ENSGALG00000011019


Gallus gallus
kinaseROR1proteindomainreceptortyrosine-proteinimmunoglobulinactivitymembranebindingkringlesubtypeimmunoglobulin-likesitefoldrorsignalingregulationnf-kappabfzdserine-threoninecatalyticactivekinase-likesuperfamilyi-setkringle-likeconservedfrizzledphosphorylationtransmembrane

Features
Gene ID: ENSGALG00000011019
  
Biological name :ROR1
  
Synonyms : receptor tyrosine kinase like orphan receptor 1 / ROR1
  
Possible biological names infered from orthology : Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973 / Q9Z139
  
Species: Gallus gallus
  
Chr. number: 8
Strand: 1
Band:
Gene start: 27993878
Gene end: 28122891
  
Corresponding Affymetrix probe sets: Gga.9476.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044620
Ensembl peptide - ENSGALP00000054152
Ensembl peptide - ENSGALP00000017932
NCBI entrez gene - 395179     See in Manteia.
RefSeq - XM_015290942
RefSeq - NM_204509
RefSeq - XM_015290940
RefSeq - XM_015290941
RefSeq Peptide - NP_989840
swissprot - A0A1D5PMR5
swissprot - F1NML5
swissprot - A0A1D5NW84
Ensembl - ENSGALG00000011019
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ror1ENSDARG00000015176Danio rerio
 ROR1ENSG00000185483Homo sapiens
 Ror1ENSMUSG00000035305Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ROR2 / receptor tyrosine kinase like orphan receptor 2 / Q01974* / Q9Z138*ENSGALG0000001520856
MUSK / muscle, skeletal receptor tyrosine protein kinase precursor / O15146* / Q61006* / muscle associated receptor tyrosine kinase* / Muscle, skeletal receptor tyrosine-protein kinase *ENSGALG0000001572822
NTRK2 / Q91987 / BDNF/NT-3 growth factors receptor / P15209* / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSGALG0000001259420
IGF1R / insulin-like growth factor 1 receptor precursor / P08069* / insulin like growth factor 1 receptor*ENSGALG0000004065120
NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *ENSGALG0000001901919
NTRK3 / Q91044 / NT-3 growth factor receptor / Q16288* / Q6VNS1* / neurotrophic receptor tyrosine kinase 3*ENSGALG0000004024119
INSR / insulin receptor / P06213* / P15208* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSGALG0000004075819
INSRR / insulin receptor related receptor / P14616* / Q9WTL4* / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain*ENSGALG0000001325318
LTK / leukocyte receptor tyrosine kinase / P08923* / P29376* / Leukocyte tyrosine kinase receptor *ENSGALG0000000861516
DDR1 / Q03146* / Q08345* / discoidin domain receptor tyrosine kinase 1* / Epithelial discoidin domain-containing receptor 1 *ENSGALG0000000861616
ROS1 / ROS proto-oncogene 1, receptor tyrosine kinase / P08922* / Q78DX7* / Proto-onco tyrosine-protein kinase ROS *ENSGALG0000001491316
DDR2 / discoidin domain receptor tyrosine kinase 2 / Q16832* / Q62371* / Discoidin domain-containing receptor 2 *ENSGALG0000003932215
PTK7 / inactive tyrosine-protein kinase 7 precursor / Q8BKG3* / Q13308* / Inactive tyrosine-protein kinase 7 * / protein tyrosine kinase 7 (inactive)*ENSGALG0000000860914
ALK* / P97793* / Q9UM73* / ALK receptor tyrosine kinase* / ALK tyrosine kinase receptor *ENSGALG0000000903412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR013806  Kringle-like fold
 IPR016247  Tyrosine-protein kinase, receptor ROR
 IPR018056  Kringle, conserved site
 IPR020067  Frizzled domain


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulussystem processanatomical structure developmentbiosynthetic processregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulussystem processanatomical structure developmentbiosynthetic processregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulussystem processanatomical structure developmentbiosynthetic processregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulussystem processanatomical structure developmentbiosynthetic processregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulussystem processanatomical structure developmentbiosynthetic processregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulussystem processanatomical structure developmentbiosynthetic processregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulussystem processanatomical structure developmentbiosynthetic processregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulussystem processanatomical structure developmentbiosynthetic processregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulussystem processanatomical structure developmentbiosynthetic processregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulussystem processanatomical structure developmentbiosynthetic processregulation of molecular functionnitrogen componitrogen compound metabolic processcellular metabcellular metabolic processprimary metaboprimary metabolic processorganic substaorganic substance metabolic processcell communicacell communicationcellular respocellular response to stimulussystem processsystem processanatomical stranatomical structure developmentbiosynthetic pbiosynthetic processregulation of regulation of molecular function
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingsignaling receptor activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingsignaling receptor activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingsignaling receptor activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingsignaling receptor activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingsignaling receptor activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingsignaling receptor activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingsignaling receptor activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingsignaling receptor activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingsignaling receptor activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingsignaling receptor activityorganic cyclicorganic cyclic compound bindingheterocyclic cheterocyclic compound bindingsmall moleculesmall molecule bindingcatalytic acticatalytic activity, acting on a proteintransferase actransferase activityion bindingion bindingcarbohydrate dcarbohydrate derivative bindingdrug bindingdrug bindingprotein bindinprotein bindingsignaling recesignaling receptor activity
cellmembraneprotein-containing complexsynapsecellmembraneprotein-containing complexsynapsecellmembraneprotein-containing complexsynapsecellmembraneprotein-containing complexsynapsecellmembraneprotein-containing complexsynapsecellmembraneprotein-containing complexsynapsecellmembraneprotein-containing complexsynapsecellmembraneprotein-containing complexsynapsecellmembraneprotein-containing complexsynapsecellmembraneprotein-containing complexsynapsecellcellmembranemembraneprotein-containing complexprotein-containing complexsynapsesynapse
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0043679 axon terminus IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity IEA


Pathways (from Reactome)
Pathway description
WNT5A-dependent internalization of FZD2, FZD5 and ROR2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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