ENSMUSG00000049252


Mus musculus

Features
Gene ID: ENSMUSG00000049252
  
Biological name :Lrp1b
  
Synonyms : LDL receptor related protein 1B / Lrp1b
  
Possible biological names infered from orthology : Q9NZR2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 40595246
Gene end: 42653624
  
Corresponding Affymetrix probe sets: 10482336 (MoGene1.0st)   1443131_at (Mouse Genome 430 2.0 Array)   1450211_at (Mouse Genome 430 2.0 Array)   1457235_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054275
Ensembl peptide - ENSMUSP00000145278
Ensembl peptide - ENSMUSP00000145066
Ensembl peptide - ENSMUSP00000145045
Ensembl peptide - ENSMUSP00000144957
Ensembl peptide - ENSMUSP00000139874
Ensembl peptide - ENSMUSP00000129192
Ensembl peptide - ENSMUSP00000117212
NCBI entrez gene - 94217     See in Manteia.
MGI - MGI:2151136
RefSeq - XM_017319348
RefSeq - NM_053011
RefSeq - XM_006498459
RefSeq - XM_006498460
RefSeq - XM_006498461
RefSeq - XM_006498462
RefSeq - XM_006498463
RefSeq Peptide - NP_443737
swissprot - E9Q202
swissprot - A0A0N4SVX0
swissprot - A0A0N4SVE4
swissprot - A0A0N4SVC8
swissprot - A0A0N4SV53
swissprot - A0A087WPQ4
swissprot - A2API5
swissprot - F6YDG9
Ensembl - ENSMUSG00000049252
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrp1baENSDARG00000004789Danio rerio
 lrp1bbENSDARG00000061517Danio rerio
 LRP1BENSGALG00000012407Gallus gallus
 LRP1BENSG00000168702Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrp1 / LDL receptor related protein 1 / Q07954*ENSMUSG0000004024959
Lrp2 / A2ARV4 / low density lipoprotein receptor-related protein 2 / P98164* / LDL receptor related protein 2*ENSMUSG0000002707034
Lrp4 / Q8VI56 / Low-density lipoprotein receptor-related protein 4 / O75096* / LDL receptor related protein 4*ENSMUSG0000002725314
Gm19410ENSMUSG0000010937212
Lrp5 / Q91VN0 / Low-density lipoprotein receptor-related protein 5 / O75197* / LDL receptor related protein 5*ENSMUSG0000002491311
Lrp6 / LDL receptor related protein 6 / O75581*ENSMUSG0000003020111
Vldlr / P98156 / very low density lipoprotein receptor / P98155*ENSMUSG000000249246
Lrp8 / Q924X6 / Low-density lipoprotein receptor-related protein 8 / Q14114* / LDL receptor related protein 8*ENSMUSG000000286136
Ldlr / P35951 / Low-density lipoprotein receptor / P01130*ENSMUSG000000321936


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR026823  Complement Clr-like EGF domain
 IPR032485  Domain of unknown function DUF5050
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

Allelic Composition: Lrp1btm1Her/Lrp1btm1Her
Genetic Background: 129S/SvEv-Lrp1btm1Her

Allelic Composition: Lrp1btm1Her/Lrp1btm1Her,Lrpap1tm1Her/Lrpap1tm1Her
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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