ENSGALG00000011347


Gallus gallus

Features
Gene ID: ENSGALG00000011347
  
Biological name :IHH
  
Synonyms : IHH / Indian hedgehog protein Indian hedgehog protein N-product Indian hedgehog protein C-product / Q98938
  
Possible biological names infered from orthology : indian hedgehog / P97812 / Q14623
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 22427417
Gene end: 22435414
  
Corresponding Affymetrix probe sets: Gga.473.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018493
NCBI entrez gene - 395801     See in Manteia.
RefSeq - NM_204957
RefSeq Peptide - NP_990288
swissprot - H9KZS8
swissprot - Q98938
Ensembl - ENSGALG00000011347
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ihhaENSDARG00000058733Danio rerio
 ihhbENSDARG00000058815Danio rerio
 IHHENSG00000163501Homo sapiens
 IhhENSMUSG00000006538Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SHH / sonic hedgehog protein precursor / Q62226* / Q15465* / sonic hedgehog* / Sonic hedgehog protein Sonic hedgehog protein N-product*ENSGALG0000000637964
DHH / desert hedgehog / O43323* / Q61488* / Desert hedgehog protein Desert hedgehog protein N-product Desert hedgehog protein C-product*ENSGALG0000003170739


Protein motifs (from Interpro)
Interpro ID Name
 IPR000320  Hedgehog, N-terminal signalling domain
 IPR001657  Hedgehog protein
 IPR001767  Hedgehog protein, Hint domain
 IPR003586  Hint domain C-terminal
 IPR003587  Hint domain N-terminal
 IPR009045  Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
 IPR028992  Hedgehog/Intein (Hint) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001708 cell fate specification IEA
 biological_processGO:0001763 morphogenesis of a branching structure IEA
 biological_processGO:0001944 vasculature development IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IEA
 biological_processGO:0003382 epithelial cell morphogenesis IEA
 biological_processGO:0003406 retinal pigment epithelium development IEA
 biological_processGO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis IEA
 biological_processGO:0003420 regulation of growth plate cartilage chondrocyte proliferation IMP
 biological_processGO:0006029 proteoglycan metabolic process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007228 positive regulation of hh target transcription factor activity IMP
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009880 embryonic pattern specification IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010694 positive regulation of alkaline phosphatase activity IMP
 biological_processGO:0010770 positive regulation of cell morphogenesis involved in differentiation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030166 proteoglycan biosynthetic process IMP
 biological_processGO:0030704 vitelline membrane formation IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IMP
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0033085 negative regulation of T cell differentiation in thymus IEA
 biological_processGO:0033088 negative regulation of immature T cell proliferation in thymus IEA
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0035988 chondrocyte proliferation IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IEA
 biological_processGO:0046639 negative regulation of alpha-beta T cell differentiation IEA
 biological_processGO:0048074 negative regulation of eye pigmentation IEA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048557 embryonic digestive tract morphogenesis IEA
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048745 smooth muscle tissue development IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060220 camera-type eye photoreceptor cell fate commitment IEA
 biological_processGO:0060323 head morphogenesis IEA
 biological_processGO:0060591 chondroblast differentiation IMP
 biological_processGO:0061053 somite development IEA
 biological_processGO:0072498 embryonic skeletal joint development IEA
 biological_processGO:0090136 epithelial cell-cell adhesion IEA
 biological_processGO:1902733 regulation of growth plate cartilage chondrocyte differentiation IMP
 biological_processGO:1902738 regulation of chondrocyte differentiation involved in endochondral bone morphogenesis IMP
 biological_processGO:1903042 negative regulation of chondrocyte hypertrophy IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005113 patched binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog ligand biogenesis
Release of Hh-Np from the secreting cell
Ligand-receptor interactions
Activation of SMO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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