ENSGALG00000013235


Gallus gallus

Features
Gene ID: ENSGALG00000013235
  
Biological name :PDK1
  
Synonyms : PDK1 / pyruvate dehydrogenase kinase 1
  
Possible biological names infered from orthology : [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial / Q15118 / Q8BFP9
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 17783868
Gene end: 17793750
  
Corresponding Affymetrix probe sets: GgaAffx.11753.1.S1_at (Chicken Array)   GgaAffx.8426.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000021580
NCBI entrez gene - 425972     See in Manteia.
RefSeq - NM_001031352
RefSeq Peptide - NP_001026523
swissprot - F1NLP2
Ensembl - ENSGALG00000013235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdk1ENSDARG00000013128Danio rerio
 PDK1ENSG00000152256Homo sapiens
 Pdk1ENSMUSG00000006494Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDK3 / pyruvate dehydrogenase kinase 3 / Q15120* / Q922H2* / pyruvate dehydrogenase kinase, isoenzyme 3*ENSGALG0000001632369
PDK4 / pyruvate dehydrogenase kinase 4 / O70571* / Q16654* / pyruvate dehydrogenase kinase, isoenzyme 4*ENSGALG0000000970064
PDK2* / Q15119* / Q9JK42* / pyruvate dehydrogenase kinase 2* / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial *ENSGALG0000004584662


Protein motifs (from Interpro)
Interpro ID Name
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR005467  Histidine kinase domain
 IPR018955  Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA
 biological_processGO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate IEA
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0097411 hypoxia-inducible factor-1alpha signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005967 mitochondrial pyruvate dehydrogenase complex IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007904 DLAT / dihydrolipoamide S-acetyltransferase / P10515* / Q8BMF4* / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial *  / reaction
 ENSGALG00000007931 DLD / dihydrolipoamide dehydrogenase / O08749* / P09622* / Dihydrolipoyl dehydrogenase, mitochondrial *  / reaction
 ENSGALG00000016430 PDHA1 / PDHA2* / P35486* / P35487* / P08559* / P29803* / pyruvate dehydrogenase E1 alpha 1* / pyruvate dehydrogenase E1 alpha 1 subunit* / pyruvate dehydrogenase E1 alpha 2 subunit* / Pyruv...  / reaction
 ENSGALG00000029576 PDHB / pyruvate dehydrogenase E1 component subunit beta, mitochondrial / P11177* / Q9D051* / pyruvate dehydrogenase E1 beta subunit*  / reaction






 

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