ENSGALG00000017235


Gallus gallus

Features
Gene ID: ENSGALG00000017235
  
Biological name :NOX4
  
Synonyms : NADPH oxidase 4 / NOX4
  
Possible biological names infered from orthology : Q9JHI8 / Q9NPH5
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 187793324
Gene end: 187896831
  
Corresponding Affymetrix probe sets: Gga.10312.1.S1_at (Chicken Array)   Gga.11798.1.S1_s_at (Chicken Array)   GgaAffx.25209.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048739
Ensembl peptide - ENSGALP00000027810
NCBI entrez gene - 419012     See in Manteia.
RefSeq - XM_015280045
RefSeq - NM_001101829
RefSeq - XM_015280040
RefSeq Peptide - NP_001095299
swissprot - F1NWG5
swissprot - A0A1D5P7P8
Ensembl - ENSGALG00000017235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOX4ENSDARG00000114937Danio rerio
 NOX4ENSG00000086991Homo sapiens
 Nox4ENSMUSG00000030562Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYBB / cytochrome b-245 beta chain / P04839* / Q61093* / Cytochrome b-245 heavy chain *ENSGALG0000001626136
NOX1 / NADPH oxidase 1 / Q8CIZ9* / Q9Y5S8*ENSGALG0000000670733
NOX3 / NADPH oxidase 3 / Q672J9* / Q9HBY0*ENSGALG0000001365933
DUOX1* / DUOX2* / Q9NRD8* / Q9NRD9* / dual oxidase 1* / dual oxidase 2*ENSGALG0000004151028
NOX5 / NADPH oxidase 5 / Q96PH1*ENSGALG0000000806322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000778  Cytochrome b245, heavy chain
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010467 gene expression IEA
 biological_processGO:0042554 superoxide anion generation IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0050667 homocysteine metabolic process IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0072341 modified amino acid binding IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000016261 CYBB / cytochrome b-245 beta chain / P04839* / Q61093* / Cytochrome b-245 heavy chain *  / complex
 ENSGALG00000029367 CYBA / cytochrome b-245 alpha chain / P13498* / Q61462* / Cytochrome b-245 light chain *  / complex






 

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