ENSDARG00000036279


Danio rerio

Features
Gene ID: ENSDARG00000036279
  
Biological name :lamc1
  
Synonyms : lamc1 / laminin, gamma 1 / Q1LVF0
  
Possible biological names infered from orthology : laminin subunit gamma 1 / P11047
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 35880600
Gene end: 35979178
  
Corresponding Affymetrix probe sets: Dr.18579.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000024860
NCBI entrez gene - 286832     See in Manteia.
RefSeq - NM_173277
RefSeq Peptide - NP_775384
swissprot - Q1LVF0
ZFIN ID - ZDB-GENE-021226-3
Ensembl - ENSDARG00000036279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LAMC1ENSGALG00000004620Gallus gallus
 LAMC1ENSG00000135862Homo sapiens
 Lamc1ENSMUSG00000026478Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lamc3 / laminin, gamma 3 / Q9R0B6* / Q9Y6N6* / laminin subunit gamma 3*ENSDARG0000009357240
lama5 / laminin, alpha 5 / O15230* / Q61001* / laminin subunit alpha 5*ENSDARG0000005854328
lama1 / laminin, alpha 1 / P25391* / laminin subunit alpha 1*ENSDARG0000010227722
lamb2 / laminin, beta 2 (laminin S) / P55268* / Q61292* / laminin subunit beta 2*ENSDARG0000000208419
lamb2l / laminin, beta 2-likeENSDARG0000003395019
lamb1a / laminin, beta 1a / LAMB1* / P02469* / P07942* / laminin subunit beta 1*ENSDARG0000010120919
lamb4 / laminin, beta 4 / A4D0S4* / laminin subunit beta 4*ENSDARG0000003913318
lamb1b / laminin, beta 1b / LAMB1* / P02469* / P07942* / laminin subunit beta 1*ENSDARG0000004552418
lama4 / laminin, alpha 4 / P97927* / Q16363* / laminin subunit alpha 4*ENSDARG0000002078511
lamc2 / laminin, gamma 2 / Q13753* / laminin subunit gamma 2*ENSDARG0000006828810
lama3 / laminin, alpha 3 / Q16787* / Q61789* / laminin subunit alpha 3* / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA.*ENSDARG0000007146210
lama2 / laminin, alpha 2 / P24043* / laminin subunit alpha 2*ENSDARG0000009939010
si:ch211-241e1.3 / LAMA3* / Q16787* / Q61789* / laminin subunit alpha 3* / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA.*ENSDARG000000226159
ntn4 / netrin 4 / Q9HB63* / Q9JI33*ENSDARG000001020668
CABZ01065423.1 / LAMA2* / P24043* / laminin subunit alpha 2*ENSDARG000001120198
si:dkey-202e22.2ENSDARG000000612607
CABZ01092781.1 / LAMB3* / Q13751* / laminin subunit beta 3*ENSDARG000001100401


Protein motifs (from Interpro)
Interpro ID Name
 IPR000034  Laminin IV
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR031082  Laminin subunit gamma-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007517 muscle organ development IMP
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0007634 optokinetic behavior IMP
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0048570 notochord morphogenesis IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0050908 detection of light stimulus involved in visual perception IMP
 biological_processGO:0061053 somite development IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IEA


Pathways (from Reactome)
Pathway description
Laminin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MET activates PTK2 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain shape , abnormal
brain quality , abnormal
brain surface feature shape , abnormal
brain disorganized , abnormal
brain malformed , abnormal
Show

 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer dispersed , abnormal
Show

 ZFA:0000029 hindbrain hindbrain quality , abnormal
hindbrain morphology , abnormal
Show

 ZFA:0000035 lens lens decreased size , abnormal
lens protruding , abnormal
lens structure , abnormal
lens perforate , abnormal
lens mislocalised , abnormal
lens degenerate , abnormal
lens disorganized , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
anatomical structure decreased amount , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
midbrain hindbrain boundary shape , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000106 extension extension quality , abnormal
Show

