ENSGALG00000031642


Gallus gallus

Features
Gene ID: ENSGALG00000031642
  
Biological name :ILK
  
Synonyms : ILK / integrin linked kinase
  
Possible biological names infered from orthology : Integrin-linked protein kinase / O55222 / Q13418
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 194378828
Gene end: 194384235
  
Corresponding Affymetrix probe sets: Gga.3404.1.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000058869
Ensembl peptide - ENSGALP00000048764
NCBI entrez gene - 374018     See in Manteia.
RefSeq - XM_015280909
RefSeq - NM_204194
RefSeq Peptide - NP_989525
swissprot - Q9DF58
swissprot - A0A1L1RJE7
Ensembl - ENSGALG00000031642
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ilkENSDARG00000056964Danio rerio
 ILKENSG00000166333Homo sapiens
 IlkENSMUSG00000030890Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNNI3K / Q59H18* / Q5GIG6* / FPGT-TNNI3K* / FPGT-TNNI3K readthrough* / TNNI3 interacting kinase*ENSGALG0000001135327
MAP3K21 / mitogen-activated protein kinase kinase kinase 21 / Q5TCX8* / Q8VDG6*ENSGALG0000001100821
MAP3K9 / mitogen-activated protein kinase kinase kinase 9 / P80192* / Q3U1V8*ENSGALG0000003732621
MAP3K13 / mitogen-activated protein kinase kinase kinase 13 / O43283* / Q1HKZ5*ENSGALG0000000665520
MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*ENSGALG0000001559615
MAP3K20 / mitogen-activated protein kinase kinase kinase 20 / Q9ESL4* / Q9NYL2*ENSGALG0000003523715
MOS / P10741 / Serine/threonine-protein kinase mos / P00540* / MOS proto-oncogene, serine/threonine kinase*ENSGALG0000004208215
Q12852* / Q60700* / MAP3K12* / mitogen-activated protein kinase kinase kinase 12* / Mus musculus mitogen-activated protein kinase kinase kinase 12 (Map3k12), transcript variant 3, mRNA.*ENSGALG000000315727


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002110  Ankyrin repeat
 IPR011009  Protein kinase-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0010761 fibroblast migration IEA
 biological_processGO:0014044 Schwann cell development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0021675 nerve development IEA
 biological_processGO:0022011 myelination in peripheral nervous system IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Localization of the PINCH-ILK-PARVIN complex to focal adhesions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007145 ITGB1 / integrin subunit beta 1 / P05556* / P09055* / Integrin beta-1 *  / complex / reaction






 

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