ENSGALG00000011434


Gallus gallus

Features
Gene ID: ENSGALG00000011434
  
Biological name :SLC11A1
  
Synonyms : natural resistance-associated macrophage protein 1 / SLC11A1
  
Possible biological names infered from orthology : P41251 / P49279 / solute carrier family 11 member 1 / solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 22674385
Gene end: 22678942
  
Corresponding Affymetrix probe sets: Gga.477.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018625
Ensembl peptide - ENSGALP00000048444
NCBI entrez gene - 395811     See in Manteia.
RefSeq - XM_015289785
RefSeq - XM_015289782
RefSeq - XM_015289783
RefSeq - XM_015289784
RefSeq - NM_204964
RefSeq Peptide - NP_990295
swissprot - A0A1I7Q416
swissprot - A0A1D5P6W3
Ensembl - ENSGALG00000011434
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P49279ENSG00000018280Homo sapiens
 P41251ENSMUSG00000026177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001046  NRAMP family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001818 negative regulation of cytokine production IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0002309 T cell proliferation involved in immune response IEA
 biological_processGO:0002369 T cell cytokine production IEA
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation IEA
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IEA
 biological_processGO:0006826 iron ion transport IEA
 biological_processGO:0006828 manganese ion transport IEA
 biological_processGO:0006876 cellular cadmium ion homeostasis IEA
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007035 vacuolar acidification IEA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0015707 nitrite transport IEA
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032623 interleukin-2 production IEA
 biological_processGO:0032632 interleukin-3 production IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042116 macrophage activation IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0042832 defense response to protozoan IEA
 biological_processGO:0045342 MHC class II biosynthetic process IEA
 biological_processGO:0045730 respiratory burst IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048002 antigen processing and presentation of peptide antigen IEA
 biological_processGO:0048255 mRNA stabilization IEA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0060586 multicellular organismal iron ion homeostasis IEA
 biological_processGO:0070574 cadmium ion transmembrane transport IEA
 biological_processGO:0070839 divalent metal ion export IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0070821 tertiary granule membrane IEA
 molecular_functionGO:0005384 manganese ion transmembrane transporter activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046873 metal ion transmembrane transporter activity IEA
 molecular_functionGO:0046915 transition metal ion transmembrane transporter activity IEA
 molecular_functionGO:0051139 metal ion:proton antiporter activity IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Metal ion SLC transporters
Neutrophil degranulation
Ion influx/efflux at host-pathogen interface


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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