ENSGALG00000014956


Gallus gallus

Features
Gene ID: ENSGALG00000014956
  
Biological name :POLK
  
Synonyms : DNA polymerase kappa / POLK
  
Possible biological names infered from orthology : polymerase (DNA directed), kappa / Q9QUG2 / Q9UBT6
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 23872296
Gene end: 23901621
  
Corresponding Affymetrix probe sets: Gga.16231.1.S1_at (Chicken Array)   Gga.3291.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000024077
NCBI entrez gene - 374003     See in Manteia.
RefSeq - XM_015277223
RefSeq - NM_204183
RefSeq - XM_015277221
RefSeq - XM_015277222
RefSeq - XM_015277214
RefSeq - XM_015277216
RefSeq - XM_015277217
RefSeq - XM_015277218
RefSeq - XM_015277219
RefSeq - XM_015277220
RefSeq Peptide - NP_989514
swissprot - Q8AWW1
Ensembl - ENSGALG00000014956
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polkENSDARG00000059963Danio rerio
 POLKENSG00000122008Homo sapiens
 PolkENSMUSG00000021668Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
REV1 / DNA repair protein REV1 / Q920Q2* / Q9UBZ9* / REV1, DNA directed polymerase*ENSGALG0000001676618
POLH / DNA polymerase eta / Q9JJN0* / Q9Y253*ENSGALG0000001031714


Protein motifs (from Interpro)
Interpro ID Name
 IPR001126  UmuC domain
 IPR006642  Zinc finger, Rad18-type putative
 IPR017061  DNA polymerase eta/kappa/iota/IV
 IPR017961  DNA polymerase, Y-family, little finger domain
 IPR022880  DNA polymerase IV
 IPR024728  DNA polymerase type-Y, HhH motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0042276 error-prone translesion synthesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0090734 site of DNA damage IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0034061 DNA polymerase activity TAS


Pathways (from Reactome)
Pathway description
Translesion synthesis by Pol kappa
Translesion synthesis by POLK
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / complex / reaction
 ENSGALG00000003144 TRIM25 / Gallus gallus tripartite motif containing 25 (TRIM25), mRNA. / Q14258* / Q61510* / tripartite motif containing 25* / E3 ubiquitin/ISG15 ligase TRIM25 *  / complex
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / complex / reaction
 ENSGALG00000004640 MAD2L2 / Q4KWZ6 / Mitotic spindle assembly checkpoint protein MAD2B / Q9D752* / Q9UI95* / mitotic arrest deficient 2 like 2*  / complex / reaction
 ENSGALG00000014956 POLK / DNA polymerase kappa / Q9QUG2* / Q9UBT6* / polymerase (DNA directed), kappa*  / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / complex / reaction
 ENSGALG00000016766 REV1 / DNA repair protein REV1 / Q920Q2* / Q9UBZ9* / REV1, DNA directed polymerase*  / complex / reaction
 ENSGALG00000015033 REV3L / REV3 like, DNA directed polymerase zeta catalytic subunit / O60673* / Q61493* / DNA polymerase zeta catalytic subunit *  / complex / reaction
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction






 

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