ENSDARG00000071863


Danio rerio

Features
Gene ID: ENSDARG00000071863
  
Biological name :itgb1a
  
Synonyms : integrin, beta 1a / itgb1a
  
Possible biological names infered from orthology : Integrin beta-1 / integrin subunit beta 1 / ITGB1 / P05556 / P09055
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 1110138
Gene end: 1151483
  
Corresponding Affymetrix probe sets: Dr.23073.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000039699
Ensembl peptide - ENSDARP00000143985
NCBI entrez gene - 556734     See in Manteia.
swissprot - A0A286Y9W0
swissprot - F1QG85
ZFIN ID - ZDB-GENE-060803-2
Ensembl - ENSDARG00000071863
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ITGB1ENSGALG00000007145Gallus gallus
 ITGB1ENSG00000150093Homo sapiens
 Itgb1ENSMUSG00000025809Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
itgb1b.1 / integrin, beta 1b.1ENSDARG0000005323268
itgb1b / integrin, beta 1b / ITGB1* / P05556* / integrin subunit beta 1*ENSDARG0000010448453
itgb1b.1 / itgb1b.2 / integrin, beta 1b.2ENSDARG0000002268949
itgb3b / integrin beta 3b / ITGB3* / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*ENSDARG0000004507043
itgb2 / integrin, beta 2 / Itgb2l* / P05107* / Q3UV74* / integrin subunit beta 2* / Integrin beta-2-like protein *ENSDARG0000001693942
itgb5 / integrin, beta 5 / P18084* / integrin subunit beta 5*ENSDARG0000001294240
itgb6 / integrin, beta 6 / P18564* / Q9Z0T9* / integrin subunit beta 6*ENSDARG0000000249439
itgb3a / integrin beta 3a / ITGB3* / P05106* / AC068234.1* / integrin subunit beta 3*ENSDARG0000005676739
itgb7 / integrin, beta 7 / P26010* / P26011* / integrin subunit beta 7*ENSDARG0000004431837
itgb4 / integrin, beta 4 / A2A863* / P16144* / integrin subunit beta 4*ENSDARG0000002850734
itgb8 / integrin, beta 8 / P26012* / integrin subunit beta 8*ENSDARG0000002822227
CABZ01058721.1 / ITGB1* / P05556* / integrin subunit beta 1*ENSDARG0000010992925
itgbl1 / integrin, beta-like 1 / O95965* / Q8VDV0* / integrin subunit beta like 1* / Integrin beta-like protein 1 *ENSDARG0000004098510


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR002369  Integrin beta subunit, VWA domain
 IPR012896  Integrin beta subunit, tail
 IPR013111  EGF-like domain, extracellular
 IPR014836  Integrin beta subunit, cytoplasmic domain
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR027071  Integrin beta-1 subunit
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001968 fibronectin binding IGI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Fibronectin matrix formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Basigin interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Laminin interactions
ECM proteoglycans
Signal transduction by L1
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001285 intersegmental vessel intersegmental vessel decreased length , abnormal
intersegmental vessel endothelial cell decreased amount , abnormal
intersegmental vessel decreased length , ameliorated
intersegmental vessel endothelial cell amount , ameliorated
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel blood vessel morphogenesis decreased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002507 itga10 / integrin, alpha 10 / O75578* / integrin subunit alpha 10*  / complex
 ENSDARG00000010785 thbs1b / thrombospondin 1b / THBS1* / P07996* / thrombospondin 1*  / complex / reaction
 ENSDARG00000006353 itga5 / integrin, alpha 5 (fibronectin receptor, alpha polypeptide) / P08648* / P11688* / integrin subunit alpha 5* / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain*  / complex
 ENSDARG00000021948 tnc / tenascin C / P24821* / Q80YX1*  / complex / reaction
 ENSDARG00000036279 lamc1 / Q1LVF0 / laminin, gamma 1 / P11047* / laminin subunit gamma 1*  / complex / reaction
 ENSDARG00000032435 itga9 / integrin, alpha 9 / Q13797* / integrin subunit alpha 9*  / complex
 ENSDARG00000036086 itga11a / integrin, alpha 11a / ITGA11* / Q9UKX5* / integrin subunit alpha 11*  / complex
 ENSDARG00000002956 si:dkey-32n7.4 / ITGAD* / ITGAM* / ITGAX* / Q13349* / P11215* / P20702* / Q9QXH4* / Q3V0T4* / integrin alpha M* / Integrin alpha-X * / Integrin alpha-D * / integrin subunit alpha X* / integ...  / complex
 ENSDARG00000056964 ilk / integrin-linked kinase / O55222* / Q13418* / Integrin-linked protein kinase *  / complex / reaction
 ENSDARG00000078362 zmp:0000000846 / TNC* / P24821* / tenascin C*  / complex / reaction
 ENSDARG00000006526 fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex / reaction
 ENSDARG00000079071 jam2b / junctional adhesion molecule 2b / JAM2* / P57087* / Q9JI59* / junctional adhesion molecule 2* / Junctional adhesion molecule B *  / complex / reaction
 ENSDARG00000019815 fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex / reaction
 ENSDARG00000114589 jam3a / junctional adhesion molecule 3a / JAM3* / Q9BX67* / Q9D8B7* / junctional adhesion molecule 3* / Junctional adhesion molecule C *  / complex / reaction
 ENSDARG00000062974 itga2.2 / integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2 / ITGA2* / P17301* / Q62469* / Integrin alpha-2 * / integrin subunit alpha 2*  / complex
 ENSDARG00000045580 lum / lumican / P51884* / P51885*  / complex / reaction
 ENSDARG00000002084 lamb2 / laminin, beta 2 (laminin S) / P55268* / Q61292* / laminin subunit beta 2*  / complex / reaction
 ENSDARG00000098431 COMP / si:ch211-43f4.1 / P49747* / Q9R0G6* / cartilage oligomeric matrix protein*  / complex / reaction
 ENSDARG00000053831 vtnb / vitronectin b / VTN* / P04004* / P29788* / AC002094.3* / vitronectin*  / complex / reaction
 ENSDARG00000037917 itga3a / integrin, alpha 3a / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*  / complex
 ENSDARG00000062479 vcam1b / vascular cell adhesion molecule 1b / VCAM1* / P19320* / P29533* / vascular cell adhesion molecule 1*  / complex / reaction
 ENSDARG00000012824 itga3b / integrin, alpha 3b / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*  / complex
 ENSDARG00000103056 itga4 / integrin alpha 4 / P13612* / integrin subunit alpha 4*  / complex






 

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