ENSDARG00000101209


Danio rerio

Features
Gene ID: ENSDARG00000101209
  
Biological name :lamb1a
  
Synonyms : lamb1a / laminin, beta 1a
  
Possible biological names infered from orthology : LAMB1 / laminin subunit beta 1 / P02469 / P07942
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 31546828
Gene end: 31629095
  
Corresponding Affymetrix probe sets: Dr.4129.1.S1_at (Zebrafish Array)   NM_173275_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000131540
Ensembl peptide - ENSDARP00000141956
NCBI entrez gene - 286830     See in Manteia.
RefSeq - NM_173275
RefSeq Peptide - NP_775382
swissprot - A0A0R4IY30
swissprot - A0A0R4IDN1
swissprot - A0A0R4IB69
ZFIN ID - ZDB-GENE-021226-1
Ensembl - ENSDARG00000101209
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LAMB1ENSGALG00000007905Gallus gallus
 LAMB1ENSG00000091136Homo sapiens
 Lamb1ENSMUSG00000002900Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lamb1b / laminin, beta 1b / LAMB1* / P02469* / P07942* / laminin subunit beta 1*ENSDARG0000004552458
lamb2 / laminin, beta 2 (laminin S) / P55268* / Q61292* / laminin subunit beta 2*ENSDARG0000000208455
lamb2l / laminin, beta 2-likeENSDARG0000003395045
lamb4 / laminin, beta 4 / A4D0S4* / laminin subunit beta 4*ENSDARG0000003913338
lama5 / laminin, alpha 5 / O15230* / Q61001* / laminin subunit alpha 5*ENSDARG0000005854325
lama1 / laminin, alpha 1 / P25391* / laminin subunit alpha 1*ENSDARG0000010227720
lamc1 / Q1LVF0 / laminin, gamma 1 / P11047* / laminin subunit gamma 1*ENSDARG0000003627917
lamc3 / laminin, gamma 3 / Q9R0B6* / Q9Y6N6* / laminin subunit gamma 3*ENSDARG0000009357216
lama4 / laminin, alpha 4 / P97927* / Q16363* / laminin subunit alpha 4*ENSDARG0000002078510
si:dkey-202e22.2ENSDARG0000006126010
ntn4 / netrin 4 / Q9HB63* / Q9JI33*ENSDARG0000010206610
lama2 / laminin, alpha 2 / P24043* / laminin subunit alpha 2*ENSDARG000000993909
CABZ01065423.1 / LAMA2* / P24043* / laminin subunit alpha 2*ENSDARG000001120198
lama3 / laminin, alpha 3 / Q16787* / Q61789* / laminin subunit alpha 3* / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA.*ENSDARG000000714627
si:ch211-241e1.3 / LAMA3* / Q16787* / Q61789* / laminin subunit alpha 3* / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA.*ENSDARG000000226156
lamc2 / laminin, gamma 2 / Q13753* / laminin subunit gamma 2*ENSDARG000000682886
CABZ01092781.1 / LAMB3* / Q13751* / laminin subunit beta 3*ENSDARG000001100400


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR013015  Laminin IV type B
 IPR013032  EGF-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IMP
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007517 muscle organ development IMP
 biological_processGO:0007634 optokinetic behavior IMP
 biological_processGO:0014028 notochord formation IMP
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0048592 eye morphogenesis IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0050908 detection of light stimulus involved in visual perception IMP
 biological_processGO:0055016 hypochord development IMP
 biological_processGO:0061053 somite development IMP
 biological_processGO:1902017 regulation of cilium assembly IMP


Pathways (from Reactome)
Pathway description
Laminin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MET activates PTK2 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle motile cilium decreased length , abnormal
Kupffers vesicle motile cilium decreased functionality , abnormal
Show

 ZFA:0000008 brain brain necrotic , abnormal
brain morphology , abnormal
brain surface feature shape , abnormal
brain disorganized , abnormal
brain shape , abnormal
Show

 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer dispersed , abnormal
Show

 ZFA:0000029 hindbrain hindbrain quality , abnormal
hindbrain morphology , abnormal
Show

 ZFA:0000031 hypochord hypochord morphology , abnormal
Show

 ZFA:0000035 lens lens protruding , abnormal
lens structure , abnormal
lens perforate , abnormal
lens mislocalised , abnormal
lens degenerate , abnormal
lens disorganized , abnormal
lens decreased size , abnormal
lens displaced , abnormal
lens hypoplastic , abnormal
lens malformed , abnormal
lens aplastic , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
midbrain hindbrain boundary shape , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000059 postoptic commissure postoptic commissure decreased size , abnormal
postoptic commissure defasciculated , abnormal
postoptic commissure has fewer parts of type astrocyte , abnormal
postoptic commissure commissural neuron axon guidance disrupted , abnormal
postoptic commissure astrocyte mislocalised , abnormal
Show

