ENSDARG00000099657


Danio rerio

Features
Gene ID: ENSDARG00000099657
  
Biological name :akt1
  
Synonyms : akt1 / v-akt murine thymoma viral oncogene homolog 1
  
Possible biological names infered from orthology : AKT serine/threonine kinase 1 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749 / P31750
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 1514711
Gene end: 1533170
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000131294
swissprot - A0A0G2KG61
ZFIN ID - ZDB-GENE-130730-1
Ensembl - ENSDARG00000099657
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AKT1ENSGALG00000011620Gallus gallus
 AKT1ENSG00000142208Homo sapiens
 Akt1ENSMUSG00000001729Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
akt3a / v-akt murine thymoma viral oncogene homolog 3a / AKT3* / Q9WUA6* / Q9Y243* / AKT serine/threonine kinase 3* / RAC-gamma serine/threonine-protein kinase *ENSDARG0000010481086
akt3b / v-akt murine thymoma viral oncogene homolog 3bENSDARG0000008720585
akt2 / v-akt murine thymoma viral oncogene homolog 2 / P31751* / Q60823* / AKT serine/threonine kinase 2* / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA.*ENSDARG0000001121982
akt2l / v-akt murine thymoma viral oncogene homolog 2, like / AKT2* / P31751* / AKT serine/threonine kinase 2*ENSDARG0000010361277
sgk1 / Q7ZTW4 / serum/glucocorticoid regulated kinase 1 / Q9WVC6* / O00141* / Serine/threonine-protein kinase Sgk1 *ENSDARG0000002552248
si:ch211-195b13.1ENSDARG0000001662347
prkcz / protein kinase C, zeta / Q02956* / Q05513*ENSDARG0000004333247
sgk3 / serum/glucocorticoid regulated kinase family, member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSDARG0000006246046
sgk2a / serum/glucocorticoid regulated kinase 2a / SGK2* / Q9QZS5* / Q9HBY8* / SGK2, serine/threonine kinase 2* / Serine/threonine-protein kinase Sgk2 *ENSDARG0000006337046
prkci / Q90XF2 / protein kinase C, iota / P41743* / Q62074*ENSDARG0000002122545
prkcha / protein kinase C, eta, a / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000001838244
prkcea / protein kinase C, epsilon a / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000000300843
sgk2b / serum/glucocorticoid regulated kinase 2bENSDARG0000000659843
prkchb / protein kinase C, eta, b / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000004324343
prkceb / protein kinase C, epsilon b / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000006992843
prkcdb / protein kinase C, delta b / PRKCD* / Q05655* / protein kinase C delta*ENSDARG0000007065142
prkcg / protein kinase C, gamma / P05129* / P63318*ENSDARG0000000456141
prkcq / protein kinase C, theta / Q02111* / Q04759*ENSDARG0000003417341
prkcbb / Q7SY24 / protein kinase C, beta b / PRKCB* / P05771* / protein kinase C beta*ENSDARG0000002225440
PRKCA / si:ch73-374l24.1 / si:ch1073-370j18.1 / P17252* / protein kinase C alpha*ENSDARG0000009984140


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 cellular_componentGO:0005622 intracellular IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
mTOR signalling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
eNOS activation
AKT-mediated inactivation of FOXO1A
Integrin alphaIIb beta3 signaling
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
RAB GEFs exchange GTP for GDP on RABs
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain malformed , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0001115 trunk trunk bent , abnormal
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 ZFA:0009011 neuroblast neuroblast decreased amount , abnormal
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 ZFA:0009248 neuron neuron apoptotic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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