ENSMUSG00000068452


Mus musculus

Features
Gene ID: ENSMUSG00000068452
  
Biological name :Duox2
  
Synonyms : dual oxidase 2 / Duox2
  
Possible biological names infered from orthology : Q9NRD8
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 122279247
Gene end: 122298165
  
Corresponding Affymetrix probe sets: 10486956 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000050314
NCBI entrez gene - 214593     See in Manteia.
MGI - MGI:3036280
RefSeq - NM_177610
RefSeq - XM_006499110
RefSeq Peptide - NP_808278
swissprot - A2AQ99
Ensembl - ENSMUSG00000068452
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 duoxENSDARG00000062632Danio rerio
 ENSGALG00000041510Gallus gallus
 DUOX2ENSG00000140279Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Duox1 / dual oxidase 1 / Q9NRD9*ENSMUSG0000003326878
Cybb / Q61093 / Cytochrome b-245 heavy chain / P04839* / cytochrome b-245 beta chain*ENSMUSG0000001534011
Nox1 / Q8CIZ9 / NADPH oxidase 1 / Q9Y5S8*ENSMUSG0000003125711
Nox3 / Q672J9 / NADPH oxidase 3 / Q9HBY0*ENSMUSG0000002380210
Nox4 / Q9JHI8 / NADPH oxidase 4 / Q9NPH5*ENSMUSG0000003056210


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR010255  Haem peroxidase
 IPR011992  EF-hand domain pair
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR018247  EF-Hand 1, calcium-binding site
 IPR019791  Haem peroxidase, animal type
 IPR034818  Dual oxidase 2
 IPR034821  Dual oxidase, peroxidase domain
 IPR037120  Haem peroxidase domain superfamily, animal type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030282 bone mineralization IMP
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042403 thyroid hormone metabolic process IMP
 biological_processGO:0042445 hormone metabolic process IMP
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0048855 adenohypophysis morphogenesis IMP
 biological_processGO:0050665 hydrogen peroxide biosynthetic process IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0005509 calcium ion binding ISO
 molecular_functionGO:0016174 NAD(P)H oxidase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA


Pathways (from Reactome)
Pathway description
Thyroxine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
Show

Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0003498 thyroid hyperplasia 
Show

Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0003503 decreased activity of thyroid 
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Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0004163 abnormal adenophysis morphology "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0004664 delayed inner ear development "slowed progression to structurally mature components of the labyrinth, including the semicircular canals, vestibule and cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0011721 abnormal bone mineralization involved in bone maturation "anomaly in the deposition of calcium phosphate in bone tissue, involved in the progression of the developing skeleton from its formation to its mature state" [GO:0035630]
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Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

 MP:0013618 decreased areal bone mineral density "reduction of the mineral mass per unit area of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2), with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests" [PMID:12730800, PMID:17481978]
Show

Allelic Composition: Scyl1mdf/Scyl1mdf
Genetic Background: involves: CFW * C57BL/6J * C57BR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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