ENSMUSG00000026177


Mus musculus

Features
Gene ID: ENSMUSG00000026177
  
Biological name :Slc11a1
  
Synonyms : P41251 / Slc11a1 / solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
  
Possible biological names infered from orthology : P49279 / solute carrier family 11 member 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C3
Gene start: 74375195
Gene end: 74386062
  
Corresponding Affymetrix probe sets: 10347335 (MoGene1.0st)   1420361_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027368
Ensembl peptide - ENSMUSP00000139455
NCBI entrez gene - 18173     See in Manteia.
MGI - MGI:1345275
RefSeq - XM_006495774
RefSeq - NM_013612
RefSeq - XM_006495773
RefSeq Peptide - NP_038640
swissprot - P41251
swissprot - A0A087WNR0
Ensembl - ENSMUSG00000026177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC11A1ENSGALG00000011434Gallus gallus
 P49279ENSG00000018280Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P49282 / Slc11a2 / solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 / P49281* / solute carrier family 11 member 2*ENSMUSG0000002303062


Protein motifs (from Interpro)
Interpro ID Name
 IPR001046  NRAMP family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade ISO
 biological_processGO:0001818 negative regulation of cytokine production IMP
 biological_processGO:0001819 positive regulation of cytokine production IMP
 biological_processGO:0002309 T cell proliferation involved in immune response IMP
 biological_processGO:0002369 T cell cytokine production IMP
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation IMP
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006826 iron ion transport IEA
 biological_processGO:0006828 manganese ion transport IMP
 biological_processGO:0006876 cellular cadmium ion homeostasis IEA
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0006909 phagocytosis IMP
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007035 vacuolar acidification IMP
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0015707 nitrite transport IDA
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0032147 activation of protein kinase activity IMP
 biological_processGO:0032496 response to lipopolysaccharide ISO
 biological_processGO:0032623 interleukin-2 production IMP
 biological_processGO:0032632 interleukin-3 production IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0034341 response to interferon-gamma IDA
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0042116 macrophage activation IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0045342 MHC class II biosynthetic process IMP
 biological_processGO:0045730 respiratory burst IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048002 antigen processing and presentation of peptide antigen IMP
 biological_processGO:0048255 mRNA stabilization IMP
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0055072 iron ion homeostasis IMP
 biological_processGO:0060586 multicellular organismal iron ion homeostasis IMP
 biological_processGO:0070574 cadmium ion transmembrane transport IEA
 biological_processGO:0070839 divalent metal ion export IDA
 biological_processGO:0071421 manganese ion transmembrane transport IEA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005770 late endosome IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0070821 tertiary granule membrane IEA
 molecular_functionGO:0005384 manganese ion transmembrane transporter activity IMP
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046873 metal ion transmembrane transporter activity IEA
 molecular_functionGO:0046915 transition metal ion transmembrane transporter activity IEA
 molecular_functionGO:0051139 metal ion:proton antiporter activity IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Metal ion SLC transporters
Neutrophil degranulation
Ion influx/efflux at host-pathogen interface


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: involves: BXH2/TyJ * C3H/HeJ

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: involves: A/J * BXH2/TyJ

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: l1Rk3/Mlphln
Genetic Background: involves: C57L/J

Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: 129/Sv

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Slc11a1tm1Mcg/Slc11a1s
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: C57BL/6J

Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: BALB/c

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1s
Genetic Background: involves: BXH2/TyJ * C57BL/6J

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: involves: BXH2/TyJ * C57BL/6J

Allelic Composition: Irf8myls/Irf8myls,Slc11a1s/Slc11a1s
Genetic Background: involves: BALB/cJ * BXH2/TyJ

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1s
Genetic Background: involves: BALB/cJ * BXH2/TyJ

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: involves: BALB/cJ * BXH2/TyJ

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: involves: BXH2/TyJ * C3H/HeJ

Allelic Composition: Nlrc4tm1Gln/Nlrc4tm1Gln,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Nlrc4tm1Gln

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1s/Slc11a1s
Genetic Background: B6.129S2-Casp1tm1Flv

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1r/Slc11a1r
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Nlrp3tm1Flv

Allelic Composition: Pycardtm1Flv/Pycardtm1Flv,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Pycardtm1Flv

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Slc11a1s/Slc11a1s
Genetic Background: B6.129S2-Casp1tm1Sesh Casp4del

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Slc11a1r/Slc11a1s
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Slc11a1s/Slc11a1s
Genetic Background: B6.129S2-Casp1tm1Sesh Casp4del

 MP:0005481 chronic myelocytic leukemia "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: involves: A/J * BXH2/TyJ

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1s/Slc11a1s
Genetic Background: B6.129S2-Casp1tm1Flv

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1s/Slc11a1s
Genetic Background: B6.129S2-Casp1tm1Flv

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1r/Slc11a1r
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Nlrp3tm1Flv

 MP:0020186 altered susceptibility to bacterial infection "a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [GOC:NV]
Show

Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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