ENSMUSG00000052911


Mus musculus

Features
Gene ID: ENSMUSG00000052911
  
Biological name :Lamb2
  
Synonyms : Lamb2 / Laminin subunit beta-2 / Q61292
  
Possible biological names infered from orthology : P55268
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 108479736
Gene end: 108490530
  
Corresponding Affymetrix probe sets: 10588942 (MoGene1.0st)   1416513_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069087
Ensembl peptide - ENSMUSP00000142304
Ensembl peptide - ENSMUSP00000141757
Ensembl peptide - ENSMUSP00000141562
NCBI entrez gene - 16779     See in Manteia.
MGI - MGI:99916
RefSeq - XM_006511648
RefSeq - NM_008483
RefSeq Peptide - NP_032509
swissprot - A0A0A6YWY6
swissprot - A0A0A6YY71
swissprot - Q61292
swissprot - A0A0A6YWI2
Ensembl - ENSMUSG00000052911
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamb2ENSDARG00000002084Danio rerio
 LAMB2ENSGALG00000006802Gallus gallus
 LAMB2ENSG00000172037Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lamb1 / P02469 / Laminin subunit beta-1 / P07942*ENSMUSG0000000290051
Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*ENSMUSG0000001564726
Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*ENSMUSG0000002442123
Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*ENSMUSG0000002663923
Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*ENSMUSG0000001989920
Lama1 / laminin subunit alpha 1 / P25391*ENSMUSG0000003279620
Lamc1 / laminin subunit gamma 1 / P11047*ENSMUSG0000002647817
Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*ENSMUSG0000002684016
Ntn4 / Q9JI33 / Netrin-4 / Q9HB63*ENSMUSG0000002001913
Lamc2 / laminin subunit gamma 2 / Q13753*ENSMUSG0000002647911
Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*ENSMUSG0000001984610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR013015  Laminin IV type B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000904 cell morphogenesis involved in differentiation IGI
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007411 axon guidance IGI
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0007601 visual perception IGI
 biological_processGO:0014002 astrocyte development IGI
 biological_processGO:0014044 Schwann cell development IDA
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0048677 axon extension involved in regeneration IMP
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0060041 retina development in camera-type eye IGI
 biological_processGO:0072249 metanephric glomerular visceral epithelial cell development IMP
 biological_processGO:0072274 metanephric glomerular basement membrane development IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane ISO
 cellular_componentGO:0005605 basal lamina IDA
 cellular_componentGO:0005608 laminin-3 complex IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0043083 synaptic cleft IDA
 cellular_componentGO:0043256 laminin complex IDA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0005178 integrin binding IPI


Pathways (from Reactome)
Pathway description
Laminin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MET activates PTK2 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0001054 failure of presynaptic differentiation "inability of nerve terminals to find target and/or form terminal arbors for synaptic transmission" [J:61509]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0001055 failure of postsynaptic differentiation "inability of an effector cell to form a differentiated postsynaptic membrane in response to innervation" [J:61509]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: KitW-84J/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs,Lamc3tm1.1Wjbr/Lamc3tm1.1Wjbr
Genetic Background: B6.129-Lamc3tm1.1Wjbr Lamb2tm1Jrs

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: KitW-84J/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-84J/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-84J/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Lamb2npht/Lamb2npht
Genetic Background: involves: C57BL/6

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0004793 abnormal synaptic vesicle clustering "any functional anomaly in the process of accumulation of synaptic vesicles at the active zone of presynaptic membranes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Mnx1-cre)1Jrs/?
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-84J/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs,Lamc3tm1.1Wjbr/Lamc3tm1.1Wjbr
Genetic Background: B6.129-Lamc3tm1.1Wjbr Lamb2tm1Jrs

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs,Lamc3tm1.1Wjbr/Lamc3tm1.1Wjbr
Genetic Background: B6.129-Lamc3tm1.1Wjbr Lamb2tm1Jrs

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: KitW-84J/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005547 abnormal Muller cell morphology "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs,Lamc3tm1.1Wjbr/Lamc3tm1.1Wjbr
Genetic Background: B6.129-Lamc3tm1.1Wjbr Lamb2tm1Jrs

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lamb2npht/Lamb2npht
Genetic Background: involves: C57BL/6

 MP:0008106 decreased amacrine cell number "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs,Lamc3tm1.1Wjbr/Lamc3tm1.1Wjbr
Genetic Background: B6.129-Lamc3tm1.1Wjbr Lamb2tm1Jrs

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008139 fused podocyte foot processes "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0008582 short photoreceptor inner segment "decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamb2npht/Lamb2npht
Genetic Background: involves: C57BL/6

 MP:0009772 abnormal retinal development "anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs,Lamc3tm1.1Wjbr/Lamc3tm1.1Wjbr
Genetic Background: B6.129-Lamc3tm1.1Wjbr Lamb2tm1Jrs

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010235 abnormal retina inner limiting membrane morphology "any structural anomaly of the row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Lamb2npht/Lamb2npht
Genetic Background: involves: C57BL/6

 MP:0011856 abnormal glomerular filtration barrier function "anomaly in the function of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte); the barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman s space and prevents the loss of large and/or negatively charged proteins (e.g. serum albumin) from blood into urine" [MGI:anna]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019846 Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*  / complex
 ENSMUSG00000015647 Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*  / complex
 ENSMUSG00000026478 Lamc1 / laminin subunit gamma 1 / P11047*  / complex
 ENSMUSG00000026479 Lamc2 / laminin subunit gamma 2 / Q13753*  / complex
 ENSMUSG00000001507 Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*  / complex / reaction
 ENSMUSG00000026840 Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*  / complex
 ENSMUSG00000020758 Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*  / complex / reaction
 ENSMUSG00000032796 Lama1 / laminin subunit alpha 1 / P25391*  / complex
 ENSMUSG00000027111 Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*  / complex / reaction
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / complex
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction
 ENSMUSG00000019899 Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*  / complex






 

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