ENSMUSG00000034177


Mus musculus
membraneRnf43wntcellzincfingerproteincatabolicprocesssignalingpathwayubiquitinationregulationproliferationendoplasmicreticulumplasmaintegralcomponenttransferaseactivitybindingintestinalsmallring-typeringfyvephd-typeubiquitin-dependentreceptorstem

Features
Gene ID: ENSMUSG00000034177
  
Biological name :Rnf43
  
Synonyms : E3 ubiquitin-protein ligase RNF43 / Q5NCP0 / Rnf43
  
Possible biological names infered from orthology : Q68DV7 / ring finger protein 43
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 87662722
Gene end: 87735539
  
Corresponding Affymetrix probe sets: 10380116 (MoGene1.0st)   1427008_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090476
Ensembl peptide - ENSMUSP00000130685
Ensembl peptide - ENSMUSP00000112748
Ensembl peptide - ENSMUSP00000044241
NCBI entrez gene - 207742     See in Manteia.
MGI - MGI:2442609
RefSeq - XM_006532701
RefSeq - XM_011248844
RefSeq - NM_172448
RefSeq Peptide - NP_766036
swissprot - Q5NCP0
swissprot - E9PWJ5
swissprot - A3KMI3
Ensembl - ENSMUSG00000034177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RNF43ENSGALG00000001028Gallus gallus
 RNF43ENSG00000108375Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Znrf3 / Q5SSZ7 / zinc and ring finger 3 / Q9ULT6*ENSMUSG0000004196128
Q5SPX3 / Rnf215 / RING finger protein 215 / Q9Y6U7*ENSMUSG0000000358111
Rnf13 / O54965 / ring finger protein 13 / O43567*ENSMUSG0000003650311
Q91XF4 / Rnf167 / E3 ubiquitin-protein ligase RNF167 / Q9H6Y7* / ring finger protein 167*ENSMUSG0000004074610
Q8VEM1 / Rnf130 / ring finger protein 130 / Q86XS8*ENSMUSG000000203769
Q9D304 / Rnf128 / E3 ubiquitin-protein ligase RNF128 / Q8TEB7* / ring finger protein 128, E3 ubiquitin protein ligase*ENSMUSG000000314389
Q5DTZ6 / Rnf150 / RING finger protein 150 / Q9ULK6*ENSMUSG000000477479
Q3U2C5 / Rnf149 / E3 ubiquitin-protein ligase RNF149 / Q8NC42* / ring finger protein 149*ENSMUSG000000482349
Znrf4 / Q9DAH2 / zinc and ring finger 4 / Q8WWF5*ENSMUSG000000445268
Q14B02 / Rnf133 / E3 ubiquitin-protein ligase RNF133 / Q8WVZ7* / ring finger protein 133*ENSMUSG000000519568
G3X9R7 / Rnf148 / RING finger protein 148 / Q8N7C7*ENSMUSG000000781797


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
nitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusstem cell proliferationnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusstem cell proliferationnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusstem cell proliferationnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusstem cell proliferationnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusstem cell proliferationnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusstem cell proliferationnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusstem cell proliferationnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusstem cell proliferationnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusstem cell proliferationnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusstem cell proliferationnitrogen compoundnitrogen compound metabolic processcatabolic processcatabolic processcellular metabolicellular metabolic processprimary metabolicprimary metabolic processorganic substanceorganic substance metabolic processcell communicatiocell communicationcellular responsecellular response to stimulusstem cell prolifestem cell proliferation
catalytic activity, acting on a proteintransferase activityprotein bindingion bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcatalytic activity, acting on a procatalytic activity, acting on a proteintransferase activitytransferase activityprotein bindingprotein bindingion bindingion binding
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0038018 Wnt receptor catabolic process IEA
 biological_processGO:0072089 stem cell proliferation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
digestive/alimentary phenotypetumorigenesisendocrine/exocrine gland phenotypecellular phenotypedigestive/alimentary phenotypetumorigenesisendocrine/exocrine gland phenotypecellular phenotypedigestive/alimentary phenotypetumorigenesisendocrine/exocrine gland phenotypecellular phenotypedigestive/alimentary phenotypetumorigenesisendocrine/exocrine gland phenotypecellular phenotypedigestive/alimentary phenotypetumorigenesisendocrine/exocrine gland phenotypecellular phenotypedigestive/alimentary phenotypetumorigenesisendocrine/exocrine gland phenotypecellular phenotypedigestive/alimentary phenotypetumorigenesisendocrine/exocrine gland phenotypecellular phenotypedigestive/alimentary phenotypetumorigenesisendocrine/exocrine gland phenotypecellular phenotypedigestive/alimentary phenotypetumorigenesisendocrine/exocrine gland phenotypecellular phenotypedigestive/alimentary phenotypetumorigenesisendocrine/exocrine gland phenotypecellular phenotypedigestive/alimentary phenotypedigestive/alimentary phenotypetumorigenesistumorigenesisendocrine/exocrine gland phenotypeendocrine/exocrine gland phenotypecellular phenotypecellular phenotype
IDPhenotypeDefinition Genetic BG
 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0013485 increased Paneth cell number "greater than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
Show

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000009900 Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*  / complex / reaction
 ENSMUSG00000020140 Lgr5 / Q9Z1P4 / Leucine-rich repeat-containing G-protein coupled receptor 5 / O75473*  / complex / reaction
 ENSMUSG00000028871 Rspo1 / R-spondin 1 / Q2MKA7*  / complex / reaction
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex / reaction
 ENSMUSG00000032852 Rspo4 / Q8BJ73 / R-spondin-4 / Q2I0M5*  / complex / reaction
 ENSMUSG00000042793 Lgr6 / Q3UVD5 / Leucine-rich repeat-containing G-protein coupled receptor 6 / Q9HBX8*  / complex / reaction
 ENSMUSG00000050199 Lgr4 / A2ARI4 / Leucine-rich repeat-containing G-protein coupled receptor 4 / Q9BXB1*  / complex / reaction
 ENSMUSG00000049791 Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*  / complex / reaction
 ENSMUSG00000051920 Rspo2 / Q8BFU0 / Mus musculus R-spondin 2 (Rspo2), transcript variant 1, mRNA. / Q6UXX9* / R-spondin 2*  / complex / reaction
 ENSMUSG00000019880 Rspo3 / Q2TJ95 / R-spondin-3 / Q9BXY4*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr