ENSGALG00000011620


Gallus gallus

Features
Gene ID: ENSGALG00000011620
  
Biological name :AKT1
  
Synonyms : AKT1 / RAC-alpha serine/threonine-protein kinase
  
Possible biological names infered from orthology : AKT serine/threonine kinase 1 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749 / P31750
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 51675984
Gene end: 51745443
  
Corresponding Affymetrix probe sets: Gga.3875.1.S1_at (Chicken Array)   Gga.3875.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000036651
NCBI entrez gene - 395928     See in Manteia.
RefSeq - NM_205055
RefSeq Peptide - NP_990386
swissprot - F1NMS0
Ensembl - ENSGALG00000011620
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akt1ENSDARG00000099657Danio rerio
 AKT1ENSG00000142208Homo sapiens
 Akt1ENSMUSG00000001729Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AKT3 / AKT serine/threonine kinase 3 / Q9WUA6* / Q9Y243* / RAC-gamma serine/threonine-protein kinase *ENSGALG0000003408184
PRKCD / protein kinase C delta type / P28867* / Q05655* / protein kinase C delta*ENSGALG0000000201638
PRKCE / protein kinase C epsilon / P16054* / Q02156*ENSGALG0000001000038
PRKCH / protein kinase C eta / P23298* / P24723*ENSGALG0000001188938
PRKCA / protein kinase C alpha / P17252*ENSGALG0000002595038
PRKCB / protein kinase C beta / P05771* / P68404*ENSGALG0000003794338
PRKCQ / protein kinase C theta / Q02111* / Q04759*ENSGALG0000003497036
SGK3 / serum/glucocorticoid regulated kinase family member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSGALG0000004357036
PRKCI / protein kinase C iota type / P41743* / Q62074* / protein kinase C iota*ENSGALG0000000936435
SGK1 / Q6U1I9 / Serine/threonine-protein kinase Sgk1 / Q9WVC6* / O00141* / serum/glucocorticoid regulated kinase 1*ENSGALG0000001397135
PRKCZ / protein kinase C zeta / Q02956* / Q05513*ENSGALG0000000127034
SGK2 / SGK2, serine/threonine kinase 2 / Q9HBY8* / Q9QZS5* / Serine/threonine-protein kinase Sgk2 *ENSGALG0000000353733


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001893 maternal placenta development IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0005979 regulation of glycogen biosynthetic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006924 activation-induced cell death of T cells IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0008637 apoptotic mitochondrial changes IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010748 negative regulation of plasma membrane long-chain fatty acid transport IEA
 biological_processGO:0010763 positive regulation of fibroblast migration IEA
 biological_processGO:0010765 positive regulation of sodium ion transport IEA
 biological_processGO:0010907 positive regulation of glucose metabolic process IEA
 biological_processGO:0010918 positive regulation of mitochondrial membrane potential IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031641 regulation of myelination IEA
 biological_processGO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0031999 negative regulation of fatty acid beta-oxidation IEA
 biological_processGO:0032079 positive regulation of endodeoxyribonuclease activity IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032287 peripheral nervous system myelin maintenance IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034405 response to fluid shear stress IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035655 interleukin-18-mediated signaling pathway IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0036294 cellular response to decreased oxygen levels IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IEA
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0046622 positive regulation of organ growth IEA
 biological_processGO:0046889 positive regulation of lipid biosynthetic process IEA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0060416 response to growth hormone ISS
 biological_processGO:0060709 glycogen cell differentiation involved in embryonic placenta development IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0070141 response to UV-A IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IEA
 biological_processGO:0072655 establishment of protein localization to mitochondrion IEA
 biological_processGO:0072656 maintenance of protein location in mitochondrion IEA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
 biological_processGO:0097194 execution phase of apoptosis IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1901653 cellular response to peptide IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1903721 positive regulation of I-kappaB phosphorylation IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990418 response to insulin-like growth factor stimulus ISS
 biological_processGO:2000010 positive regulation of protein localization to cell surface IEA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030235 nitric-oxide synthase regulator activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
mTOR signalling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
eNOS activation
AKT-mediated inactivation of FOXO1A
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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