Manteia

ENSGALG00000011468

Gallus gallus

Features

Gene ID:	ENSGALG00000011468

Biological name :	IGFBP5

Synonyms :	IGFBP5 / insulin like growth factor binding protein 5

Possible biological names infered from orthology :	P24593 / Q07079

Species:	Gallus gallus

Chr. number:	7
Strand:	1
Band:
Gene start:	23359550
Gene end:	23376226

Corresponding Affymetrix probe sets:	Gga.9364.1.S1_at (Chicken Array)

Cross references:	Ensembl peptide - ENSGALP00000037370 NCBI entrez gene - 424220 See in Manteia. RefSeq - XM_422069 swissprot - F1ND88 Ensembl - ENSGALG00000011468

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
igfbp5a	ENSDARG00000039264	Danio rerio
igfbp5b	ENSDARG00000025348	Danio rerio
IGFBP5	ENSG00000115461	Homo sapiens
Igfbp5	ENSMUSG00000026185	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
IGFBP3 / insulin like growth factor binding protein 3 / P17936* / P47878*	ENSGALG00000037940	42
IGFBP4 / insulin-like growth factor-binding protein 4 precursor / P22692* / P47879* / insulin like growth factor binding protein 4*	ENSGALG00000040672	35
IGFBP1 / insulin-like growth factor-binding protein 1 precursor / P08833* / P47876* / insulin like growth factor binding protein 1*	ENSGALG00000043493	32
IGFBP2 / insulin-like growth factor-binding protein 2 precursor / P18065* / P47877* / insulin like growth factor binding protein 2*	ENSGALG00000011469	29

Protein motifs (from Interpro)

Interpro ID	Name
IPR000716	Thyroglobulin type-1
IPR000867	Insulin-like growth factor-binding protein, IGFBP
IPR009030	Growth factor receptor cysteine-rich domain superfamily
IPR009168	Insulin-like growth factor binding protein
IPR012213	Insulin-like growth factor binding protein 5
IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
IPR022321	Insulin-like growth factor-binding protein family 1-6, chordata

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001558	regulation of cell growth	IEA
biological_process	GO:0001649	osteoblast differentiation	IEA
biological_process	GO:0006006	glucose metabolic process	IEA
biological_process	GO:0007565	female pregnancy	IEA
biological_process	GO:0010906	regulation of glucose metabolic process	IEA
biological_process	GO:0014912	negative regulation of smooth muscle cell migration	IEA
biological_process	GO:0017148	negative regulation of translation	IEA
biological_process	GO:0030336	negative regulation of cell migration	IEA
biological_process	GO:0031069	hair follicle morphogenesis	IEA
biological_process	GO:0040008	regulation of growth	IEA
biological_process	GO:0042593	glucose homeostasis	IEA
biological_process	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	IBA
biological_process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	IEA
biological_process	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	IEA
biological_process	GO:0044342	type B pancreatic cell proliferation	IEA
biological_process	GO:0045668	negative regulation of osteoblast differentiation	IEA
biological_process	GO:0045926	negative regulation of growth	IEA
biological_process	GO:0048286	lung alveolus development	IEA
biological_process	GO:0048662	negative regulation of smooth muscle cell proliferation	IEA
biological_process	GO:0051146	striated muscle cell differentiation	IEA
biological_process	GO:0051897	positive regulation of protein kinase B signaling	IEA
biological_process	GO:0060056	mammary gland involution	IEA
biological_process	GO:0071320	cellular response to cAMP	IEA
biological_process	GO:0071407	cellular response to organic cyclic compound	IEA
biological_process	GO:1901862	negative regulation of muscle tissue development	IEA
biological_process	GO:1904205	negative regulation of skeletal muscle hypertrophy	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IBA
cellular_component	GO:0042567	insulin-like growth factor ternary complex	IEA
molecular_function	GO:0001968	fibronectin binding	IEA
molecular_function	GO:0005520	insulin-like growth factor binding	IEA
molecular_function	GO:0031994	insulin-like growth factor I binding	IEA
molecular_function	GO:0031995	insulin-like growth factor II binding	IBA

Pathways (from Reactome)

Pathway description

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Post-translational protein phosphorylation

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSGALG00000012755	IGF-I / P18254 / Insulin-like growth factor I / IGF1* / P05017* / P05019* / insulin like growth factor 1*	/ complex / reaction
ENSGALG00000035282	IGF2 / P33717 / Insulin-like growth factor II / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr