144733
NCBI entrez gene - 16974     See in Manteia.
MGI - MGI:1298218
RefSeq - NM_008514
RefSeq - XM_006505657
RefSeq Peptide - NP_032540
swissprot - A0A0R4J0A9
swissprot - A0A0N4SUL9
Ensembl - ENSMUSG00000030201
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrp6ENSDARG00000100143Danio rerio
 LRP6ENSGALG00000031503Gallus gallus
 LRP6ENSG00000070018Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrp5 / Q91VN0 / Low-density lipoprotein receptor-related protein 5 / O75197* / LDL receptor related protein 5*ENSMUSG0000002491369
Lrp4 / Q8VI56 / Low-density lipoprotein receptor-related protein 4 / O75096* / LDL receptor related protein 4*ENSMUSG0000002725337
Lrp2 / A2ARV4 / low density lipoprotein receptor-related protein 2 / P98164* / LDL receptor related protein 2*ENSMUSG0000002707034
Lrp1 / LDL receptor related protein 1 / Q07954*ENSMUSG0000004024933
Lrp1b / LDL receptor related protein 1B / Q9NZR2*ENSMUSG0000004925232
Gm19410ENSMUSG0000010937214
Lrp8 / Q924X6 / Low-density lipoprotein receptor-related protein 8 / Q14114* / LDL receptor related protein 8*ENSMUSG0000002861310
Vldlr / P98156 / very low density lipoprotein receptor / P98155*ENSMUSG000000249249
Ldlr / P35951 / Low-density lipoprotein receptor / P01130*ENSMUSG000000321939


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000742  EGF-like domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR017049  Low density lipoprotein receptor-related protein 5/6
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0014029 neural crest formation IEA
 biological_processGO:0014033 neural crest cell differentiation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0034392 negative regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0071397 cellular response to cholesterol IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:2000055 positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:1990851 Wnt-Frizzled-LRP5/6 complex IEA
 cellular_componentGO:1990909 Wnt signalosome IEA
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0019210 kinase inhibitor activity IEA
 molecular_functionGO:0019534 toxin transmembrane transporter activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity IEA
 molecular_functionGO:0071936 coreceptor activity involved in Wnt signaling pathway IEA


Pathways (from Reactome)
Pathway description
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

Allelic Composition: Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp6tm1.1Vari/Lrp6tm1.2Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Lrp5tm1Lex/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: KitW-39H/KitW-39H
Genetic Background: involves: BALB/cCrl * C3H/HeNCrl

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0000119 abnormal tooth eruption "anomalies in the passage of a tooth through the alveolar process and perforation of the gums" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0000128 growth retardation of molars "developmental delay of the growth of the molars" [J:17489]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

 MP:0000138 absent vertebrae "missing bony segments of the spinal column" [J:35802]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp6tm1.1Vari/Lrp6tm1.2Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fen1tm2.1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jag1tm1Grid/Jag1+,Notch2tm3.1Grid/Notch2+
Genetic Background: B6.129S1-Jag1tm1Grid Notch2tm3.1Grid

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Lrp6Gw/Lrp6+
Genetic Background: involves: 101/H * 129/Sv * BALB/c * C3H

Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * 129/Sv * BALB/c * C3H

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/c * C3H/HeH

 MP:0000436 abnormal head movements "anomalous motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Lrp5tm1Lex/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000555 absent carpal bone "missing the wrist bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54637]
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Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lrp5tm1Lex/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

 MP:0000566 synostosis "osseous union of two bones that are not normally connected" [J:13049]
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Allelic Composition: Lrp5tm1Lex/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

Allelic Composition: Lrp6Gw/Lrp6+
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Wnt3avt/Wnt3a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BR

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * DBA

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * C57BL/6

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

Allelic Composition: Lrp6Gw/Lrp6+
Genetic Background: involves: 101/H * BALB/c * C3H/HeH

Allelic Composition: Lrp6Gw/Lrp6+,Wnt3tm1Brd/Wnt3+
Genetic Background: involves: 101/H * 129S7/SvEvBrd * BALB/c * C3H

Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Lrp6Gw/Lrp6+
Genetic Background: involves: 101/H * 129/Sv * BALB/c * C3H

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/c * C3H/HeH

Allelic Composition: Lrp6skax26/Lrp6skax26
Genetic Background: involves: C57BL/6J

Allelic Composition: Lrp6skax26/Lrp6skax26
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lrp6skax26/Lrp6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6J * ICR

Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6J * ICR

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Lrp6Gw/Lrp6+
Genetic Background: involves: 101/H * BALB/c * C3H/HeH

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/c * C3H/HeH

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/c * C3H/HeH

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6m10Bei/Lrp6m10Bei
Genetic Background: involves: A/J * C57BL/6

 MP:0000963 fused dorsal root ganglia "loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023]
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Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6J * ICR

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Fen1tm2.1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0001677 absent apical ectodermal ridge "missing the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [J:54637]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

Allelic Composition: Lrp6rs/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp5tm1Lex/Lrp5+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il11ra1tm1Gos/Il11ra1tm1Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1

Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt71Ca/Krt71Ca-2H
Genetic Background: involves: 101/H

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0002632 vestigial tail "a trace or rudimentary tail structure; the degenerated remains of any tail structure" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0002861 abnormal tail bud morphology "anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6J * ICR

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6J * ICR

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Lrp6skax26/Lrp6skax26
Genetic Background: involves: C57BL/6J

Allelic Composition: Lrp6skax26/Lrp6skax26
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lrp6skax26/Lrp6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6m10Bei/Lrp6m10Bei
Genetic Background: involves: A/J * C57BL/6

Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0003074 absent metacarpal bones "missing the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0003126 abnormal vulva morphology "anomaly in the structure of the external genitalia of the female" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003445 sirenomelia "fusion of the posterior limbs often with partial or complete fusion of the autopods" [J:67375]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Lrp6m10Bei/Lrp6m10Bei
Genetic Background: involves: A/J * C57BL/6

 MP:0003795 abnormal bone structure 
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Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003800 monodactyly "having only one toe or digit on each extremity" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0003869 ectopic cartilage "positional abnormality of cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003975 increased circulating VLDL triglyceride level "higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fen1tm2.1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Lrp5tm1Lex/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1Bfc/Ctnnb1+,Lrp6Gw/Lrp6+
Genetic Background: either: (involves: 101/H * BALB/cCrl * C3H) or (involves: 101/H * BALB/cCrl * C3H * C57BL/6)

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6skax26/Lrp6skax26
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0004619 caudal vertebral fusion "the union of one or more caudal vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0004652 small caudal vertebrae "reduced size of the bony segments of the coccyx or tail; there are usually 27-30 present in rodents and only 3-5 fused vertebrae in human" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0004830 short incisors "reduced length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6J * ICR

 MP:0005029 abnormal amnion "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005223 abnormal anterior-posterior polarity of the somites "anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325]
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Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6J * ICR

 MP:0005297 spina bifida occulta "common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0005430 absent fibula "missing the lateral and shorter of the two bones of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86196]
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Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6J * ICR

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6J * ICR

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006400 decreased molar number "reduction in the number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0006402 small molars "reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008274 failure of bone ossification "failure to initiate or a block in the process of the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6m10Bei/Lrp6m10Bei
Genetic Background: involves: A/J * C57BL/6

 MP:0008832 hemivertebra "a congenital malformation of the spine in which only half of a vertebral body develops" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0009039 absent inferior colliculus "absence of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009127 increased brown fat cell number "increase in the number of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6J * ICR

 MP:0009199 abnormal external male genitalia morphology "any structural anomaly of the external masculine genital organs, including the penis and scrotum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6J * ICR

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0009908 protruding tongue "the tongue extends out beyond the oral cavity past the lips; may be due to paralysis, oral cavity size, tongue hypoplasia or dysfunction of the hypoglossal nerve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6tm1Arma/Lrp6tm1Arma
Genetic Background: C57BL/6-Lrp6tm1Arma

 MP:0010715 coloboma of the retina "congenital defect of the retina in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Genetic Background: involves: C57BL/6J * CD-1 * SJL

