ENSGALG00000007145


Gallus gallus

Features
Gene ID: ENSGALG00000007145
  
Biological name :ITGB1
  
Synonyms : integrin subunit beta 1 / ITGB1
  
Possible biological names infered from orthology : Integrin beta-1 / P05556 / P09055
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 14045947
Gene end: 14087348
  
Corresponding Affymetrix probe sets: Gga.111.1.S1_s_at (Chicken Array)   Gga.2015.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054354
Ensembl peptide - ENSGALP00000011559
NCBI entrez gene - 374058     See in Manteia.
RefSeq - XM_015281260
RefSeq - NM_001039254
RefSeq Peptide - NP_001034343
swissprot - A0A1D5PNB4
swissprot - F1N8N7
Ensembl - ENSGALG00000007145
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01058721.1ENSDARG00000109929Danio rerio
 itgb1aENSDARG00000071863Danio rerio
 itgb1bENSDARG00000104484Danio rerio
 ITGB1ENSG00000150093Homo sapiens
 Itgb1ENSMUSG00000025809Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGB2 / integrin beta-2 precursor / Itgb2l* / P05107* / Q3UV74* / integrin subunit beta 2* / Integrin beta-2-like protein *ENSGALG0000000751147
ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*ENSGALG0000000037943
ITGB5 / integrin beta-5 precursor / P18084* / integrin subunit beta 5*ENSGALG0000002976641
ITGB6 / integrin subunit beta 6 / P18564* / Q9Z0T9* / Integrin beta-6 *ENSGALG0000001114140
ITGB4 / integrin subunit beta 4 / A2A863* / P16144* / Integrin beta-4 *ENSGALG0000000238933
ITGB8 / integrin subunit beta 8 / P26012*ENSGALG0000001087531
ITGBL1 / integrin subunit beta like 1 / O95965* / Q8VDV0* / Integrin beta-like protein 1 *ENSGALG0000001686713


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR002369  Integrin beta subunit, VWA domain
 IPR012896  Integrin beta subunit, tail
 IPR013111  EGF-like domain, extracellular
 IPR014836  Integrin beta subunit, cytoplasmic domain
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR027071  Integrin beta-1 subunit
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001708 cell fate specification IEA
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007161 calcium-independent cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008354 germ cell migration IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0010710 regulation of collagen catabolic process IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021943 formation of radial glial scaffolds IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0033627 cell adhesion mediated by integrin IEA
 biological_processGO:0033631 cell-cell adhesion mediated by integrin IEA
 biological_processGO:0034113 heterotypic cell-cell adhesion IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048333 mesodermal cell differentiation IEA
 biological_processGO:0048675 axon extension IEA
 biological_processGO:0048738 cardiac muscle tissue development IEA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:0050901 leukocyte tethering or rolling IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0071711 basement membrane organization IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:2000273 positive regulation of signaling receptor activity IEA
 biological_processGO:2000811 negative regulation of anoikis IEA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0034665 integrin alpha1-beta1 complex IEA
 cellular_componentGO:0034666 integrin alpha2-beta1 complex IEA
 cellular_componentGO:0034667 integrin alpha3-beta1 complex IEA
 cellular_componentGO:0034677 integrin alpha7-beta1 complex IEA
 cellular_componentGO:0034680 integrin alpha10-beta1 complex IEA
 cellular_componentGO:0034681 integrin alpha11-beta1 complex IEA
 cellular_componentGO:0035748 myelin sheath abaxonal region IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071438 invadopodium membrane IEA
 cellular_componentGO:0097060 synaptic membrane IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0019960 C-X3-C chemokine binding IEA
 molecular_functionGO:0043236 laminin binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:0098639 collagen binding involved in cell-matrix adhesion IEA
 molecular_functionGO:1990782 protein tyrosine kinase binding IPI


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Fibronectin matrix formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Basigin interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
MET activates PTK2 signaling
MET interacts with TNS proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001472 JAM3 / junctional adhesion molecule 3 / Q9BX67* / Q9D8B7* / Junctional adhesion molecule C *  / complex / reaction
 ENSGALG00000003578 FN1 / fibronectin 1 / P02751* / P11276* / Fibronectin Anastellin*  / complex / reaction
 ENSGALG00000001328 BSG / P17790 / Basigin / P18572* / P35613* / basigin (Ok blood group)*  / complex / reaction
 ENSGALG00000003283 COMP / cartilage oligomeric matrix protein / P49747* / Q9R0G6*  / complex / reaction
 ENSGALG00000008007 ITGA11 / integrin subunit alpha 11 / Q9UKX5*  / complex
 ENSGALG00000008747 ITGA8 / integrin alpha-8 precursor / A2ARA8* / P53708* / integrin subunit alpha 8* / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain*  / complex
 ENSGALG00000014903 ITGA2 / integrin subunit alpha 2 / P17301* / Q62469* / Integrin alpha-2 *  / complex
 ENSGALG00000014891 ITGA1 / integrin alpha-1 precursor / Q3V3R4* / P56199* / Integrin alpha-1 * / integrin subunit alpha 1*  / complex
 ENSGALG00000034007 ITGA6 / integrin alpha-6 precursor / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*  / complex
 ENSGALG00000041577 ITGA4 / integrin subunit alpha 4 / P13612*  / complex
 ENSGALG00000031642 ILK / integrin linked kinase / O55222* / Q13418* / Integrin-linked protein kinase *  / complex / reaction
 ENSGALG00000005257 VCAM1 / vascular cell adhesion molecule 1 / P19320* / P29533*  / complex / reaction
 ENSGALG00000011271 LUM / P51890 / Lumican / P51884* / P51885*  / complex / reaction
 ENSGALG00000015746 JAM2 / junctional adhesion molecule 2 / P57087* / Q9JI59* / Junctional adhesion molecule B *  / complex / reaction
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000039990 TNC / tenascin C / P24821* / Q80YX1*  / complex / reaction
 ENSGALG00000004620 LAMC1 / laminin subunit gamma 1 / P11047*  / complex / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction






 

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