ENSDARG00000012824


Danio rerio

Features
Gene ID: ENSDARG00000012824
  
Biological name :itga3b
  
Synonyms : integrin, alpha 3b / itga3b
  
Possible biological names infered from orthology : Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / integrin subunit alpha 3 / ITGA3 / P26006 / Q62470
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 5587347
Gene end: 5663189
  
Corresponding Affymetrix probe sets: Dr.21839.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000096662
NCBI entrez gene - 100331874     See in Manteia.
RefSeq - NM_001190309
RefSeq Peptide - NP_001177238
swissprot - F1R2R3
ZFIN ID - ZDB-GENE-050411-55
Ensembl - ENSDARG00000012824
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ITGA3ENSGALG00000032702Gallus gallus
 ITGA3ENSG00000005884Homo sapiens
 Itga3ENSMUSG00000001507Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
itga3a / integrin, alpha 3a / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*ENSDARG0000003791748
itga6a / integrin, alpha 6a / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000004228234
itga6b / integrin, alpha 6b / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000006994634
itga6l / integrin, alpha 6, like / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000005601830
itga8 / integrin, alpha 8 / P53708* / A2ARA8* / integrin subunit alpha 8* / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain*ENSDARG0000007871726
itga5 / integrin, alpha 5 (fibronectin receptor, alpha polypeptide) / P08648* / P11688* / integrin subunit alpha 5* / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain*ENSDARG0000000635325
itgav / integrin, alpha V / P06756* / integrin subunit alpha V*ENSDARG0000000631424
itga2b / integrin, alpha 2b / P08514* / Q9QUM0* / integrin subunit alpha 2b*ENSDARG0000001868724
itga9 / integrin, alpha 9 / Q13797* / integrin subunit alpha 9*ENSDARG0000003243523
itga11a / integrin, alpha 11a / ITGA11* / Q9UKX5* / integrin subunit alpha 11*ENSDARG0000003608623
itga10 / integrin, alpha 10 / O75578* / integrin subunit alpha 10*ENSDARG0000000250722
itga11b / integrin, alpha 11b / ITGA11* / Q9UKX5* / integrin subunit alpha 11*ENSDARG0000000795022
itga4 / integrin alpha 4 / P13612* / integrin subunit alpha 4*ENSDARG0000010305622
itga1 / integrin, alpha 1 / P56199* / Q3V3R4* / integrin subunit alpha 1*ENSDARG0000007431621
itga2.2 / integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2 / ITGA2* / P17301* / Q62469* / Integrin alpha-2 * / integrin subunit alpha 2*ENSDARG0000006297420
si:dkey-32n7.4 / ITGAD* / ITGAM* / ITGAX* / Q13349* / P11215* / P20702* / Q9QXH4* / Q3V0T4* / integrin alpha M* / Integrin alpha-X * / Integrin alpha-D * / integrin subunit alpha X* / integ...ENSDARG0000000295619
zmp:0000001082 / ITGAL* / P20701* / P24063* / Integrin alpha-L * / integrin subunit alpha L*ENSDARG0000009889917
itgae.2 / integrin, alpha E, tandem duplicate 2 / ITGAE* / P38570* / Q60677* / integrin subunit alpha E* / integrin alpha E, epithelial-associated*ENSDARG0000005778714
itgam / integrin, alpha M (complement component 3 receptor 3 subunit) / ITGAD* / ITGAX* / P11215* / P20702* / Q13349* / Q3V0T4* / Q9QXH4* / integrin alpha M* / Integrin alpha-X * / Integrin...ENSDARG0000009658713
CU469503.1 / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000009934812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0033333 fin development IMP
 biological_processGO:0033334 fin morphogenesis IMP
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Basigin interactions
Integrin cell surface interactions
Laminin interactions
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000040 median fin fold median fin fold degenerate , abnormal
median fin fold rough , abnormal
median fin fold cell circular , abnormal
median fin fold malformed , abnormal
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 ZFA:0000108 fin fin degenerate , abnormal
fin necrotic , abnormal
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 ZFA:0000292 surface structure surface structure quality , abnormal
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 ZFA:0000368 integument integument cell circular , abnormal
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 ZFA:0001058 caudal fin caudal fin has fewer parts of type lepidotrichium , abnormal
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 ZFA:0001069 ventral fin fold ventral fin fold rough , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
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 ZFA:0001161 pectoral fin pectoral fin has fewer parts of type lepidotrichium , abnormal
pectoral fin degenerate , abnormal
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 ZFA:0001162 anal fin anal fin has fewer parts of type lepidotrichium , abnormal
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 ZFA:0001173 dorsal fin dorsal fin has fewer parts of type lepidotrichium , abnormal
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 ZFA:0001180 epidermal basal stratum epidermal basal stratum malformed , abnormal
epidermal basal stratum epithelial cell morphogenesis decreased process quality , abnormal
epidermal basal stratum ecto-epithelial cell oblong , abnormal
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 ZFA:0005597 median fin median fin broken , abnormal
median fin ruffled , abnormal
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 ZFA:0009091 melanocyte melanocyte irregular spatial pattern , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010785 thbs1b / thrombospondin 1b / THBS1* / P07996* / thrombospondin 1*  / complex / reaction
 ENSDARG00000036279 lamc1 / Q1LVF0 / laminin, gamma 1 / P11047* / laminin subunit gamma 1*  / complex / reaction
 ENSDARG00000071863 itgb1a / integrin, beta 1a / ITGB1* / P05556* / P09055* / Integrin beta-1 * / integrin subunit beta 1*  / complex
 ENSDARG00000002084 lamb2 / laminin, beta 2 (laminin S) / P55268* / Q61292* / laminin subunit beta 2*  / complex / reaction






 

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