ENSDARG00000002084


Danio rerio

Features
Gene ID: ENSDARG00000002084
  
Biological name :lamb2
  
Synonyms : lamb2 / laminin, beta 2 (laminin S)
  
Possible biological names infered from orthology : laminin subunit beta 2 / P55268 / Q61292
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 20180159
Gene end: 20258490
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000123269
NCBI entrez gene - 337767     See in Manteia.
RefSeq - NM_001243045
RefSeq Peptide - NP_001229974
swissprot - B7ZDA6
ZFIN ID - ZDB-GENE-081030-4
Ensembl - ENSDARG00000002084
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LAMB2ENSGALG00000006802Gallus gallus
 LAMB2ENSG00000172037Homo sapiens
 Lamb2ENSMUSG00000052911Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lamb1a / laminin, beta 1a / LAMB1* / P02469* / P07942* / laminin subunit beta 1*ENSDARG0000010120955
lamb1b / laminin, beta 1b / LAMB1* / P02469* / P07942* / laminin subunit beta 1*ENSDARG0000004552450
lamb2l / laminin, beta 2-likeENSDARG0000003395049
lamb4 / laminin, beta 4 / A4D0S4* / laminin subunit beta 4*ENSDARG0000003913339
lama5 / laminin, alpha 5 / O15230* / Q61001* / laminin subunit alpha 5*ENSDARG0000005854324
lama1 / laminin, alpha 1 / P25391* / laminin subunit alpha 1*ENSDARG0000010227722
lamc1 / Q1LVF0 / laminin, gamma 1 / P11047* / laminin subunit gamma 1*ENSDARG0000003627917
lamc3 / laminin, gamma 3 / Q9R0B6* / Q9Y6N6* / laminin subunit gamma 3*ENSDARG0000009357215
lama4 / laminin, alpha 4 / P97927* / Q16363* / laminin subunit alpha 4*ENSDARG0000002078510
si:dkey-202e22.2ENSDARG0000006126010
ntn4 / netrin 4 / Q9HB63* / Q9JI33*ENSDARG0000010206610
lama2 / laminin, alpha 2 / P24043* / laminin subunit alpha 2*ENSDARG000000993909
CABZ01065423.1 / LAMA2* / P24043* / laminin subunit alpha 2*ENSDARG000001120198
si:ch211-241e1.3 / LAMA3* / Q16787* / Q61789* / laminin subunit alpha 3* / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA.*ENSDARG000000226157
lama3 / laminin, alpha 3 / Q16787* / Q61789* / laminin subunit alpha 3* / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA.*ENSDARG000000714627
lamc2 / laminin, gamma 2 / Q13753* / laminin subunit gamma 2*ENSDARG000000682886
CABZ01092781.1 / LAMB3* / Q13751* / laminin subunit beta 3*ENSDARG000001100401


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR013015  Laminin IV type B
 IPR013032  EGF-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016203 muscle attachment IMP
 biological_processGO:0061053 somite development IMP
 biological_processGO:0070831 basement membrane assembly IMP


Pathways (from Reactome)
Pathway description
Laminin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MET activates PTK2 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000135 notochord notochord quality , abnormal
notochord morphology , abnormal
Show

 ZFA:0000155 somite somite degenerate , abnormal
somite disorganized , abnormal
somite myofibril detached from somite , abnormal
Show

 ZFA:0000473 trunk musculature trunk musculature quality , abnormal
Show

 ZFA:0000610 vertical myoseptum vertical myoseptum malformed , abnormal
vertical myoseptum basement membrane malformed , abnormal
Show

 ZFA:0001056 myotome myotome myoseptum mislocalised , abnormal
myotome muscle cell retracted , abnormal
myotome skeletal muscle cell decreased amount , abnormal
myotome skeletal muscle cell degeneration , abnormal
myotome degenerate , abnormal
myotome refractivity , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
Show

 ZFA:0005145 muscle muscle dystrophic , abnormal
Show

 ZFA:0009115 skeletal muscle cell skeletal muscle cell sarcolemma broken , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell retracted , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000036279 lamc1 / Q1LVF0 / laminin, gamma 1 / P11047* / laminin subunit gamma 1*  / complex
 ENSDARG00000071863 itgb1a / integrin, beta 1a / ITGB1* / P05556* / P09055* / Integrin beta-1 * / integrin subunit beta 1*  / complex / reaction
 ENSDARG00000037917 itga3a / integrin, alpha 3a / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*  / complex / reaction
 ENSDARG00000012824 itga3b / integrin, alpha 3b / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*  / complex / reaction
 ENSDARG00000093572 lamc3 / laminin, gamma 3 / Q9R0B6* / Q9Y6N6* / laminin subunit gamma 3*  / complex






 

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