ENSGALG00000031457


Gallus gallus

Features
Gene ID: ENSGALG00000031457
  
Biological name :TDG
  
Synonyms : TDG / thymine DNA glycosylase
  
Possible biological names infered from orthology : Mus musculus thymine DNA glycosylase (Tdg), transcript variant 3, mRNA. / P56581 / Q13569
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 54743480
Gene end: 54753986
  
Corresponding Affymetrix probe sets: Gga.3142.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045187
NCBI entrez gene - 395510     See in Manteia.
RefSeq - NM_204750
RefSeq Peptide - NP_990081
swissprot - Q9PUA4
Ensembl - ENSGALG00000031457
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdg.1ENSDARG00000013004Danio rerio
 tdg.2ENSDARG00000086450Danio rerio
 TDGENSG00000139372Homo sapiens
 TdgENSMUSG00000034674Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003310  G/U mismatch-specific uracil/thymine-DNA glycosylase
 IPR005122  Uracil-DNA glycosylase-like
 IPR015637  G/U mismatch-specific DNA glycosylase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006285 base-excision repair, AP site formation IEA
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0009790 embryo development IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0035562 negative regulation of chromatin binding IEA
 biological_processGO:0040029 regulation of gene expression, epigenetic IEA
 biological_processGO:0045008 depyrimidination TAS
 biological_processGO:0080111 DNA demethylation IEA
 biological_processGO:1902544 regulation of DNA N-glycosylase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0004844 uracil DNA N-glycosylase activity IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity TAS
 molecular_functionGO:0030983 mismatched DNA binding IEA
 molecular_functionGO:0031402 sodium ion binding IEA
 molecular_functionGO:0031404 chloride ion binding IEA
 molecular_functionGO:0032183 SUMO binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity IEA


Pathways (from Reactome)
Pathway description
Cleavage of the damaged pyrimidine
SUMOylation of DNA damage response and repair proteins
Resolution of Abasic Sites (AP sites)
Depyrimidination
TET1,2,3 and TDG demethylate DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000031457 TDG / thymine DNA glycosylase / P56581* / Q13569* / Mus musculus thymine DNA glycosylase (Tdg), transcript variant 3, mRNA.*  / reaction






 

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