Allelic Composition: Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL

 MP:0010743 delayed suture closure "late onset of the fusion of the bones of the skull" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Lrp6tm1.1Vari/Lrp6tm1.2Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0011495 abnormal head shape "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0011496 abnormal head size "anomaly in the average size of the portion of the body containing the brain and organs of sight, hearing, taste, and smell" [MGI:csmith]
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Allelic Composition: Ctnnb1Bfc/Ctnnb1+,Lrp6Gw/Lrp6+
Genetic Background: either: (involves: 101/H * BALB/cCrl * C3H) or (involves: 101/H * BALB/cCrl * C3H * C57BL/6)

Allelic Composition: Ctnnb1Bfc/Ctnnb1+,Dkk1tm1Lmgd/Dkk1+,Lrp6Gw/Lrp6+
Genetic Background: either: (involves: 101/H * 129/Sv * BALB/cCrl * C3H) or (involves: 101/H * 129/Sv * BALB/cCrl * C3H * C57BL/6)

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0012062 small tail bud "decreased size or area of the primordial region of the embryo that arises to form the tail of the adult" [MGI:anna]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012078 abnormal tail ring morphology "any structural anomaly of the segmentally patterned skin ridges appearing on the tail of rodents" [MGI:csmith]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0012132 abnormal midbrain-hindbrain boundary morphology "any structural anomaly of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012139 increased forebrain size "greater than average size of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0012184 absent paraxial mesoderm "absence or loss of the mesoderm normally found at either side of the midline embryonic notochord that, on segmentation, forms the paired somites." [MGI:anna]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012547 spina bifida cystica "spinal bifida in which a hernial cyst containing meninges (meningocele), spinal cord (myelocele), or both (myelomeningocele) protrudes through a congenital cleft in the vertebral column; the protruding sac is encased in a layer of skin or a fine membrane that readily ruptures, causing leakage of cerebrospinal fluid and an increased risk of meningeal infection" [MGI:anna]
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Allelic Composition: Lrp6rs/Lrp6rs
Genetic Background: BALB/c

 MP:0013207 absent endoderm "absence of the innermost of the three primary germ layers of the embryo (the others being mesoderm and ectoderm) that is formed during gastrulation" [MGI:anna]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0013933 short Meckel s cartilage 
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0020523 decreased susceptibility to induced hypothermia "smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262]
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Allelic Composition: Tg(Atoh1-sb11)1Mtay/0,TgTn(sb-T2/Onc3)12740Njen/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6J * ICR

 MP:0030080 small lower incisors "reduced size of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0030083 long upper incisors "increased length or overgrowth of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0030279 thin neurocranium "decreased thickness of the bones of the skull enclosing the brain" [MGI:anna]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001494 Sost / sclerostin / Q9BQB4*  / reaction / complex
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / complex
 ENSMUSG00000009900 Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*  / complex
 ENSMUSG00000012282 Wnt8a / Q64527 / wingless-type MMTV integration site family, member 8A / Q9H1J5* / Wnt family member 8A*  / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex
 ENSMUSG00000024868 Dkk1 / O54908 / Dickkopf-related protein 1 / O94907* / dickkopf WNT signaling pathway inhibitor 1*  / complex / reaction
 ENSMUSG00000022997 Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*  / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / complex / reaction
 ENSMUSG00000034177 Rnf43 / Q5NCP0 / E3 ubiquitin-protein ligase RNF43 / Q68DV7* / ring finger protein 43*  / complex / reaction
 ENSMUSG00000044674 Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*  / complex
 ENSMUSG00000050288 Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*  / complex
 ENSMUSG00000040680 Q8K1S7 / Kremen2 / Kremen protein 2 / Q8NCW0* / kringle containing transmembrane protein 2*  / complex / reaction
 ENSMUSG00000024182 Axin1 / O15169*  / complex / reaction
 ENSMUSG00000041961 Znrf3 / Q5SSZ7 / zinc and ring finger 3 / Q9ULT6*  / complex / reaction
 ENSMUSG00000036961 Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*  / complex
 ENSMUSG00000027363 Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*  / reaction
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / complex
 ENSMUSG00000049791 Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*  / complex






 

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