ENSGALG00000027188


Gallus gallus
regulationSREBF1transcriptionbindingrnapolymeraseiidnaprocessresponseproteinsequence-specificactivitydna-templatedinsulinreceptorbiosyntheticsignalingpathwaycholesterolsecretionmitochondrionregulatoryregionproximalpromoterfactormyc-typebasichelix-loop-helixbhlh

Features
Gene ID: ENSGALG00000027188
  
Biological name :SREBF1
  
Synonyms : SREBF1 / sterol regulatory element-binding protein 1
  
Possible biological names infered from orthology : Mus musculus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 4, mRNA. / P36956 / Q9WTN3 / sterol regulatory element binding transcription factor 1
  
Species: Gallus gallus
  
Chr. number: 14
Strand: -1
Band:
Gene start: 4936539
Gene end: 4946817
  
Corresponding Affymetrix probe sets: Gga.151.1.S1_at (Chicken Array)   Gga.151.2.A1_at (Chicken Array)   Gga.151.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000055196
Ensembl peptide - ENSGALP00000060695
Ensembl peptide - ENSGALP00000043197
NCBI entrez gene - 373915     See in Manteia.
RefSeq - XM_015294109
RefSeq - NM_204126
RefSeq - XM_015294106
RefSeq - XM_015294108
RefSeq Peptide - NP_989457
swissprot - R4GLV5
swissprot - A0A1L1RPI1
swissprot - A0A1D5PQN1
Ensembl - ENSGALG00000027188
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srebf1ENSDARG00000067607Danio rerio
 P36956ENSG00000072310Homo sapiens
 Q9WTN3ENSMUSG00000020538Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SREBF2 / sterol regulatory element binding transcription factor 2 / Q12772* / Q3U1N2* / sterol regulatory element binding factor 2*ENSGALG0000004168744


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitysystem processcircadian rhythmcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusresponse to stressresponse to external stimulusresponse to abiotic stimulussmall molecule metabolic processcellular component organizationcellular developmental processmacromolecule localizationestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitysystem processcircadian rhythmcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusresponse to stressresponse to external stimulusresponse to abiotic stimulussmall molecule metabolic processcellular component organizationcellular developmental processmacromolecule localizationestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitysystem processcircadian rhythmcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusresponse to stressresponse to external stimulusresponse to abiotic stimulussmall molecule metabolic processcellular component organizationcellular developmental processmacromolecule localizationestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitysystem processcircadian rhythmcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusresponse to stressresponse to external stimulusresponse to abiotic stimulussmall molecule metabolic processcellular component organizationcellular developmental processmacromolecule localizationestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitysystem processcircadian rhythmcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusresponse to stressresponse to external stimulusresponse to abiotic stimulussmall molecule metabolic processcellular component organizationcellular developmental processmacromolecule localizationestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitysystem processcircadian rhythmcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusresponse to stressresponse to external stimulusresponse to abiotic stimulussmall molecule metabolic processcellular component organizationcellular developmental processmacromolecule localizationestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitysystem processcircadian rhythmcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusresponse to stressresponse to external stimulusresponse to abiotic stimulussmall molecule metabolic processcellular component organizationcellular developmental processmacromolecule localizationestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitysystem processcircadian rhythmcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusresponse to stressresponse to external stimulusresponse to abiotic stimulussmall molecule metabolic processcellular component organizationcellular developmental processmacromolecule localizationestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitysystem processcircadian rhythmcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusresponse to stressresponse to external stimulusresponse to abiotic stimulussmall molecule metabolic processcellular component organizationcellular developmental processmacromolecule localizationestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processregulation of biological qualitysystem processcircadian rhythmcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusresponse to stressresponse to external stimulusresponse to abiotic stimulussmall molecule metabolic processcellular component organizationcellular developmental processmacromolecule localizationestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular localizationnitrognitrogen compound metabolic processbiosynbiosynthetic processcellulcellular metabolic processprimarprimary metabolic processorganiorganic substance metabolic processregularegulation of biological qualitysystemsystem processcircadcircadian rhythmcell ccell communicationresponresponse to endogenous stimulusresponresponse to chemicalcellulcellular response to stimulusresponresponse to stressresponresponse to external stimulusresponresponse to abiotic stimulussmall small molecule metabolic processcellulcellular component organizationcellulcellular developmental processmacrommacromolecule localizationestablestablishment of localizationcatabocatabolic processprocesprocess utilizing autophagic mechanismcellulcellular localization
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitychromatin bindingprotein bindingorganic cyclic compound bindorganic cyclic compound bindingheterocyclic compound bindinheterocyclic compound bindingDNA-binding transcription faDNA-binding transcription factor activitychromatin bindingchromatin bindingprotein bindingprotein binding
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0003062 regulation of heart rate by chemical signal IEA
 biological_processGO:0006351 transcription, DNA-templated IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0008610 lipid biosynthetic process IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009416 response to light stimulus IDA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process IEA
 biological_processGO:0019217 regulation of fatty acid metabolic process IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0031065 positive regulation of histone deacetylation IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045542 positive regulation of cholesterol biosynthetic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IEA
 biological_processGO:1903214 regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0032810 sterol response element binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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