 ZFA:0000107 eye eye quality , abnormal
eye morphology , abnormal
eye decreased size , abnormal
eye mislocalised ventrally , abnormal
eye shape , abnormal
Show

 ZFA:0000108 fin fin morphology , abnormal
fin broken , abnormal
fin epithelium mislocalised , abnormal
Show

 ZFA:0000109 forebrain forebrain commissural neuron axon guidance disrupted , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
fourth ventricle decreased size , abnormal
Show

 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm mislocalised , abnormal
lateral plate mesoderm bilateral symmetry , abnormal
lateral plate mesoderm disorganized , abnormal
lateral plate mesoderm laminin complex decreased amount , abnormal
Show

 ZFA:0000123 liver liver bilateral symmetry , abnormal
Show

 ZFA:0000124 liver primordium liver primordium bilateral symmetry , abnormal
Show

 ZFA:0000135 notochord notochord quality , abnormal
notochord undifferentiated , abnormal
notochord poorly differentiated , abnormal
notochord structure , abnormal
notochord cellular quality , abnormal
notochord undulate , abnormal
notochord apoptotic , abnormal
notochord basement membrane disorganized , abnormal
notochord vacuole decreased size , abnormal
notochord vacuole decreased amount , abnormal
notochord morphology , abnormal
notochord cell structure , abnormal
notochord moderately well differentiated , abnormal
notochord hypotrophic , abnormal
notochord decreased thickness , abnormal
Show

 ZFA:0000140 pancreas pancreas bilateral symmetry , abnormal
pancreas endocrine cell mislocalised , abnormal
Show

 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer decreased thickness , abnormal
Show

 ZFA:0000152 retina retina quality , abnormal
retina decreased size , abnormal
Show

 ZFA:0000155 somite somite quality , abnormal
somite condensed , abnormal
somite morphology , abnormal
somite flattened , abnormal
somite malformed , abnormal
somite laminin complex decreased amount , abnormal
Show

 ZFA:0000159 tectal ventricle tectal ventricle decreased size , abnormal
Show

 ZFA:0000254 pancreas primordium pancreas primordium bilateral symmetry , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000318 brainstem and spinal white matter brainstem and spinal white matter axon decreased amount , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II morphology , abnormal
cranial nerve II decreased size , abnormal
cranial nerve II decreased thickness , abnormal
cranial nerve II defasciculated , abnormal
Show

 ZFA:0001056 myotome myotome muscle tendon junction morphology , abnormal
myotome shape , abnormal
myotome decreased thickness , abnormal
myotome U-shaped , abnormal
Show

 ZFA:0001058 caudal fin caudal fin distal region absent , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism decreased length , abnormal
whole organism bent , abnormal
whole organism curved dorsal , abnormal
Show

 ZFA:0001108 anterior commissure anterior commissure has fewer parts of type astrocyte , abnormal
anterior commissure astrocyte mislocalised , abnormal
Show

 ZFA:0001114 head head cuboid , abnormal
head decreased size , abnormal
Show

 ZFA:0001115 trunk trunk decreased length , abnormal
trunk curved dorsal , abnormal
trunk shortened , abnormal
Show

 ZFA:0001117 post-vent region post-vent region shortened , abnormal
Show

 ZFA:0001135 neural tube neural tube laminin complex decreased amount , abnormal
Show

 ZFA:0001259 forebrain ventricle forebrain ventricle decreased size , abnormal
Show

 ZFA:0001269 regenerating fin regenerating fin decreased length , abnormal
regenerating fin decreased length , ameliorated
regenerating fin bone element absent , abnormal
regenerating fin osteoblast absent , abnormal
regenerating fin osteoblast accumulation bone element distal region, abnormal
Show

 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel aplastic , abnormal
Show

 ZFA:0001367 forebrain midbrain boundary forebrain midbrain boundary increased width , abnormal
Show

 ZFA:0001389 regeneration epithelium regeneration epithelium decreased amount , abnormal
Show

 ZFA:0005150 basal regeneration epithelium basal regeneration epithelium position , ameliorated
basal regeneration epithelium mislocalised , abnormal
basal regeneration epithelium decreased amount , abnormal
basal regeneration epithelium apical region mislocalised , abnormal
basal regeneration epithelium basal region mislocalised , abnormal
Show

 ZFA:0005738 intestinal bulb primordium intestinal bulb primordium bilateral symmetry , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell myosin filament disorganized , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell myosin filament disorganized , abnormal
fast muscle cell muscle tendon junction increased amount , abnormal
Show

 ZFA:0009292 radial glial cell radial glial cell cell projection disorganized , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon misrouted , abnormal
retinal ganglion cell axon ipsilateral to eye , abnormal
Show

 ZFA:0009369 fast muscle myoblast fast muscle myoblast decreased length , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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