 ZFA:0000107 eye eye morphology , abnormal
eye quality , abnormal
eye decreased size , abnormal
eye malformed , abnormal
eye mislocalised ventrally , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
fourth ventricle decreased size , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
Show

 ZFA:0000135 notochord notochord structure , abnormal
notochord poorly differentiated , abnormal
notochord quality , abnormal
notochord undifferentiated , abnormal
notochord decreased thickness , abnormal
notochord apoptotic , abnormal
notochord structure, cavities , abnormal
notochord lacks parts or has fewer parts of type cell rough endoplasmic reticulum, abnormal
notochord basement membrane disorganized , abnormal
notochord vacuole decreased size , abnormal
notochord vacuole decreased amount , abnormal
notochord morphology , abnormal
notochord cell structure , abnormal
notochord undulate , abnormal
notochord collagen type IV trimer absent , abnormal
Show

 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer decreased thickness , abnormal
Show

 ZFA:0000152 retina retina decreased size , abnormal
retina quality , abnormal
Show

 ZFA:0000155 somite somite quality , abnormal
somite morphology , abnormal
somite disorganized , abnormal
somite condensed , abnormal
somite shape , abnormal
somite muscle pioneer absent , abnormal
Show

 ZFA:0000159 tectal ventricle tectal ventricle decreased size , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000318 brainstem and spinal white matter brainstem and spinal white matter axon decreased amount , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II morphology , abnormal
Show

 ZFA:0000598 testis testis structure , abnormal
Show

 ZFA:0001056 myotome myotome muscle tendon junction morphology , abnormal
myotome U-shaped , abnormal
myotome increased amount , abnormal
myotome muscle tendon junction spatial pattern , abnormal
myotome muscle tendon junction increased amount , abnormal
myotome muscle tendon junction decreased amount , abnormal
myotome shape , abnormal
myotome muscle tendon junction malformed , abnormal
myotome muscle cell detached from myotome muscle tendon junction, abnormal
Show

 ZFA:0001094 whole organism whole organism shape , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism decreased length , abnormal
whole organism curved dorsal , abnormal
Show

 ZFA:0001114 head head flat , abnormal
head edematous , abnormal
head swollen , abnormal
Show

 ZFA:0001115 trunk trunk decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
Show

 ZFA:0001259 forebrain ventricle forebrain ventricle decreased size , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel aplastic , abnormal
Show

 ZFA:0001367 forebrain midbrain boundary forebrain midbrain boundary increased width , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell decreased amount , abnormal
slow muscle cell degenerate , abnormal
slow muscle cell detached from slow muscle cell , abnormal
slow muscle cell myosin filament disorganized , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell myosin filament disorganized , abnormal
fast muscle cell circular , abnormal
fast muscle cell decreased length , abnormal
fast muscle cell muscle tendon junction increased amount , abnormal
Show

 ZFA:0009149 Mauthner neuron Mauthner neuron axon mislocalised medially , abnormal
Show

 ZFA:0009306 neuroepithelial cell neuroepithelial cell apical part of cell decreased width , abnormal
neuroepithelial cell basal part of cell increased width , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon misrouted , abnormal
retinal ganglion cell axon ipsilateral to eye , abnormal
Show

 ZFA:0009369 fast muscle myoblast fast muscle myoblast decreased length , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002084 lamb2 / laminin, beta 2 (laminin S) / P55268* / Q61292* / laminin subunit beta 2*  / complex
 ENSDARG00000071863 itgb1a / integrin, beta 1a / ITGB1* / P05556* / P09055* / Integrin beta-1 * / integrin subunit beta 1*  / complex / reaction
 ENSDARG00000037917 itga3a / integrin, alpha 3a / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*  / complex / reaction
 ENSDARG00000012824 itga3b / integrin, alpha 3b / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*  / complex / reaction






 

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