ENSDARG00000058543


Danio rerio

Features
Gene ID: ENSDARG00000058543
  
Biological name :lama5
  
Synonyms : lama5 / laminin, alpha 5
  
Possible biological names infered from orthology : laminin subunit alpha 5 / O15230 / Q61001
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 9567334
Gene end: 9768700
  
Corresponding Affymetrix probe sets: Dr.12091.1.A1_at (Zebrafish Array)   NM_001039171_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000045125
NCBI entrez gene - 321243     See in Manteia.
RefSeq - NM_001039171
RefSeq - XM_009296659
RefSeq Peptide - NP_001034260
swissprot - F1QKW3
ZFIN ID - ZDB-GENE-030131-9823
Ensembl - ENSDARG00000058543
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000005321Gallus gallus
 LAMA5ENSG00000130702Homo sapiens
 Lama5ENSMUSG00000015647Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lama1 / laminin, alpha 1 / P25391* / laminin subunit alpha 1*ENSDARG0000010227723
lama4 / laminin, alpha 4 / P97927* / Q16363* / laminin subunit alpha 4*ENSDARG0000002078514
lamb2 / laminin, beta 2 (laminin S) / P55268* / Q61292* / laminin subunit beta 2*ENSDARG0000000208412
lamb2l / laminin, beta 2-likeENSDARG0000003395012
lamc1 / Q1LVF0 / laminin, gamma 1 / P11047* / laminin subunit gamma 1*ENSDARG0000003627912
lamb4 / laminin, beta 4 / A4D0S4* / laminin subunit beta 4*ENSDARG0000003913312
lama3 / laminin, alpha 3 / Q16787* / Q61789* / laminin subunit alpha 3* / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA.*ENSDARG0000007146212
lamb1a / laminin, beta 1a / LAMB1* / P02469* / P07942* / laminin subunit beta 1*ENSDARG0000010120912
lamb1b / laminin, beta 1b / LAMB1* / P02469* / P07942* / laminin subunit beta 1*ENSDARG0000004552411
lamc3 / laminin, gamma 3 / Q9R0B6* / Q9Y6N6* / laminin subunit gamma 3*ENSDARG0000009357211
si:ch211-241e1.3 / LAMA3* / Q16787* / Q61789* / laminin subunit alpha 3* / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA.*ENSDARG0000002261510
lama2 / laminin, alpha 2 / P24043* / laminin subunit alpha 2*ENSDARG000000993907
CABZ01065423.1 / LAMA2* / P24043* / laminin subunit alpha 2*ENSDARG000001120196
CABZ01092781.1 / LAMB3* / Q13751* / laminin subunit beta 3*ENSDARG000001100405
si:dkey-202e22.2ENSDARG000000612604
ntn4 / netrin 4 / Q9HB63* / Q9JI33*ENSDARG000001020664
lamc2 / laminin, gamma 2 / Q13753* / laminin subunit gamma 2*ENSDARG000000682883


Protein motifs (from Interpro)
Interpro ID Name
 IPR000034  Laminin IV
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR009254  Laminin alpha, domain I
 IPR010307  Laminin domain II
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0033333 fin development IMP
 biological_processGO:0033334 fin morphogenesis IMP
 biological_processGO:0035138 pectoral fin morphogenesis IMP
 biological_processGO:0035141 medial fin morphogenesis IMP
 biological_processGO:0045995 regulation of embryonic development IEA
 biological_processGO:0098609 cell-cell adhesion IMP
 molecular_functionGO:0005102 signaling receptor binding IEA


Pathways (from Reactome)
Pathway description
Laminin interactions
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system morphology , abnormal
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 ZFA:0000040 median fin fold median fin fold malformed , abnormal
median fin fold edematous , abnormal
median fin fold structure , abnormal
median fin fold basement membrane punctate , abnormal
median fin fold cell-cell adherens junction composition , abnormal
median fin fold epidermis disorganized , abnormal
median fin fold epidermal cell positional polarity , abnormal
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 ZFA:0000106 extension extension decreased length , abnormal
extension hypoplastic , abnormal
extension aplastic , abnormal
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 ZFA:0000108 fin fin degenerate , abnormal
fin necrotic , abnormal
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 ZFA:0000292 surface structure surface structure quality , abnormal
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 ZFA:0001058 caudal fin caudal fin has fewer parts of type lepidotrichium , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
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 ZFA:0001161 pectoral fin pectoral fin has fewer parts of type lepidotrichium , abnormal
pectoral fin degenerate , abnormal
pectoral fin edematous , abnormal
pectoral fin structure , abnormal
pectoral fin decreased size , abnormal
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 ZFA:0001162 anal fin anal fin has fewer parts of type lepidotrichium , abnormal
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 ZFA:0001173 dorsal fin dorsal fin has fewer parts of type lepidotrichium , abnormal
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 ZFA:0001180 epidermal basal stratum epidermal basal stratum epithelial cell morphogenesis decreased process quality , abnormal
epidermal basal stratum ecto-epithelial cell oblong , abnormal
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 ZFA:0009183 epidermal cell epidermal cell shape , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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