ENSMUSG00000030562


Mus musculus

Features
Gene ID: ENSMUSG00000030562
  
Biological name :Nox4
  
Synonyms : NADPH oxidase 4 / Nox4 / Q9JHI8
  
Possible biological names infered from orthology : Q9NPH5
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D3
Gene start: 87246096
Gene end: 87398710
  
Corresponding Affymetrix probe sets: 10554752 (MoGene1.0st)   1419161_a_at (Mouse Genome 430 2.0 Array)   1451827_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138274
Ensembl peptide - ENSMUSP00000138143
Ensembl peptide - ENSMUSP00000138336
Ensembl peptide - ENSMUSP00000032781
Ensembl peptide - ENSMUSP00000070039
Ensembl peptide - ENSMUSP00000119365
NCBI entrez gene - 50490     See in Manteia.
MGI - MGI:1354184
RefSeq - XM_017322347
RefSeq - NM_001285833
RefSeq - NM_001285835
RefSeq - NM_015760
RefSeq - XM_006508010
RefSeq - XM_006508012
RefSeq - XM_011241854
RefSeq Peptide - NP_056575
RefSeq Peptide - NP_001272762
RefSeq Peptide - NP_001272764
swissprot - B2RSM1
swissprot - S4R1R3
swissprot - D3Z2E1
swissprot - Q9JHI8
Ensembl - ENSMUSG00000030562
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOX4ENSDARG00000114937Danio rerio
 NOX4ENSGALG00000017235Gallus gallus
 NOX4ENSG00000086991Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cybb / Q61093 / Cytochrome b-245 heavy chain / P04839* / cytochrome b-245 beta chain*ENSMUSG0000001534037
Nox1 / Q8CIZ9 / NADPH oxidase 1 / Q9Y5S8*ENSMUSG0000003125736
Nox3 / Q672J9 / NADPH oxidase 3 / Q9HBY0*ENSMUSG0000002380235
Duox1 / dual oxidase 1 / Q9NRD9*ENSMUSG0000003326828
Duox2 / dual oxidase 2 / Q9NRD8*ENSMUSG0000006845227


Protein motifs (from Interpro)
Interpro ID Name
 IPR000778  Cytochrome b245, heavy chain
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006801 superoxide metabolic process ISO
 biological_processGO:0007568 aging IEA
 biological_processGO:0007569 cell aging IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010467 gene expression ISO
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0042554 superoxide anion generation IDA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IMP
 biological_processGO:0045453 bone resorption IMP
 biological_processGO:0050667 homocysteine metabolic process ISO
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0055114 oxidation-reduction process ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEP
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0072593 reactive oxygen species metabolic process ISS
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IMP
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0016174 NAD(P)H oxidase activity IEA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IMP
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor IEA
 molecular_functionGO:0072341 modified amino acid binding ISO


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myh9tm5Rsad/Myh9tm5Rsad,Tg(Lck-cre)#Nik/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myh9tm5Rsad/Myh9tm5Rsad,Tg(Lck-cre)#Nik/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: TriobpGt(YHB226)Byg/TriobpGt(YHB226)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Nox4tm1.1Hwsc/Nox4tm1.1Hwsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nox4tm1Kkr/Nox4tm1Kkr
Genetic Background: B6.129-Nox4tm1Kkr

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nox4tm1.1Ams/Nox4tm1.1Ams
Genetic Background: B6.129-Nox4tm1.1Ams

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nox4tm1.1Ams/Nox4tm1.1Ams
Genetic Background: B6.129-Nox4tm1.1Ams

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: TriobpGt(YHB226)Byg/TriobpGt(YHB226)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Nox4tm1.1Ams/Nox4tm1.1Ams
Genetic Background: B6.129-Nox4tm1.1Ams

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: TriobpGt(YHB226)Byg/TriobpGt(YHB226)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: TriobpGt(YHB226)Byg/TriobpGt(YHB226)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nox4tm1Kkr/Nox4tm1Kkr
Genetic Background: B6.129-Nox4tm1Kkr

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010181 decreased susceptibility to weight loss "smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nox4tm1Kkr/Nox4tm1Kkr
Genetic Background: B6.129-Nox4tm1Kkr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015340 Cybb / Q61093 / Cytochrome b-245 heavy chain / P04839* / cytochrome b-245 beta chain*  / complex
 ENSMUSG00000006519 Cyba / Q61462 / Cytochrome b-245 light chain / P13498* / cytochrome b-245 alpha chain*  / complex






 

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