ENSGALG00000012179


Gallus gallus
regulationSOCS4proteindomainsocsactivitykinaseepidermalgrowthreceptorsignalingpathwayintracellularshboxsuppressorcytokinesignallingfactor-activatedubiquitinationcytokine-mediatedproteasomalubiquitin-dependentcatabolicprocesssignaltransductionfactorjak-statcascadecytoplasm

Features
Gene ID: ENSGALG00000012179
  
Biological name :SOCS4
  
Synonyms : SOCS4 / suppressor of cytokine signaling 4
  
Possible biological names infered from orthology : Q8WXH5 / Q91ZA6
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 56427943
Gene end: 56436093
  
Corresponding Affymetrix probe sets: Gga.16094.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000064656
Ensembl peptide - ENSGALP00000019859
NCBI entrez gene - 423557     See in Manteia.
RefSeq - XM_015287524
RefSeq - NM_001199108
RefSeq Peptide - NP_001186037
swissprot - B2WUP0
swissprot - F1NEM3
Ensembl - ENSGALG00000012179
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SOCS4ENSG00000180008Homo sapiens
 Socs4ENSMUSG00000048379Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOCS5 / suppressor of cytokine signaling 5 / O54928* / O75159*ENSGALG0000001001652
SOCS6 / suppressor of cytokine signaling 6 / O14544* / Q9JLY0*ENSGALG0000001373122
SOCS7* / O14512* / Q8VHQ2* / suppressor of cytokine signaling 7*ENSGALG0000004065815
CISH / cytokine-inducible SH2-containing protein / Q62225* / Q9NSE2*ENSGALG0000000226013
SOCS1 / suppressor of cytokine signaling 1 / O15524* / O35716*ENSGALG0000000715811
SOCS2 / suppressor of cytokine signaling 2 / O14508* / O35717*ENSGALG0000001129511
SOCS3 / suppressor of cytokine signaling 3 / O14543* / O35718*ENSGALG0000002778611
SOCS1L / uncharacterized protein LOC417978 ENSGALG000000231938


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR022252  SOCS4/SOCS5 domain
 IPR028416  Suppressor of cytokine signalling 4


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationcellular response to stimulusresponse to chemicalcatabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationcellular response to stimulusresponse to chemicalcatabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationcellular response to stimulusresponse to chemicalcatabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationcellular response to stimulusresponse to chemicalcatabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationcellular response to stimulusresponse to chemicalcatabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationcellular response to stimulusresponse to chemicalcatabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationcellular response to stimulusresponse to chemicalcatabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationcellular response to stimulusresponse to chemicalcatabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationcellular response to stimulusresponse to chemicalcatabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationcellular response to stimulusresponse to chemicalcatabolic processnitrogen compounitrogen compound metabolic processcellular metabocellular metabolic processprimary metabolprimary metabolic processregulation of mregulation of molecular functionorganic substanorganic substance metabolic processcell communicatcell communicationcellular responcellular response to stimulusresponse to cheresponse to chemicalcatabolic procecatabolic process
enzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activityenzyme regulator activity
cellcellcellcellcellcellcellcellcellcellcellcell
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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